Effect of Tulathromycin on colonization resistance, antimicrobial resistance and virulence of human gut microbiota in Chemostats
To evaluate microbiological safety of tulathromycin on human intestinal bacteria, tulathromycin (0, 0.1, 1,10 and 100μg/mL) was added into Chemostats. Before and after drug exposure, we monitored 1) population, SCFA products, antimicrobial resistance and colonization resistance of gut microbiota, an...
Main Authors: | , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2016-04-01
|
Series: | Frontiers in Microbiology |
Subjects: | |
Online Access: | http://journal.frontiersin.org/Journal/10.3389/fmicb.2016.00477/full |
id |
doaj-806672ea68cf4b7b92cf50075c294c55 |
---|---|
record_format |
Article |
spelling |
doaj-806672ea68cf4b7b92cf50075c294c552020-11-24T22:29:49ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2016-04-01710.3389/fmicb.2016.00477184950Effect of Tulathromycin on colonization resistance, antimicrobial resistance and virulence of human gut microbiota in ChemostatsHaihong eHao0Shengxi eZhou1Guyue eCheng2Menghong eDai3zhenli eliu4Xu eWang5Yulian eWang6Zonghui eYuan7Huazhong Agricultural UniversityHuazhong Agricultural UniversityHuazhong Agricultural UniversityHuazhong Agricultural UniversityHuazhong Agricultural UniversityHuazhong Agricultural UniversityHuazhong Agricultural UniversityHuazhong Agricultural UniversityTo evaluate microbiological safety of tulathromycin on human intestinal bacteria, tulathromycin (0, 0.1, 1,10 and 100μg/mL) was added into Chemostats. Before and after drug exposure, we monitored 1) population, SCFA products, antimicrobial resistance and colonization resistance of gut microbiota, and 2) the antimicrobial resistance genes, transferability, virulent genes, pathogenicity of Enterococus faecalis. Results showed that low level of tulathromycin did not exhibit microbiological hazard on resistance selection and colonization resistance. However, high level of tulathromycin (10 and 100 µg/mL) may disturb colonization resistance of human gut microbiota and select antimicrobial resistant E. faecalis. Most of the selected resistant E. faecalis carried resistant gene of ermB, transferable element of Tn1545 and three virulence genes (esp, cylA and ace). One of them (E. faecalis 143) was confirmed to have higher horizontal transfer risk and higher pathogenicity. The calculated no observable adverse effect concentration (NOAEC) and microbiological acceptable daily intake (mADI) in our study was 1μg/mL and 14.66µg/kg.bw/day, respectively.http://journal.frontiersin.org/Journal/10.3389/fmicb.2016.00477/fullantimicrobial resistanceGut Microbiotachemostatcolonization resistancetulathromycin |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Haihong eHao Shengxi eZhou Guyue eCheng Menghong eDai zhenli eliu Xu eWang Yulian eWang Zonghui eYuan |
spellingShingle |
Haihong eHao Shengxi eZhou Guyue eCheng Menghong eDai zhenli eliu Xu eWang Yulian eWang Zonghui eYuan Effect of Tulathromycin on colonization resistance, antimicrobial resistance and virulence of human gut microbiota in Chemostats Frontiers in Microbiology antimicrobial resistance Gut Microbiota chemostat colonization resistance tulathromycin |
author_facet |
Haihong eHao Shengxi eZhou Guyue eCheng Menghong eDai zhenli eliu Xu eWang Yulian eWang Zonghui eYuan |
author_sort |
Haihong eHao |
title |
Effect of Tulathromycin on colonization resistance, antimicrobial resistance and virulence of human gut microbiota in Chemostats |
title_short |
Effect of Tulathromycin on colonization resistance, antimicrobial resistance and virulence of human gut microbiota in Chemostats |
title_full |
Effect of Tulathromycin on colonization resistance, antimicrobial resistance and virulence of human gut microbiota in Chemostats |
title_fullStr |
Effect of Tulathromycin on colonization resistance, antimicrobial resistance and virulence of human gut microbiota in Chemostats |
title_full_unstemmed |
Effect of Tulathromycin on colonization resistance, antimicrobial resistance and virulence of human gut microbiota in Chemostats |
title_sort |
effect of tulathromycin on colonization resistance, antimicrobial resistance and virulence of human gut microbiota in chemostats |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Microbiology |
issn |
1664-302X |
publishDate |
2016-04-01 |
description |
To evaluate microbiological safety of tulathromycin on human intestinal bacteria, tulathromycin (0, 0.1, 1,10 and 100μg/mL) was added into Chemostats. Before and after drug exposure, we monitored 1) population, SCFA products, antimicrobial resistance and colonization resistance of gut microbiota, and 2) the antimicrobial resistance genes, transferability, virulent genes, pathogenicity of Enterococus faecalis. Results showed that low level of tulathromycin did not exhibit microbiological hazard on resistance selection and colonization resistance. However, high level of tulathromycin (10 and 100 µg/mL) may disturb colonization resistance of human gut microbiota and select antimicrobial resistant E. faecalis. Most of the selected resistant E. faecalis carried resistant gene of ermB, transferable element of Tn1545 and three virulence genes (esp, cylA and ace). One of them (E. faecalis 143) was confirmed to have higher horizontal transfer risk and higher pathogenicity. The calculated no observable adverse effect concentration (NOAEC) and microbiological acceptable daily intake (mADI) in our study was 1μg/mL and 14.66µg/kg.bw/day, respectively. |
topic |
antimicrobial resistance Gut Microbiota chemostat colonization resistance tulathromycin |
url |
http://journal.frontiersin.org/Journal/10.3389/fmicb.2016.00477/full |
work_keys_str_mv |
AT haihongehao effectoftulathromycinoncolonizationresistanceantimicrobialresistanceandvirulenceofhumangutmicrobiotainchemostats AT shengxiezhou effectoftulathromycinoncolonizationresistanceantimicrobialresistanceandvirulenceofhumangutmicrobiotainchemostats AT guyueecheng effectoftulathromycinoncolonizationresistanceantimicrobialresistanceandvirulenceofhumangutmicrobiotainchemostats AT menghongedai effectoftulathromycinoncolonizationresistanceantimicrobialresistanceandvirulenceofhumangutmicrobiotainchemostats AT zhenlieliu effectoftulathromycinoncolonizationresistanceantimicrobialresistanceandvirulenceofhumangutmicrobiotainchemostats AT xuewang effectoftulathromycinoncolonizationresistanceantimicrobialresistanceandvirulenceofhumangutmicrobiotainchemostats AT yulianewang effectoftulathromycinoncolonizationresistanceantimicrobialresistanceandvirulenceofhumangutmicrobiotainchemostats AT zonghuieyuan effectoftulathromycinoncolonizationresistanceantimicrobialresistanceandvirulenceofhumangutmicrobiotainchemostats |
_version_ |
1725743016042299392 |