FOLATE CYCLE GENE POLYMORPHISM AND ENDOGENOUS PEPTIDES IN CHILDREN WITH COW’S MILK PROTEIN ALLERGY

FOLATE CYCLE GENE POLYMORPHISM AND ENDOGENOUS PEPTIDES IN CHILDREN WITH COW’S MILK PROTEIN ALLERGY

Folate cycle gene polymorphisms and the levels of endogenous antimicrobial peptides and proteins in the blood and coprofiltrates were studied in 45 children aged 3 to 12 months with cow’s milk protein allergy. The polymorphic variants of the MTHFR, MTRR, and MTR genes were shown to be considered as...

Full description

Bibliographic Details
Main Authors: T. A. Shumatova, N. G. Prikhodchenko, E. S. Zernova, I. V. Efremova, S. N. Shishatskay, A. N. Ni, L. A. Grigoryan, E. Yu. Katenkova
Format: Article
Language:Russian
Published: Ltd. “The National Academy of Pediatric Science and Innovation” 2017-01-01
Series:Rossijskij Vestnik Perinatologii i Pediatrii
Subjects:
children
cow’s milk protein allergy
fatty acid-binding proteins
membrane permeability-increasing protein
folate cycle genes
eosinophil cationic protein
intestinal fatty acid-binding protein
liver fatty acid-binding protein
bactericidal/permeability-increasing protein
Online Access:https://www.ped-perinatology.ru/jour/article/view/426
id doaj-80458df05e6041a6a988b66eff9c1aba
record_format Article
spelling doaj-80458df05e6041a6a988b66eff9c1aba2021-07-28T16:27:46ZrusLtd. “The National Academy of Pediatric Science and Innovation”Rossijskij Vestnik Perinatologii i Pediatrii1027-40652500-22282017-01-0161611311810.21508/1027-4065-2016-61-6-113-118403FOLATE CYCLE GENE POLYMORPHISM AND ENDOGENOUS PEPTIDES IN CHILDREN WITH COW’S MILK PROTEIN ALLERGYT. A. Shumatova0N. G. Prikhodchenko1E. S. Zernova2I. V. Efremova3S. N. Shishatskay4A. N. Ni5L. A. Grigoryan6E. Yu. Katenkova7Pacific State Medical University, Vladivostok, RussiaPacific State Medical University, Vladivostok, RussiaPacific State Medical University, Vladivostok, RussiaPacific State Medical University, Vladivostok, RussiaPacific State Medical University, Vladivostok, RussiaPacific State Medical University, Vladivostok, RussiaPacific State Medical University, Vladivostok, RussiaPacific State Medical University, Vladivostok, RussiaFolate cycle gene polymorphisms and the levels of endogenous antimicrobial peptides and proteins in the blood and coprofiltrates were studied in 45 children aged 3 to 12 months with cow’s milk protein allergy. The polymorphic variants of the MTHFR, MTRR, and MTR genes were shown to be considered as a risk factor for the development of allergy. There was a significant increase in the levels of zonulin, β-defensin 2, transthyretin, and eosinophil cationic protein in the coprofiltrates and in those of eotaxin, fatty acidbinding proteins, and membrane permeability-increasing protein in the serum (p<0.05). The finding can improve the diagnosis of the disease for a predictive purpose for the evaluation of the efficiency of performed therapy.https://www.ped-perinatology.ru/jour/article/view/426childrencow’s milk protein allergyfatty acid-binding proteinsmembrane permeability-increasing proteinfolate cycle geneseosinophil cationic proteinintestinal fatty acid-binding proteinliver fatty acid-binding proteinbactericidal/permeability-increasing protein
collection DOAJ
language Russian
format Article
sources DOAJ
author T. A. Shumatova
N. G. Prikhodchenko
E. S. Zernova
I. V. Efremova
S. N. Shishatskay
A. N. Ni
L. A. Grigoryan
E. Yu. Katenkova
spellingShingle T. A. Shumatova
N. G. Prikhodchenko
E. S. Zernova
I. V. Efremova
S. N. Shishatskay
A. N. Ni
L. A. Grigoryan
E. Yu. Katenkova
FOLATE CYCLE GENE POLYMORPHISM AND ENDOGENOUS PEPTIDES IN CHILDREN WITH COW’S MILK PROTEIN ALLERGY
Rossijskij Vestnik Perinatologii i Pediatrii
children
cow’s milk protein allergy
fatty acid-binding proteins
membrane permeability-increasing protein
folate cycle genes
eosinophil cationic protein
intestinal fatty acid-binding protein
liver fatty acid-binding protein
bactericidal/permeability-increasing protein
author_facet T. A. Shumatova
N. G. Prikhodchenko
E. S. Zernova
I. V. Efremova
S. N. Shishatskay
A. N. Ni
L. A. Grigoryan
E. Yu. Katenkova
author_sort T. A. Shumatova
title FOLATE CYCLE GENE POLYMORPHISM AND ENDOGENOUS PEPTIDES IN CHILDREN WITH COW’S MILK PROTEIN ALLERGY
title_short FOLATE CYCLE GENE POLYMORPHISM AND ENDOGENOUS PEPTIDES IN CHILDREN WITH COW’S MILK PROTEIN ALLERGY
title_full FOLATE CYCLE GENE POLYMORPHISM AND ENDOGENOUS PEPTIDES IN CHILDREN WITH COW’S MILK PROTEIN ALLERGY
title_fullStr FOLATE CYCLE GENE POLYMORPHISM AND ENDOGENOUS PEPTIDES IN CHILDREN WITH COW’S MILK PROTEIN ALLERGY
title_full_unstemmed FOLATE CYCLE GENE POLYMORPHISM AND ENDOGENOUS PEPTIDES IN CHILDREN WITH COW’S MILK PROTEIN ALLERGY
title_sort folate cycle gene polymorphism and endogenous peptides in children with cow’s milk protein allergy
publisher Ltd. “The National Academy of Pediatric Science and Innovation”
series Rossijskij Vestnik Perinatologii i Pediatrii
issn 1027-4065
2500-2228
publishDate 2017-01-01
description Folate cycle gene polymorphisms and the levels of endogenous antimicrobial peptides and proteins in the blood and coprofiltrates were studied in 45 children aged 3 to 12 months with cow’s milk protein allergy. The polymorphic variants of the MTHFR, MTRR, and MTR genes were shown to be considered as a risk factor for the development of allergy. There was a significant increase in the levels of zonulin, β-defensin 2, transthyretin, and eosinophil cationic protein in the coprofiltrates and in those of eotaxin, fatty acidbinding proteins, and membrane permeability-increasing protein in the serum (p<0.05). The finding can improve the diagnosis of the disease for a predictive purpose for the evaluation of the efficiency of performed therapy.
topic children
cow’s milk protein allergy
fatty acid-binding proteins
membrane permeability-increasing protein
folate cycle genes
eosinophil cationic protein
intestinal fatty acid-binding protein
liver fatty acid-binding protein
bactericidal/permeability-increasing protein
url https://www.ped-perinatology.ru/jour/article/view/426
work_keys_str_mv AT tashumatova folatecyclegenepolymorphismandendogenouspeptidesinchildrenwithcowsmilkproteinallergy
AT ngprikhodchenko folatecyclegenepolymorphismandendogenouspeptidesinchildrenwithcowsmilkproteinallergy
AT eszernova folatecyclegenepolymorphismandendogenouspeptidesinchildrenwithcowsmilkproteinallergy
AT ivefremova folatecyclegenepolymorphismandendogenouspeptidesinchildrenwithcowsmilkproteinallergy
AT snshishatskay folatecyclegenepolymorphismandendogenouspeptidesinchildrenwithcowsmilkproteinallergy
AT anni folatecyclegenepolymorphismandendogenouspeptidesinchildrenwithcowsmilkproteinallergy
AT lagrigoryan folatecyclegenepolymorphismandendogenouspeptidesinchildrenwithcowsmilkproteinallergy
AT eyukatenkova folatecyclegenepolymorphismandendogenouspeptidesinchildrenwithcowsmilkproteinallergy
_version_ 1721266308459266048

Similar Items