Effect of reserved line’s anti-tuberculosis medicines to antiinflammatory cytokine production for patients with pulmonary tuberculosis

• Main Authors: T. Ye. Kononova, O. I. Urazova, V. A. Serebryakova, V. V. Novitsky, O. A. Vasiliyeva, I. O. Naslednikova, O. V. Voronkova, R. R. Khasanova, A. Ye. Kolosova
• Format: Article
• Language: English
• Published: Siberian State Medical University (Tomsk) 2010-10-01
• Series: Bûlleten' Sibirskoj Mediciny
• Subjects: pulmonary tuberculosis; anti-tuberculosis medicines of reserved line; cytokine production
• Online Access: https://bulletin.tomsk.ru/jour/article/view/1661

The results of research show the impact of ofloxacin, para-aminosalicylic acid (PASA) and capreomycin in conjunction with the BCG vaccine strain to the cytokine-production ability of mononuclear peripheral blood leukocytes for patients with infiltrative pulmonary tuberculosis prior to specific antituberculosis therapy. The results show that ofloxacin has inducing effect on the secretion of interleukin (IL) 4 and transforming growth factor (TGF) β; PASA and capreomycin have such effect for the products of IL10 and TGFβ. This influence has a negative effect during the active development of the pathological process and during specific treatment.