Rapidly Progressive Pancreatic Lipomatosis in a Young Adult Patient with Transfusion-dependent Myelodysplastic Syndrome
Pancreatic lipomatosis is defined as deposition of fat cells in pancreatic parenchyma. Although the etiology of this condition is still unclear, it is not uncommon in the elderly obese individuals, and a variety of transfusion-dependent hematologic diseases such as β-thalassemia major. Pancreatic li...
Main Authors: | , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2007-08-01
|
Series: | Journal of the Formosan Medical Association |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S0929664608600273 |
id |
doaj-80b974cf8f164d4db1042cacbbe02c66 |
---|---|
record_format |
Article |
spelling |
doaj-80b974cf8f164d4db1042cacbbe02c662020-11-24T22:10:09ZengElsevierJournal of the Formosan Medical Association0929-66462007-08-01106867667910.1016/S0929-6646(08)60027-3Rapidly Progressive Pancreatic Lipomatosis in a Young Adult Patient with Transfusion-dependent Myelodysplastic SyndromeWei-Ching Lin0Jeon-Hor Chen1Chien-Heng Lin2Wu-Chung Shen3Department of Radiology, China Medical University Hospital, Taichung, TaiwanDepartment of Radiology, China Medical University Hospital, Taichung, TaiwanDepartment of Pediatrics, Jen-Ai Hospital, Taichung, TaiwanDepartment of Radiology, China Medical University Hospital, Taichung, TaiwanPancreatic lipomatosis is defined as deposition of fat cells in pancreatic parenchyma. Although the etiology of this condition is still unclear, it is not uncommon in the elderly obese individuals, and a variety of transfusion-dependent hematologic diseases such as β-thalassemia major. Pancreatic lipomatosis associated with transfusion-dependent myelodysplastic syndrome (MDS) has never been reported. We present a 17-year-old male patient with transfusion-dependent MDS. He received transfusion of a total of 345 units of blood in a period of 18 months but without iron chelating agent. Progressive fatty replacement of the pancreas parenchyma was found by a series of computed tomography images over seven hospital admissions due to repeated infections. Bone marrow biopsy revealed hemosiderin deposition. Because of his poor response to induction chemotherapy, stem cell transplantation was suggested, but the patient died of sepsis before the therapeutic procedure could take place. Although most patients with pancreatic lipomatosis have neither clinical symptoms nor abnormal laboratory data, it may cause endocrine and exocrine pancreas dysfunction. In this reported case, mild exocrine dysfunction was noted on the last admission. Clinicians should be cautious of hemosiderin deposition after large amount of blood transfusion and chelating therapy should be given to avoid iron overload.http://www.sciencedirect.com/science/article/pii/S0929664608600273blood transfusionlipomatosismyelodysplastic syndromepancreas |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Wei-Ching Lin Jeon-Hor Chen Chien-Heng Lin Wu-Chung Shen |
spellingShingle |
Wei-Ching Lin Jeon-Hor Chen Chien-Heng Lin Wu-Chung Shen Rapidly Progressive Pancreatic Lipomatosis in a Young Adult Patient with Transfusion-dependent Myelodysplastic Syndrome Journal of the Formosan Medical Association blood transfusion lipomatosis myelodysplastic syndrome pancreas |
author_facet |
Wei-Ching Lin Jeon-Hor Chen Chien-Heng Lin Wu-Chung Shen |
author_sort |
Wei-Ching Lin |
title |
Rapidly Progressive Pancreatic Lipomatosis in a Young Adult Patient with Transfusion-dependent Myelodysplastic Syndrome |
title_short |
Rapidly Progressive Pancreatic Lipomatosis in a Young Adult Patient with Transfusion-dependent Myelodysplastic Syndrome |
title_full |
Rapidly Progressive Pancreatic Lipomatosis in a Young Adult Patient with Transfusion-dependent Myelodysplastic Syndrome |
title_fullStr |
Rapidly Progressive Pancreatic Lipomatosis in a Young Adult Patient with Transfusion-dependent Myelodysplastic Syndrome |
title_full_unstemmed |
Rapidly Progressive Pancreatic Lipomatosis in a Young Adult Patient with Transfusion-dependent Myelodysplastic Syndrome |
title_sort |
rapidly progressive pancreatic lipomatosis in a young adult patient with transfusion-dependent myelodysplastic syndrome |
publisher |
Elsevier |
series |
Journal of the Formosan Medical Association |
issn |
0929-6646 |
publishDate |
2007-08-01 |
description |
Pancreatic lipomatosis is defined as deposition of fat cells in pancreatic parenchyma. Although the etiology of this condition is still unclear, it is not uncommon in the elderly obese individuals, and a variety of transfusion-dependent hematologic diseases such as β-thalassemia major. Pancreatic lipomatosis associated with transfusion-dependent myelodysplastic syndrome (MDS) has never been reported. We present a 17-year-old male patient with transfusion-dependent MDS. He received transfusion of a total of 345 units of blood in a period of 18 months but without iron chelating agent. Progressive fatty replacement of the pancreas parenchyma was found by a series of computed tomography images over seven hospital admissions due to repeated infections. Bone marrow biopsy revealed hemosiderin deposition. Because of his poor response to induction chemotherapy, stem cell transplantation was suggested, but the patient died of sepsis before the therapeutic procedure could take place. Although most patients with pancreatic lipomatosis have neither clinical symptoms nor abnormal laboratory data, it may cause endocrine and exocrine pancreas dysfunction. In this reported case, mild exocrine dysfunction was noted on the last admission. Clinicians should be cautious of hemosiderin deposition after large amount of blood transfusion and chelating therapy should be given to avoid iron overload. |
topic |
blood transfusion lipomatosis myelodysplastic syndrome pancreas |
url |
http://www.sciencedirect.com/science/article/pii/S0929664608600273 |
work_keys_str_mv |
AT weichinglin rapidlyprogressivepancreaticlipomatosisinayoungadultpatientwithtransfusiondependentmyelodysplasticsyndrome AT jeonhorchen rapidlyprogressivepancreaticlipomatosisinayoungadultpatientwithtransfusiondependentmyelodysplasticsyndrome AT chienhenglin rapidlyprogressivepancreaticlipomatosisinayoungadultpatientwithtransfusiondependentmyelodysplasticsyndrome AT wuchungshen rapidlyprogressivepancreaticlipomatosisinayoungadultpatientwithtransfusiondependentmyelodysplasticsyndrome |
_version_ |
1725809031335903232 |