Active Surveillance of Candidemia, Australia
Population-based surveillance for candidemia in Australia from 2001 to 2004 identified 1,095 cases. Annual overall and hospital-specific incidences were 1.81/100,000 and 0.21/1,000 separations (completed admissions), respectively. Predisposing factors included malignancy (32.1%), indwelling vascular...
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2006-10-01
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doaj-8082186b781e4fd39614e2fdeea42bce2020-11-25T01:11:14ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592006-10-0112101508151610.3201/eid1210.060389Active Surveillance of Candidemia, AustraliaSharon ChenMonica SlavinQuoc NguyenDeborah MarriottE. Geoffrey PlayfordDavid EllisTania C. SorrellPopulation-based surveillance for candidemia in Australia from 2001 to 2004 identified 1,095 cases. Annual overall and hospital-specific incidences were 1.81/100,000 and 0.21/1,000 separations (completed admissions), respectively. Predisposing factors included malignancy (32.1%), indwelling vascular catheters (72.6%), use of antimicrobial agents (77%), and surgery (37.1%). Of 919 episodes, 81.5% were inpatient healthcare associated (IHCA), 11.6% were outpatient healthcare associated (OHCA), and 6.9% were community acquired (CA). Concomitant illnesses and risk factors were similar in IHCA and OHCA candidemia. IHCA candidemia was associated with sepsis at diagnosis (p<0.001), death <30 days after infection (p<0.001), and prolonged hospital admission (p<0.001). Non–Candida albicans species (52.7%) caused 60.5% of cases acquired outside hospitals and 49.9% of IHCA candidemia (p = 0.02). The 30-day death rate was 27.7% in those >65 years of age. Adult critical care stay, sepsis syndrome, and corticosteroid therapy were associated with the greatest risk for death. Systematic epidemiologic studies that use standardized definitions for IHCA, OHCA, and CA candidemia are indicated.https://wwwnc.cdc.gov/eid/article/12/10/06-0389_articlePopulation-basedcandidemiasurveillanceepidemiologyAustraliahealthcare-associated |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sharon Chen Monica Slavin Quoc Nguyen Deborah Marriott E. Geoffrey Playford David Ellis Tania C. Sorrell |
spellingShingle |
Sharon Chen Monica Slavin Quoc Nguyen Deborah Marriott E. Geoffrey Playford David Ellis Tania C. Sorrell Active Surveillance of Candidemia, Australia Emerging Infectious Diseases Population-based candidemia surveillance epidemiology Australia healthcare-associated |
author_facet |
Sharon Chen Monica Slavin Quoc Nguyen Deborah Marriott E. Geoffrey Playford David Ellis Tania C. Sorrell |
author_sort |
Sharon Chen |
title |
Active Surveillance of Candidemia, Australia |
title_short |
Active Surveillance of Candidemia, Australia |
title_full |
Active Surveillance of Candidemia, Australia |
title_fullStr |
Active Surveillance of Candidemia, Australia |
title_full_unstemmed |
Active Surveillance of Candidemia, Australia |
title_sort |
active surveillance of candidemia, australia |
publisher |
Centers for Disease Control and Prevention |
series |
Emerging Infectious Diseases |
issn |
1080-6040 1080-6059 |
publishDate |
2006-10-01 |
description |
Population-based surveillance for candidemia in Australia from 2001 to 2004 identified 1,095 cases. Annual overall and hospital-specific incidences were 1.81/100,000 and 0.21/1,000 separations (completed admissions), respectively. Predisposing factors included malignancy (32.1%), indwelling vascular catheters (72.6%), use of antimicrobial agents (77%), and surgery (37.1%). Of 919 episodes, 81.5% were inpatient healthcare associated (IHCA), 11.6% were outpatient healthcare associated (OHCA), and 6.9% were community acquired (CA). Concomitant illnesses and risk factors were similar in IHCA and OHCA candidemia. IHCA candidemia was associated with sepsis at diagnosis (p<0.001), death <30 days after infection (p<0.001), and prolonged hospital admission (p<0.001). Non–Candida albicans species (52.7%) caused 60.5% of cases acquired outside hospitals and 49.9% of IHCA candidemia (p = 0.02). The 30-day death rate was 27.7% in those >65 years of age. Adult critical care stay, sepsis syndrome, and corticosteroid therapy were associated with the greatest risk for death. Systematic epidemiologic studies that use standardized definitions for IHCA, OHCA, and CA candidemia are indicated. |
topic |
Population-based candidemia surveillance epidemiology Australia healthcare-associated |
url |
https://wwwnc.cdc.gov/eid/article/12/10/06-0389_article |
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