Protective Effect of Prunus Cerasus (Sour Cherry) Seed Extract on the Recovery of Ischemia/Reperfusion-Induced Retinal Damage in Zucker Diabetic Fatty Rat
Among diabetes patients, ophthalmological complications are very frequent. High blood glucose and (consequential) ischemia-reperfusion (I/R) injury contribute significantly to the severity of retinopathies. Diabetic retinopathy is among the leading causes of blindness. Our study demonstrates the eff...
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doaj-80c1599584624dce8c513f5b3538b67a2020-11-24T20:46:39ZengMDPI AGMolecules1420-30492017-10-012210178210.3390/molecules22101782molecules22101782Protective Effect of Prunus Cerasus (Sour Cherry) Seed Extract on the Recovery of Ischemia/Reperfusion-Induced Retinal Damage in Zucker Diabetic Fatty RatBalázs Varga0Dániel Priksz1Nóra Lampé2Mariann Bombicz3Andrea Kurucz4Adrienn Mónika Szabó5Anikó Pósa6Renáta Szabó7Ádám Kemény-Beke8Judit Remenyik9Rudolf Gesztelyi10Béla Juhász11Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Debrecen, Debrecen H4032, HungaryDepartment of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Debrecen, Debrecen H4032, HungaryDepartment of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Debrecen, Debrecen H4032, HungaryDepartment of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Debrecen, Debrecen H4032, HungaryDepartment of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Debrecen, Debrecen H4032, HungaryDepartment of Internal Medicine, Building C, Faculty of Medicine, University of Debrecen, Debrecen H4032, HungaryDepartment of Physiology, Anatomy and Neuroscience, Faculty of Science and Informatics, University of Szeged, Szeged H6726, HungaryDepartment of Physiology, Anatomy and Neuroscience, Faculty of Science and Informatics, University of Szeged, Szeged H6726, HungaryDepartment of Ophtalmology, Faculty of Medicine, University of Debrecen, Debrecen H4032, HungaryInstitute of Food Technology, Faculty of Agricultural and Food Sciences and Environmental Management, University of Debrecen, Debrecen H4032, HungaryDepartment of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Debrecen, Debrecen H4032, HungaryDepartment of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Debrecen, Debrecen H4032, HungaryAmong diabetes patients, ophthalmological complications are very frequent. High blood glucose and (consequential) ischemia-reperfusion (I/R) injury contribute significantly to the severity of retinopathies. Diabetic retinopathy is among the leading causes of blindness. Our study demonstrates the effect of sour cherry seed extract (SCSE) on blood glucose and function of the retina with electroretinography (ERG) in a diabetic setting with or without ischemia-reperfusion (I/R) injury in Zucker Diabetic Fatty (ZDF) rats. Our results prove that the SCSE has a retinoprotective effect in diabetic rats: according to ERG measurements, SCSE treatment mitigated the retinal function-damaging effect of diabetes, and proved to be protective in the diabetic eye against ischemia-reperfusion injuries of the retina. Outcomes suggest that the protective effects of SCSE may occur through several pathways, including HO-1 dependent mechanisms. The observation that SCSE treatment decreases blood glucose is also novel. These findings offer the possibility for development of novel therapeutic strategies utilizing this emerging functional food, in particular in the prevention of conditions resulting from high blood glucose or I/R injury, such as deterioration of retinal microcirculation.https://www.mdpi.com/1420-3049/22/10/1782Prunus cerasussour cherryischemia-reperfusionretinaelectroretinographyZDF rat |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Balázs Varga Dániel Priksz Nóra Lampé Mariann Bombicz Andrea Kurucz Adrienn Mónika Szabó Anikó Pósa Renáta Szabó Ádám Kemény-Beke Judit Remenyik Rudolf Gesztelyi Béla Juhász |
spellingShingle |
Balázs Varga Dániel Priksz Nóra Lampé Mariann Bombicz Andrea Kurucz Adrienn Mónika Szabó Anikó Pósa Renáta Szabó Ádám Kemény-Beke Judit Remenyik Rudolf Gesztelyi Béla Juhász Protective Effect of Prunus Cerasus (Sour Cherry) Seed Extract on the Recovery of Ischemia/Reperfusion-Induced Retinal Damage in Zucker Diabetic Fatty Rat Molecules Prunus cerasus sour cherry ischemia-reperfusion retina electroretinography ZDF rat |
author_facet |
Balázs Varga Dániel Priksz Nóra Lampé Mariann Bombicz Andrea Kurucz Adrienn Mónika Szabó Anikó Pósa Renáta Szabó Ádám Kemény-Beke Judit Remenyik Rudolf Gesztelyi Béla Juhász |
author_sort |
Balázs Varga |
title |
Protective Effect of Prunus Cerasus (Sour Cherry) Seed Extract on the Recovery of Ischemia/Reperfusion-Induced Retinal Damage in Zucker Diabetic Fatty Rat |
title_short |
Protective Effect of Prunus Cerasus (Sour Cherry) Seed Extract on the Recovery of Ischemia/Reperfusion-Induced Retinal Damage in Zucker Diabetic Fatty Rat |
title_full |
Protective Effect of Prunus Cerasus (Sour Cherry) Seed Extract on the Recovery of Ischemia/Reperfusion-Induced Retinal Damage in Zucker Diabetic Fatty Rat |
title_fullStr |
Protective Effect of Prunus Cerasus (Sour Cherry) Seed Extract on the Recovery of Ischemia/Reperfusion-Induced Retinal Damage in Zucker Diabetic Fatty Rat |
title_full_unstemmed |
Protective Effect of Prunus Cerasus (Sour Cherry) Seed Extract on the Recovery of Ischemia/Reperfusion-Induced Retinal Damage in Zucker Diabetic Fatty Rat |
title_sort |
protective effect of prunus cerasus (sour cherry) seed extract on the recovery of ischemia/reperfusion-induced retinal damage in zucker diabetic fatty rat |
publisher |
MDPI AG |
series |
Molecules |
issn |
1420-3049 |
publishDate |
2017-10-01 |
description |
Among diabetes patients, ophthalmological complications are very frequent. High blood glucose and (consequential) ischemia-reperfusion (I/R) injury contribute significantly to the severity of retinopathies. Diabetic retinopathy is among the leading causes of blindness. Our study demonstrates the effect of sour cherry seed extract (SCSE) on blood glucose and function of the retina with electroretinography (ERG) in a diabetic setting with or without ischemia-reperfusion (I/R) injury in Zucker Diabetic Fatty (ZDF) rats. Our results prove that the SCSE has a retinoprotective effect in diabetic rats: according to ERG measurements, SCSE treatment mitigated the retinal function-damaging effect of diabetes, and proved to be protective in the diabetic eye against ischemia-reperfusion injuries of the retina. Outcomes suggest that the protective effects of SCSE may occur through several pathways, including HO-1 dependent mechanisms. The observation that SCSE treatment decreases blood glucose is also novel. These findings offer the possibility for development of novel therapeutic strategies utilizing this emerging functional food, in particular in the prevention of conditions resulting from high blood glucose or I/R injury, such as deterioration of retinal microcirculation. |
topic |
Prunus cerasus sour cherry ischemia-reperfusion retina electroretinography ZDF rat |
url |
https://www.mdpi.com/1420-3049/22/10/1782 |
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