Photosensitizer-Functionalized Nanocomposites for Light-Activated Cancer Theranostics
Photosensitizers (PSs) have received significant attention recently in cancer treatment due to its theranostic capability for imaging and phototherapy. These PSs are highly responsive to light source of a suitable wavelength for image-guided cancer therapy from generated singlet oxygen and/or therma...
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doaj-80774f19fa9e43fea701704a0f4ad24b2021-07-15T15:36:14ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-06-01226658665810.3390/ijms22136658Photosensitizer-Functionalized Nanocomposites for Light-Activated Cancer TheranosticsBanendu Sunder Dash0Suprava Das1Jyh-Ping Chen2Department of Chemical and Materials Engineering, Chang Gung University, Kwei-San, Taoyuan 33302, TaiwanDepartment of Chemical and Materials Engineering, Chang Gung University, Kwei-San, Taoyuan 33302, TaiwanDepartment of Chemical and Materials Engineering, Chang Gung University, Kwei-San, Taoyuan 33302, TaiwanPhotosensitizers (PSs) have received significant attention recently in cancer treatment due to its theranostic capability for imaging and phototherapy. These PSs are highly responsive to light source of a suitable wavelength for image-guided cancer therapy from generated singlet oxygen and/or thermal heat. Various organic dye PSs show tremendous attenuation of tumor cells during cancer treatment. Among them, porphyrin and chlorophyll-based ultraviolet-visible (UV-Vis) dyes are employed for photodynamic therapy (PDT) by reactive oxygen species (ROS) and free radicals generated with 400–700 nm laser lights, which have poor tissue penetration depth. To enhance the efficacy of PDT, other light sources such as red light laser and X-ray have been suggested; nonetheless, it is still a challenging task to improve the light penetration depth for deep tumor treatment. To overcome this deficiency, near infrared (NIR) (700–900 nm) PSs, indocyanine green (ICG), and its derivatives like IR780, IR806 and IR820, have been introduced for imaging and phototherapy. These NIR PSs have been used in various cancer treatment modality by combining photothermal therapy (PTT) and/or PDT with chemotherapy or immunotherapy. In this review, we will focus on the use of different PSs showing photothermal/photodynamic response to UV-Vis or NIR-Vis light. The emphasis is a comprehensive review of recent smart design of PS-loaded nanocomposites for targeted delivery of PSs in light-activated combination cancer therapy.https://www.mdpi.com/1422-0067/22/13/6658photosensitizercancer therapynanocompositephotodynamic therapyphotothermal therapy |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Banendu Sunder Dash Suprava Das Jyh-Ping Chen |
spellingShingle |
Banendu Sunder Dash Suprava Das Jyh-Ping Chen Photosensitizer-Functionalized Nanocomposites for Light-Activated Cancer Theranostics International Journal of Molecular Sciences photosensitizer cancer therapy nanocomposite photodynamic therapy photothermal therapy |
author_facet |
Banendu Sunder Dash Suprava Das Jyh-Ping Chen |
author_sort |
Banendu Sunder Dash |
title |
Photosensitizer-Functionalized Nanocomposites for Light-Activated Cancer Theranostics |
title_short |
Photosensitizer-Functionalized Nanocomposites for Light-Activated Cancer Theranostics |
title_full |
Photosensitizer-Functionalized Nanocomposites for Light-Activated Cancer Theranostics |
title_fullStr |
Photosensitizer-Functionalized Nanocomposites for Light-Activated Cancer Theranostics |
title_full_unstemmed |
Photosensitizer-Functionalized Nanocomposites for Light-Activated Cancer Theranostics |
title_sort |
photosensitizer-functionalized nanocomposites for light-activated cancer theranostics |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1661-6596 1422-0067 |
publishDate |
2021-06-01 |
description |
Photosensitizers (PSs) have received significant attention recently in cancer treatment due to its theranostic capability for imaging and phototherapy. These PSs are highly responsive to light source of a suitable wavelength for image-guided cancer therapy from generated singlet oxygen and/or thermal heat. Various organic dye PSs show tremendous attenuation of tumor cells during cancer treatment. Among them, porphyrin and chlorophyll-based ultraviolet-visible (UV-Vis) dyes are employed for photodynamic therapy (PDT) by reactive oxygen species (ROS) and free radicals generated with 400–700 nm laser lights, which have poor tissue penetration depth. To enhance the efficacy of PDT, other light sources such as red light laser and X-ray have been suggested; nonetheless, it is still a challenging task to improve the light penetration depth for deep tumor treatment. To overcome this deficiency, near infrared (NIR) (700–900 nm) PSs, indocyanine green (ICG), and its derivatives like IR780, IR806 and IR820, have been introduced for imaging and phototherapy. These NIR PSs have been used in various cancer treatment modality by combining photothermal therapy (PTT) and/or PDT with chemotherapy or immunotherapy. In this review, we will focus on the use of different PSs showing photothermal/photodynamic response to UV-Vis or NIR-Vis light. The emphasis is a comprehensive review of recent smart design of PS-loaded nanocomposites for targeted delivery of PSs in light-activated combination cancer therapy. |
topic |
photosensitizer cancer therapy nanocomposite photodynamic therapy photothermal therapy |
url |
https://www.mdpi.com/1422-0067/22/13/6658 |
work_keys_str_mv |
AT banendusunderdash photosensitizerfunctionalizednanocompositesforlightactivatedcancertheranostics AT supravadas photosensitizerfunctionalizednanocompositesforlightactivatedcancertheranostics AT jyhpingchen photosensitizerfunctionalizednanocompositesforlightactivatedcancertheranostics |
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1721299458126249984 |