Prokineticin 2 via Calcium-Sensing Receptor Activated NLRP3 Inflammasome Pathway in the Testicular Macrophages of Uropathogenic Escherichia coli-Induced Orchitis

Prokineticin 2 via Calcium-Sensing Receptor Activated NLRP3 Inflammasome Pathway in the Testicular Macrophages of Uropathogenic Escherichia coli-Induced Orchitis

Reproductive tract infections contribute to the development of testicular inflammatory lesions, leading to male infertility. Previous research shows that the activation of the NLRP3 inflammasome in orchitis promotes the secretion and maturation of IL-1β and, thus, decreases male fertility. The calci...

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Bibliographic Details
Main Authors: Yufang Su, Yuan Zhang, Zhiyong Hu, Liting He, Wei Wang, Jia Xu, Zunpan Fan, Chunyan Liu, Huiping Zhang, Kai Zhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Immunology
Subjects:
calcium-sensing receptor
testicular macrophages
inflammasome
orchitis
prokineticin 2
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.570872/full

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