Effects of a Diet Based on Foods from Symbiotic Agriculture on the Gut Microbiota of Subjects at Risk for Metabolic Syndrome
Diet is a major driver of gut microbiota variation and plays a role in metabolic disorders, including metabolic syndrome (MS). Mycorrhized foods from symbiotic agriculture (SA) exhibit improved nutritional properties, but potential benefits have never been investigated in humans. We conducted a pilo...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | Nutrients |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6643/13/6/2081 |
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Article |
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DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Silvia Turroni Elisabetta Petracci Valeria Edefonti Anna M. Giudetti Federica D’Amico Lisa Paganelli Giusto Giovannetti Laura Del Coco Francesco P. Fanizzi Simone Rampelli Debora Guerra Claudia Rengucci Jenny Bulgarelli Marcella Tazzari Nicoletta Pellegrini Monica Ferraroni Oriana Nanni Patrizia Serra |
| spellingShingle |
Silvia Turroni Elisabetta Petracci Valeria Edefonti Anna M. Giudetti Federica D’Amico Lisa Paganelli Giusto Giovannetti Laura Del Coco Francesco P. Fanizzi Simone Rampelli Debora Guerra Claudia Rengucci Jenny Bulgarelli Marcella Tazzari Nicoletta Pellegrini Monica Ferraroni Oriana Nanni Patrizia Serra Effects of a Diet Based on Foods from Symbiotic Agriculture on the Gut Microbiota of Subjects at Risk for Metabolic Syndrome Nutrients adult volunteers dietary intervention dietary patterns gut microbiota pilot study symbiotic agriculture |
| author_facet |
Silvia Turroni Elisabetta Petracci Valeria Edefonti Anna M. Giudetti Federica D’Amico Lisa Paganelli Giusto Giovannetti Laura Del Coco Francesco P. Fanizzi Simone Rampelli Debora Guerra Claudia Rengucci Jenny Bulgarelli Marcella Tazzari Nicoletta Pellegrini Monica Ferraroni Oriana Nanni Patrizia Serra |
| author_sort |
Silvia Turroni |
| title |
Effects of a Diet Based on Foods from Symbiotic Agriculture on the Gut Microbiota of Subjects at Risk for Metabolic Syndrome |
| title_short |
Effects of a Diet Based on Foods from Symbiotic Agriculture on the Gut Microbiota of Subjects at Risk for Metabolic Syndrome |
| title_full |
Effects of a Diet Based on Foods from Symbiotic Agriculture on the Gut Microbiota of Subjects at Risk for Metabolic Syndrome |
| title_fullStr |
Effects of a Diet Based on Foods from Symbiotic Agriculture on the Gut Microbiota of Subjects at Risk for Metabolic Syndrome |
| title_full_unstemmed |
Effects of a Diet Based on Foods from Symbiotic Agriculture on the Gut Microbiota of Subjects at Risk for Metabolic Syndrome |
| title_sort |
effects of a diet based on foods from symbiotic agriculture on the gut microbiota of subjects at risk for metabolic syndrome |
| publisher |
MDPI AG |
| series |
Nutrients |
| issn |
2072-6643 |
| publishDate |
2021-06-01 |
| description |
Diet is a major driver of gut microbiota variation and plays a role in metabolic disorders, including metabolic syndrome (MS). Mycorrhized foods from symbiotic agriculture (SA) exhibit improved nutritional properties, but potential benefits have never been investigated in humans. We conducted a pilot interventional study on 60 adults with ≥ 1 risk factors for MS, of whom 33 consumed SA-derived fresh foods and 27 received probiotics over 30 days, with a 15-day follow-up. Stool, urine and blood were collected over time to explore changes in gut microbiota, metabolome, and biochemical, inflammatory and immunologic parameters; previous dietary habits were investigated through a validated food-frequency questionnaire. The baseline microbiota showed alterations typical of metabolic disorders, mainly an increase in <i>Coriobacteriaceae</i> and a decrease in health-associated taxa, which were partly reversed after the SA-based diet. Improvements were observed in metabolome, MS presence (two out of six subjects no longer had MS) or components. Changes were more pronounced with less healthy baseline diets. Probiotics had a marginal, not entirely favorable, effect, although one out of three subjects no longer suffered from MS. These findings suggest that improved dietary patterns can modulate the host microbiota and metabolome, counteracting the risk of developing MS. |
| topic |
adult volunteers dietary intervention dietary patterns gut microbiota pilot study symbiotic agriculture |
| url |
https://www.mdpi.com/2072-6643/13/6/2081 |
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doaj-80cb4059f81549c191258934ea9b59262021-07-01T00:28:29ZengMDPI AGNutrients2072-66432021-06-01132081208110.3390/nu13062081Effects of a Diet Based on Foods from Symbiotic Agriculture on the Gut Microbiota of Subjects at Risk for Metabolic SyndromeSilvia Turroni0Elisabetta Petracci1Valeria Edefonti2Anna M. Giudetti3Federica D’Amico4Lisa Paganelli5Giusto Giovannetti6Laura Del Coco7Francesco P. Fanizzi8Simone Rampelli9Debora Guerra10Claudia Rengucci11Jenny Bulgarelli12Marcella Tazzari13Nicoletta Pellegrini14Monica Ferraroni15Oriana Nanni16Patrizia Serra17Department of Pharmacy and Biotechnology, University of Bologna, via Belmeloro, 6, 40126 Bologna, ItalyBiostatistics and Clinical Trial Unit, Istituto Romagnolo per lo Studio dei Tumori “Dino Amadori”—IRST S.r.l., IRCCS, via P. Maroncelli, 40, 47014 Meldola, ItalyBranch of Medical Statistics, Biometry, and Epidemiology “G.A. Maccacaro”, Department of Clinical Sciences and Community Health, Università degli Studi di Milano, via A. Vanzetti, 5, 20133 Milano, ItalyDepartment of Biological and Environmental Sciences and Technologies, University of Salento, via Province of Lecce—Monteroni, 73100 Lecce, ItalyDepartment of Pharmacy and Biotechnology, University of Bologna, via Belmeloro, 6, 40126 Bologna, ItalyDonna Impresa Coldiretti Forlì-Cesena e Rimini, via E. Forlanini, 11, 47121 Forli, ItalyCentro Colture Sperimentali, CCS Aosta S.r.l., Frazione Olleyes 9, 11020 Quart, ItalyDepartment of Biological and Environmental Sciences and Technologies, University of Salento, via Province of Lecce—Monteroni, 73100 Lecce, ItalyDepartment of Biological and Environmental Sciences and Technologies, University of Salento, via Province of Lecce—Monteroni, 73100 Lecce, ItalyDepartment of Pharmacy and Biotechnology, University of Bologna, via Belmeloro, 6, 40126 Bologna, ItalyDepartment of Medical Oncology, Istituto Romagnolo per lo Studio dei Tumori “Dino Amadori”—IRST S.r.l., IRCCS, via P. Maroncelli, 40, 47014 Meldola, ItalyBioscience Laboratory, Istituto Romagnolo per lo Studio dei Tumori “Dino Amadori”—IRST S.r.l., IRCCS, via P. Maroncelli, 40, 47014 Meldola, ItalyImmunotherapy, Cell Therapy and Biobank Unit, Istituto Romagnolo per lo Studio dei Tumori “Dino Amadori”—IRST S.r.l., IRCCS, via P. Maroncelli, 40, 47014 Meldola, ItalyImmunotherapy, Cell Therapy and Biobank Unit, Istituto Romagnolo per lo Studio dei Tumori “Dino Amadori”—IRST S.r.l., IRCCS, via P. Maroncelli, 40, 47014 Meldola, ItalyDepartment of Agricultural, Food, Environmental and Animal Sciences, Università di Udine, via delle Scienze 206, 33100 Udine, ItalyBranch of Medical Statistics, Biometry, and Epidemiology “G.A. Maccacaro”, Department of Clinical Sciences and Community Health, Università degli Studi di Milano, via A. Vanzetti, 5, 20133 Milano, ItalyBiostatistics and Clinical Trial Unit, Istituto Romagnolo per lo Studio dei Tumori “Dino Amadori”—IRST S.r.l., IRCCS, via P. Maroncelli, 40, 47014 Meldola, ItalyBiostatistics and Clinical Trial Unit, Istituto Romagnolo per lo Studio dei Tumori “Dino Amadori”—IRST S.r.l., IRCCS, via P. Maroncelli, 40, 47014 Meldola, ItalyDiet is a major driver of gut microbiota variation and plays a role in metabolic disorders, including metabolic syndrome (MS). Mycorrhized foods from symbiotic agriculture (SA) exhibit improved nutritional properties, but potential benefits have never been investigated in humans. We conducted a pilot interventional study on 60 adults with ≥ 1 risk factors for MS, of whom 33 consumed SA-derived fresh foods and 27 received probiotics over 30 days, with a 15-day follow-up. Stool, urine and blood were collected over time to explore changes in gut microbiota, metabolome, and biochemical, inflammatory and immunologic parameters; previous dietary habits were investigated through a validated food-frequency questionnaire. The baseline microbiota showed alterations typical of metabolic disorders, mainly an increase in <i>Coriobacteriaceae</i> and a decrease in health-associated taxa, which were partly reversed after the SA-based diet. Improvements were observed in metabolome, MS presence (two out of six subjects no longer had MS) or components. Changes were more pronounced with less healthy baseline diets. Probiotics had a marginal, not entirely favorable, effect, although one out of three subjects no longer suffered from MS. These findings suggest that improved dietary patterns can modulate the host microbiota and metabolome, counteracting the risk of developing MS.https://www.mdpi.com/2072-6643/13/6/2081adult volunteersdietary interventiondietary patternsgut microbiotapilot studysymbiotic agriculture |