Placental Glucose Transporters and Response to Bisphenol A in Pregnancies from of Normal and Overweight Mothers
Bisphenol A (BPA) is a synthetic phenol extensively used in the manufacture of polycarbonate plastics and epoxy resins and a component of liquid and food storages. Among health disorders potentially attributed to BPA, the effects on metabolism have been especially studied. BPA represents a hazard in...
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doaj-80a271b509da4dd7a91d377e134005762021-07-01T00:45:14ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-06-01226625662510.3390/ijms22126625Placental Glucose Transporters and Response to Bisphenol A in Pregnancies from of Normal and Overweight MothersLeonardo Ermini0Anna Maria Nuzzo1Francesca Ietta2Roberta Romagnoli3Laura Moretti4Bianca Masturzo5Luana Paulesu6Alessandro Rolfo7Department of Life Sciences, University of Siena, 53100 Siena, ItalyDepartment of Surgical Sciences, University of Turin, Via Ventimiglia 3, 10126 Turin, ItalyDepartment of Life Sciences, University of Siena, 53100 Siena, ItalyDepartment of Life Sciences, University of Siena, 53100 Siena, ItalyDepartment of Surgical Sciences, University of Turin, Via Ventimiglia 3, 10126 Turin, ItalyCittà della Salute e della Scienza, Sant’Anna University Hospital, University of Turin, 10126 Turin, ItalyDepartment of Life Sciences, University of Siena, 53100 Siena, ItalyDepartment of Surgical Sciences, University of Turin, Via Ventimiglia 3, 10126 Turin, ItalyBisphenol A (BPA) is a synthetic phenol extensively used in the manufacture of polycarbonate plastics and epoxy resins and a component of liquid and food storages. Among health disorders potentially attributed to BPA, the effects on metabolism have been especially studied. BPA represents a hazard in prenatal life because of its presence in tissues and fluids during pregnancy. Our recent study in rats fed with BPA showed a placental increase in glucose type 1 transporter (GLUT-1), suggesting a higher uptake of glucose. However, the role of BPA on GLUT transporters in pregnant women with metabolic dysfunction has not yet been investigated. In this study, placental tissue from 26 overweight (OW) women and 32 age-matched normal weight (NW) pregnant women were examined for expression of GLUT1 and GLUT4. Placental explants from OW and NW mothers were exposed to BPA 1 nM and 1 μM and tested for GLUTs expression. The data showed a different response of placental explants to BPA in GLUT1 expression with an increase in NW mothers and a decrease in OW ones. GLUT4 expression was lower in the explants from OW than NW mothers, while no difference was showed between OW and NW in placental biopsies for any of the transporters.https://www.mdpi.com/1422-0067/22/12/6625BPAGLUT1GLUT4human pregnancyhuman placenta |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Leonardo Ermini Anna Maria Nuzzo Francesca Ietta Roberta Romagnoli Laura Moretti Bianca Masturzo Luana Paulesu Alessandro Rolfo |
spellingShingle |
Leonardo Ermini Anna Maria Nuzzo Francesca Ietta Roberta Romagnoli Laura Moretti Bianca Masturzo Luana Paulesu Alessandro Rolfo Placental Glucose Transporters and Response to Bisphenol A in Pregnancies from of Normal and Overweight Mothers International Journal of Molecular Sciences BPA GLUT1 GLUT4 human pregnancy human placenta |
author_facet |
Leonardo Ermini Anna Maria Nuzzo Francesca Ietta Roberta Romagnoli Laura Moretti Bianca Masturzo Luana Paulesu Alessandro Rolfo |
author_sort |
Leonardo Ermini |
title |
Placental Glucose Transporters and Response to Bisphenol A in Pregnancies from of Normal and Overweight Mothers |
title_short |
Placental Glucose Transporters and Response to Bisphenol A in Pregnancies from of Normal and Overweight Mothers |
title_full |
Placental Glucose Transporters and Response to Bisphenol A in Pregnancies from of Normal and Overweight Mothers |
title_fullStr |
Placental Glucose Transporters and Response to Bisphenol A in Pregnancies from of Normal and Overweight Mothers |
title_full_unstemmed |
Placental Glucose Transporters and Response to Bisphenol A in Pregnancies from of Normal and Overweight Mothers |
title_sort |
placental glucose transporters and response to bisphenol a in pregnancies from of normal and overweight mothers |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1661-6596 1422-0067 |
publishDate |
2021-06-01 |
description |
Bisphenol A (BPA) is a synthetic phenol extensively used in the manufacture of polycarbonate plastics and epoxy resins and a component of liquid and food storages. Among health disorders potentially attributed to BPA, the effects on metabolism have been especially studied. BPA represents a hazard in prenatal life because of its presence in tissues and fluids during pregnancy. Our recent study in rats fed with BPA showed a placental increase in glucose type 1 transporter (GLUT-1), suggesting a higher uptake of glucose. However, the role of BPA on GLUT transporters in pregnant women with metabolic dysfunction has not yet been investigated. In this study, placental tissue from 26 overweight (OW) women and 32 age-matched normal weight (NW) pregnant women were examined for expression of GLUT1 and GLUT4. Placental explants from OW and NW mothers were exposed to BPA 1 nM and 1 μM and tested for GLUTs expression. The data showed a different response of placental explants to BPA in GLUT1 expression with an increase in NW mothers and a decrease in OW ones. GLUT4 expression was lower in the explants from OW than NW mothers, while no difference was showed between OW and NW in placental biopsies for any of the transporters. |
topic |
BPA GLUT1 GLUT4 human pregnancy human placenta |
url |
https://www.mdpi.com/1422-0067/22/12/6625 |
work_keys_str_mv |
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