Asthma heterogeneity and severity

Asthma heterogeneity and severity

Asthma is a common, chronic inflammatory airways disease characterized by a clinical syndrome of bronchial hyperresponsiveness, inflammation, and reversible airflow obstruction. Individuals with asthma can vary widely in clinical presentation, severity, and pathobiology. The incident factors, pathog...

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Main Authors: Tara F. Carr, Eugene Bleecker
Format: Article
Language:English
Published: Elsevier 2016-01-01
Series:World Allergy Organization Journal
Online Access:http://www.sciencedirect.com/science/article/pii/S1939455119301966
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spelling doaj-809e53ba84f140028fa9a3191798b1652020-11-24T21:49:18ZengElsevierWorld Allergy Organization Journal1939-45512016-01-019Asthma heterogeneity and severityTara F. Carr0Eugene Bleecker1Asthma and Airway Disease Research Center, University of Arizona, 1501 N Campbell Ave, Tucson, AZ 85724-5030, USA.; Correspondence:Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, NC, USA.Asthma is a common, chronic inflammatory airways disease characterized by a clinical syndrome of bronchial hyperresponsiveness, inflammation, and reversible airflow obstruction. Individuals with asthma can vary widely in clinical presentation, severity, and pathobiology. The incident factors, pathogenesis, prognosis, and treatment of asthma remain incompletely understood. Utilizing measurable characteristics of asthmatic patients, including demographic, physiologic, and biologic markers, can however identify meaningful phenotypic categories in asthma. Identification of these phenotypes may help improve precision therapeutics targeted toward an individual’s’ disease, and may identify strategies for preventing progression of disease severity. Keywords: Severe asthma, Phenotype, Heterogeneityhttp://www.sciencedirect.com/science/article/pii/S1939455119301966
collection DOAJ
language English
format Article
sources DOAJ
author Tara F. Carr
Eugene Bleecker
spellingShingle Tara F. Carr
Eugene Bleecker
Asthma heterogeneity and severity
World Allergy Organization Journal
author_facet Tara F. Carr
Eugene Bleecker
author_sort Tara F. Carr
title Asthma heterogeneity and severity
title_short Asthma heterogeneity and severity
title_full Asthma heterogeneity and severity
title_fullStr Asthma heterogeneity and severity
title_full_unstemmed Asthma heterogeneity and severity
title_sort asthma heterogeneity and severity
publisher Elsevier
series World Allergy Organization Journal
issn 1939-4551
publishDate 2016-01-01
description Asthma is a common, chronic inflammatory airways disease characterized by a clinical syndrome of bronchial hyperresponsiveness, inflammation, and reversible airflow obstruction. Individuals with asthma can vary widely in clinical presentation, severity, and pathobiology. The incident factors, pathogenesis, prognosis, and treatment of asthma remain incompletely understood. Utilizing measurable characteristics of asthmatic patients, including demographic, physiologic, and biologic markers, can however identify meaningful phenotypic categories in asthma. Identification of these phenotypes may help improve precision therapeutics targeted toward an individual’s’ disease, and may identify strategies for preventing progression of disease severity. Keywords: Severe asthma, Phenotype, Heterogeneity
url http://www.sciencedirect.com/science/article/pii/S1939455119301966
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AT eugenebleecker asthmaheterogeneityandseverity
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