Lunasin alleviates allergic airway inflammation while increases antigen-specific Tregs.
Lunasin is a naturally occurring peptide isolated from soybeans and has been explored in cancer treatment. Lunasin inhibits NF-κB activation and thus pro-inflammatory cytokine and mediator production in macrophages. In this study we demonstrate that lunasin can effectively suppress allergic airway i...
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doaj-809473207fb646e987733c9414f5148d2020-11-24T22:16:54ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01102e011533010.1371/journal.pone.0115330Lunasin alleviates allergic airway inflammation while increases antigen-specific Tregs.Xiaowei YangJingjing ZhuChun-Yu TungGail GardinerQun WangHua-Chen ChangBaohua ZhouLunasin is a naturally occurring peptide isolated from soybeans and has been explored in cancer treatment. Lunasin inhibits NF-κB activation and thus pro-inflammatory cytokine and mediator production in macrophages. In this study we demonstrate that lunasin can effectively suppress allergic airway inflammation in two murine models of asthma. In an OVA+Alum sensitization model, intranasal lunasin treatment at the time of OVA challenges significantly reduced total cells counts in bronchoalveolar lavage (BAL) fluid and eosinophilia, peribronchiolar inflammatory infiltration, goblet cell metaplasia and airway IL-4 production. In an OVA+LPS intranasal sensitization model, lunasin treatment either at the time of sensitization or challenge has similar effects in suppress allergic airway inflammation including significantly reduced total cell and eosinophil counts in BAL fluid, inflammatory gene Fizz1 expression in the lung, and IL-4 production by OVA re-stimulated cells from mediastinal lymph nodes. We further show that intranasal instillation of OVA+lunasin significantly increases OVA-specific regulatory T cell (Treg) accumulation in the lung comparing to OVA only treatment. Taken together, our results suggest lunasin as an anti-inflammatory agent can be potentially used in asthma therapy or as an adjuvant to enhance the induction of antigen-specific Tregs and thus boost the efficacy of allergy immunotherapy.http://europepmc.org/articles/PMC4315393?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Xiaowei Yang Jingjing Zhu Chun-Yu Tung Gail Gardiner Qun Wang Hua-Chen Chang Baohua Zhou |
spellingShingle |
Xiaowei Yang Jingjing Zhu Chun-Yu Tung Gail Gardiner Qun Wang Hua-Chen Chang Baohua Zhou Lunasin alleviates allergic airway inflammation while increases antigen-specific Tregs. PLoS ONE |
author_facet |
Xiaowei Yang Jingjing Zhu Chun-Yu Tung Gail Gardiner Qun Wang Hua-Chen Chang Baohua Zhou |
author_sort |
Xiaowei Yang |
title |
Lunasin alleviates allergic airway inflammation while increases antigen-specific Tregs. |
title_short |
Lunasin alleviates allergic airway inflammation while increases antigen-specific Tregs. |
title_full |
Lunasin alleviates allergic airway inflammation while increases antigen-specific Tregs. |
title_fullStr |
Lunasin alleviates allergic airway inflammation while increases antigen-specific Tregs. |
title_full_unstemmed |
Lunasin alleviates allergic airway inflammation while increases antigen-specific Tregs. |
title_sort |
lunasin alleviates allergic airway inflammation while increases antigen-specific tregs. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2015-01-01 |
description |
Lunasin is a naturally occurring peptide isolated from soybeans and has been explored in cancer treatment. Lunasin inhibits NF-κB activation and thus pro-inflammatory cytokine and mediator production in macrophages. In this study we demonstrate that lunasin can effectively suppress allergic airway inflammation in two murine models of asthma. In an OVA+Alum sensitization model, intranasal lunasin treatment at the time of OVA challenges significantly reduced total cells counts in bronchoalveolar lavage (BAL) fluid and eosinophilia, peribronchiolar inflammatory infiltration, goblet cell metaplasia and airway IL-4 production. In an OVA+LPS intranasal sensitization model, lunasin treatment either at the time of sensitization or challenge has similar effects in suppress allergic airway inflammation including significantly reduced total cell and eosinophil counts in BAL fluid, inflammatory gene Fizz1 expression in the lung, and IL-4 production by OVA re-stimulated cells from mediastinal lymph nodes. We further show that intranasal instillation of OVA+lunasin significantly increases OVA-specific regulatory T cell (Treg) accumulation in the lung comparing to OVA only treatment. Taken together, our results suggest lunasin as an anti-inflammatory agent can be potentially used in asthma therapy or as an adjuvant to enhance the induction of antigen-specific Tregs and thus boost the efficacy of allergy immunotherapy. |
url |
http://europepmc.org/articles/PMC4315393?pdf=render |
work_keys_str_mv |
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