Serum inflammatory cytokines combined with NIHSS to evaluate the condition of patients with acute ischemic stroke
<strong>Objective</strong> To explore the changes of serum inflammatory cytokines and National Institute of Health Stroke Scale (NIHSS) score in acute ischemic stroke patients and their clinical significances on patients' condition assessment. <strong>Methods</strong> Th...
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Tianjin Huanhu Hospital
2013-09-01
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Online Access: | http://www.cjcnn.org/index.php/cjcnn/article/view/807 |
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doaj-80beacd61ef24c2b9bb13fff576babe62020-11-25T01:19:06ZengTianjin Huanhu HospitalChinese Journal of Contemporary Neurology and Neurosurgery1672-67312013-09-01139801804806Serum inflammatory cytokines combined with NIHSS to evaluate the condition of patients with acute ischemic strokeHeng YUChong-rong LONGLiang WANG<strong>Objective</strong> To explore the changes of serum inflammatory cytokines and National Institute of Health Stroke Scale (NIHSS) score in acute ischemic stroke patients and their clinical significances on patients' condition assessment. <strong>Methods</strong> The serum levels of three cytokines, including interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and high⁃sensitivity C-reactive protein (hs-CRP), were measured and compared between 90 acute ischemic stroke patients (ischemic stroke group) and 50 healthy people (normal control group). The above-mentioned three cytokines and NIHSS scores were compared between before and after treatment in ischemic stroke group. <strong>Results</strong> Patients in ischemic stroke group were divided into three subgroups according to different infarct sizes: large (> 10 cm3), medium (5-10 cm3) and small (< 5 cm3). The serum levels of three cytokines were significantly higher in three subgroups than those in the normal control group before treatment (P < 0.01). Compared with before treatment, both the serum levels of three cytokines and the NIHSS scores in ishemic stroke patients reduced significantly after treatment (P < 0.01, for all). <strong>Conclusion</strong> Serum levels of inflammatory cytokines and NIHSS scores in patients with acute ischemic stroke can be used for condition assessment and efficacy monitoring. <br />http://www.cjcnn.org/index.php/cjcnn/article/view/807Brain ischemiaInterleukin-6Tumor necrosis factor-alphaC-reactive protein |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Heng YU Chong-rong LONG Liang WANG |
spellingShingle |
Heng YU Chong-rong LONG Liang WANG Serum inflammatory cytokines combined with NIHSS to evaluate the condition of patients with acute ischemic stroke Chinese Journal of Contemporary Neurology and Neurosurgery Brain ischemia Interleukin-6 Tumor necrosis factor-alpha C-reactive protein |
author_facet |
Heng YU Chong-rong LONG Liang WANG |
author_sort |
Heng YU |
title |
Serum inflammatory cytokines combined with NIHSS to evaluate the condition of patients with acute ischemic stroke |
title_short |
Serum inflammatory cytokines combined with NIHSS to evaluate the condition of patients with acute ischemic stroke |
title_full |
Serum inflammatory cytokines combined with NIHSS to evaluate the condition of patients with acute ischemic stroke |
title_fullStr |
Serum inflammatory cytokines combined with NIHSS to evaluate the condition of patients with acute ischemic stroke |
title_full_unstemmed |
Serum inflammatory cytokines combined with NIHSS to evaluate the condition of patients with acute ischemic stroke |
title_sort |
serum inflammatory cytokines combined with nihss to evaluate the condition of patients with acute ischemic stroke |
publisher |
Tianjin Huanhu Hospital |
series |
Chinese Journal of Contemporary Neurology and Neurosurgery |
issn |
1672-6731 |
publishDate |
2013-09-01 |
description |
<strong>Objective</strong> To explore the changes of serum inflammatory cytokines and National Institute of Health Stroke Scale (NIHSS) score in acute ischemic stroke patients and their clinical significances on patients' condition assessment. <strong>Methods</strong> The serum levels of three cytokines, including interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and high⁃sensitivity C-reactive protein (hs-CRP), were measured and compared between 90 acute ischemic stroke patients (ischemic stroke group) and 50 healthy people (normal control group). The above-mentioned three cytokines and NIHSS scores were compared between before and after treatment in ischemic stroke group. <strong>Results</strong> Patients in ischemic stroke group were divided into three subgroups according to different infarct sizes: large (> 10 cm3), medium (5-10 cm3) and small (< 5 cm3). The serum levels of three cytokines were significantly higher in three subgroups than those in the normal control group before treatment (P < 0.01). Compared with before treatment, both the serum levels of three cytokines and the NIHSS scores in ishemic stroke patients reduced significantly after treatment (P < 0.01, for all). <strong>Conclusion</strong> Serum levels of inflammatory cytokines and NIHSS scores in patients with acute ischemic stroke can be used for condition assessment and efficacy monitoring. <br /> |
topic |
Brain ischemia Interleukin-6 Tumor necrosis factor-alpha C-reactive protein |
url |
http://www.cjcnn.org/index.php/cjcnn/article/view/807 |
work_keys_str_mv |
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