Oxygen Is an Ambivalent Factor for the Differentiation of Human Pluripotent Stem Cells in Cardiac 2D Monolayer and 3D Cardiac Spheroids

Oxygen Is an Ambivalent Factor for the Differentiation of Human Pluripotent Stem Cells in Cardiac 2D Monolayer and 3D Cardiac Spheroids

Numerous protocols of cardiac differentiation have been established by essentially focusing on specific growth factors on human pluripotent stem cell (hPSC) differentiation efficiency. However, the optimal environmental factors to obtain cardiac myocytes in network are still unclear. The mesoderm ge...

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Bibliographic Details
Main Authors: Monia Souidi, Yvonne Sleiman, Ivana Acimovic, Jan Pribyl, Azzouz Charrabi, Volker Baecker, Valerie Scheuermann, Martin Pesl, Sarka Jelinkova, Petr Skladal, Petr Dvorak, Alain Lacampagne, Vladimir Rotrekl, Albano C. Meli
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:International Journal of Molecular Sciences
Subjects:
hPSC-derived cardiomyocytes
cardiac spheroids
embryoid bodies
2D-monolayer
oxygen exposure
intracellular calcium handling
Online Access:https://www.mdpi.com/1422-0067/22/2/662

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