In vitro activity of imipenem/relebactam against Enterobacteriaceae and Pseudomonas aeruginosa isolated from intraabdominal and urinary tract infection samples: SMART Surveillance United States 2015–2017
Objectives: Antimicrobial resistance, including multidrug-resistance (MDR), is increasing, especially among Gram-negative bacilli. New agents are needed to treat infections caused by these pathogens. This report assessed the activity of imipenem/relebactam against Gram-negative bacilli from intraabd...
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doaj-8064bc699cc54176969e197c3f8f5dfa2021-05-20T07:48:50ZengElsevierJournal of Global Antimicrobial Resistance2213-71652020-06-0121223228In vitro activity of imipenem/relebactam against Enterobacteriaceae and Pseudomonas aeruginosa isolated from intraabdominal and urinary tract infection samples: SMART Surveillance United States 2015–2017James A. Karlowsky0Sibylle H. Lob1Krystyna M. Kazmierczak2Katherine Young3Mary R. Motyl4Daniel F. Sahm5International Health Management Associates, Inc., Schaumburg, IL, USA; Department of Medical Microbiology and Infectious Diseases, Max Rady College of Medicine, University of Manitoba, Winnipeg, CanadaInternational Health Management Associates, Inc., Schaumburg, IL, USA; Corresponding author at: International Health Management Associates, Inc., 2122 Palmer Drive, Schaumburg, IL, 60173, USA.International Health Management Associates, Inc., Schaumburg, IL, USAMerck & Co., Inc., Kenilworth, NJ, USAMerck & Co., Inc., Kenilworth, NJ, USAInternational Health Management Associates, Inc., Schaumburg, IL, USAObjectives: Antimicrobial resistance, including multidrug-resistance (MDR), is increasing, especially among Gram-negative bacilli. New agents are needed to treat infections caused by these pathogens. This report assessed the activity of imipenem/relebactam against Gram-negative bacilli from intraabdominal infections (IAIs) and urinary tract infections (UTIs) submitted to the SMART (Study for Monitoring Antimicrobial Resistance Trends) global surveillance programme in the United States from 2015 to 2017. Methods: Broth microdilution MICs for imipenem/relebactam and comparators were determined by a central laboratory against isolates of non-Proteeae Enterobacteriaceae (NPE) and Pseudomonas aeruginosa (P. aeruginosa). Imipenem/relebactam MICs were interpreted using United States Food and Drug Administration (FDA) breakpoints. Results: 99.5% of NPE isolates collected from patients with IAIs (n = 3633) and UTIs (n = 3038) were susceptible to imipenem/relebactam, as were 77.9% of imipenem-nonsusceptible, 96.3% of Klebsiella pneumoniae carbapenemase (KPC)-positive, and 98.7% of MDR isolates from IAIs and UTIs combined. A total of 96.7% of IAI isolates (n = 486) and 96.4% of UTI isolates (n = 360) of P. aeruginosa were susceptible to imipenem/relebactam, as were 85.0% of imipenem-nonsusceptible and 87.3% of MDR isolates from IAIs and UTIs combined. Percent susceptibility to imipenem/relebactam for cefepime-, ceftazidime-, and piperacillin-tazobactam-nonsusceptible isolates was 98.3–98.8% for NPE and 87.3–90.0% for P. aeruginosa. Conclusions: Imipenem/relebactam demonstrated potent in vitro activity against NPE and P. aeruginosa isolates from IAIs and UTIs, including against resistant subsets, and will provide important coverage for IAIs and UTIs caused by β-lactam-resistant, MDR, and KPC-positive Gram-negative bacilli.http://www.sciencedirect.com/science/article/pii/S2213716519302905Imipenem/relebactamGram-negative bacilliUnited StatesStudy for Monitoring Antimicrobial Resistance Trends (SMART)Intraabdominal infectionUrinary tract infection |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
James A. Karlowsky Sibylle H. Lob Krystyna M. Kazmierczak Katherine Young Mary R. Motyl Daniel F. Sahm |
spellingShingle |
James A. Karlowsky Sibylle H. Lob Krystyna M. Kazmierczak Katherine Young Mary R. Motyl Daniel F. Sahm In vitro activity of imipenem/relebactam against Enterobacteriaceae and Pseudomonas aeruginosa isolated from intraabdominal and urinary tract infection samples: SMART Surveillance United States 2015–2017 Journal of Global Antimicrobial Resistance Imipenem/relebactam Gram-negative bacilli United States Study for Monitoring Antimicrobial Resistance Trends (SMART) Intraabdominal infection Urinary tract infection |
author_facet |
James A. Karlowsky Sibylle H. Lob Krystyna M. Kazmierczak Katherine Young Mary R. Motyl Daniel F. Sahm |
author_sort |
James A. Karlowsky |
title |
In vitro activity of imipenem/relebactam against Enterobacteriaceae and Pseudomonas aeruginosa isolated from intraabdominal and urinary tract infection samples: SMART Surveillance United States 2015–2017 |
title_short |
In vitro activity of imipenem/relebactam against Enterobacteriaceae and Pseudomonas aeruginosa isolated from intraabdominal and urinary tract infection samples: SMART Surveillance United States 2015–2017 |
title_full |
In vitro activity of imipenem/relebactam against Enterobacteriaceae and Pseudomonas aeruginosa isolated from intraabdominal and urinary tract infection samples: SMART Surveillance United States 2015–2017 |
title_fullStr |
In vitro activity of imipenem/relebactam against Enterobacteriaceae and Pseudomonas aeruginosa isolated from intraabdominal and urinary tract infection samples: SMART Surveillance United States 2015–2017 |
title_full_unstemmed |
In vitro activity of imipenem/relebactam against Enterobacteriaceae and Pseudomonas aeruginosa isolated from intraabdominal and urinary tract infection samples: SMART Surveillance United States 2015–2017 |
title_sort |
in vitro activity of imipenem/relebactam against enterobacteriaceae and pseudomonas aeruginosa isolated from intraabdominal and urinary tract infection samples: smart surveillance united states 2015–2017 |
publisher |
Elsevier |
series |
Journal of Global Antimicrobial Resistance |
issn |
2213-7165 |
publishDate |
2020-06-01 |
description |
Objectives: Antimicrobial resistance, including multidrug-resistance (MDR), is increasing, especially among Gram-negative bacilli. New agents are needed to treat infections caused by these pathogens. This report assessed the activity of imipenem/relebactam against Gram-negative bacilli from intraabdominal infections (IAIs) and urinary tract infections (UTIs) submitted to the SMART (Study for Monitoring Antimicrobial Resistance Trends) global surveillance programme in the United States from 2015 to 2017. Methods: Broth microdilution MICs for imipenem/relebactam and comparators were determined by a central laboratory against isolates of non-Proteeae Enterobacteriaceae (NPE) and Pseudomonas aeruginosa (P. aeruginosa). Imipenem/relebactam MICs were interpreted using United States Food and Drug Administration (FDA) breakpoints. Results: 99.5% of NPE isolates collected from patients with IAIs (n = 3633) and UTIs (n = 3038) were susceptible to imipenem/relebactam, as were 77.9% of imipenem-nonsusceptible, 96.3% of Klebsiella pneumoniae carbapenemase (KPC)-positive, and 98.7% of MDR isolates from IAIs and UTIs combined. A total of 96.7% of IAI isolates (n = 486) and 96.4% of UTI isolates (n = 360) of P. aeruginosa were susceptible to imipenem/relebactam, as were 85.0% of imipenem-nonsusceptible and 87.3% of MDR isolates from IAIs and UTIs combined. Percent susceptibility to imipenem/relebactam for cefepime-, ceftazidime-, and piperacillin-tazobactam-nonsusceptible isolates was 98.3–98.8% for NPE and 87.3–90.0% for P. aeruginosa. Conclusions: Imipenem/relebactam demonstrated potent in vitro activity against NPE and P. aeruginosa isolates from IAIs and UTIs, including against resistant subsets, and will provide important coverage for IAIs and UTIs caused by β-lactam-resistant, MDR, and KPC-positive Gram-negative bacilli. |
topic |
Imipenem/relebactam Gram-negative bacilli United States Study for Monitoring Antimicrobial Resistance Trends (SMART) Intraabdominal infection Urinary tract infection |
url |
http://www.sciencedirect.com/science/article/pii/S2213716519302905 |
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