Strategies for the synthesis of brevipolides

Strategies for the synthesis of brevipolides

In recent years fifteen 5,6-dihydro-α-pyrone derivatives, bearing either a distinctive cyclopropane or furan ring and named brevipolides A–O (1–15), have been isolated from the invasive plant Hyptis brevipes Poit. Their fascinating structural features, and the potent biological activities, including...

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Main Authors: Yudhi D. Kurniawan, A'liyatur Rosyidah
Format: Article
Language:English
Published: Beilstein-Institut 2021-09-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
brevipolides
5,6-dihydro-α-pyrone
furukawa-modified simmons–smith cyclopropanation
hyptis brevipes poit
ring-closing metathesis
Online Access:https://doi.org/10.3762/bjoc.17.157
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spelling doaj-80451481f5474e52a76cd992295a249b2021-10-05T13:40:35ZengBeilstein-InstitutBeilstein Journal of Organic Chemistry1860-53972021-09-011712399241610.3762/bjoc.17.1571860-5397-17-157Strategies for the synthesis of brevipolidesYudhi D. Kurniawan0A'liyatur Rosyidah1Research Center for Biomaterials, National Research and Innovation Agency, Cibinong, 16911, IndonesiaResearch Center for Biology, National Research and Innovation Agency, Cibinong, 16911, IndonesiaIn recent years fifteen 5,6-dihydro-α-pyrone derivatives, bearing either a distinctive cyclopropane or furan ring and named brevipolides A–O (1–15), have been isolated from the invasive plant Hyptis brevipes Poit. Their fascinating structural features, and the potent biological activities, including cytotoxicity against an array of human cancer cell lines and inhibition of the chemokine receptor CCR5, make them attractive synthetic targets. This review article highlights the recent synthetic methodologies and briefly summarizes their biological activities.https://doi.org/10.3762/bjoc.17.157brevipolides5,6-dihydro-α-pyronefurukawa-modified simmons–smith cyclopropanationhyptis brevipes poitring-closing metathesis
collection DOAJ
language English
format Article
sources DOAJ
author Yudhi D. Kurniawan
A'liyatur Rosyidah
spellingShingle Yudhi D. Kurniawan
A'liyatur Rosyidah
Strategies for the synthesis of brevipolides
Beilstein Journal of Organic Chemistry
brevipolides
5,6-dihydro-α-pyrone
furukawa-modified simmons–smith cyclopropanation
hyptis brevipes poit
ring-closing metathesis
author_facet Yudhi D. Kurniawan
A'liyatur Rosyidah
author_sort Yudhi D. Kurniawan
title Strategies for the synthesis of brevipolides
title_short Strategies for the synthesis of brevipolides
title_full Strategies for the synthesis of brevipolides
title_fullStr Strategies for the synthesis of brevipolides
title_full_unstemmed Strategies for the synthesis of brevipolides
title_sort strategies for the synthesis of brevipolides
publisher Beilstein-Institut
series Beilstein Journal of Organic Chemistry
issn 1860-5397
publishDate 2021-09-01
description In recent years fifteen 5,6-dihydro-α-pyrone derivatives, bearing either a distinctive cyclopropane or furan ring and named brevipolides A–O (1–15), have been isolated from the invasive plant Hyptis brevipes Poit. Their fascinating structural features, and the potent biological activities, including cytotoxicity against an array of human cancer cell lines and inhibition of the chemokine receptor CCR5, make them attractive synthetic targets. This review article highlights the recent synthetic methodologies and briefly summarizes their biological activities.
topic brevipolides
5,6-dihydro-α-pyrone
furukawa-modified simmons–smith cyclopropanation
hyptis brevipes poit
ring-closing metathesis
url https://doi.org/10.3762/bjoc.17.157
work_keys_str_mv AT yudhidkurniawan strategiesforthesynthesisofbrevipolides
AT aliyaturrosyidah strategiesforthesynthesisofbrevipolides
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