Abnormal resting-state functional network centrality in patients with high myopia: evidence from a voxel-wise degree centrality analysis
AIM: To investigate the functional networks underlying the brain-activity changes of patients with high myopia using the voxel-wise degree centrality (DC) method. METHODS: In total, 38 patients with high myopia (HM) (17 males and 21 females), whose binocular refractive diopter were -6.00 to -7.00 D...
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doaj-80d9c658f4384992a4bec2422403a1e82020-11-25T00:40:32ZengPress of International Journal of Ophthalmology (IJO PRESS)International Journal of Ophthalmology2222-39592227-48982018-11-0111111814182010.18240/ijo.2018.11.13Abnormal resting-state functional network centrality in patients with high myopia: evidence from a voxel-wise degree centrality analysisYu-Xiang Hu0Jun-Rong He1Bo Yang2Xin Huang3Yu-Ping Li4Fu-Qing Zhou5Xiao-Xuan Xu6Yu-Lin Zhong7Jun Wang8Xiao-Rong Wu9Department of Ophthalmology, the First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, ChinaDepartment of Quality Management Office, the Affiliated Ganzhou Hospital of Nanchang University, Ganzhou 341000, Jiangxi Province, ChinaDepartment of Ophthalmology, Xinjiang People’s Hospital, Urumqi 830000, Xinjiang Uygur Autonomous Region, ChinaDepartment of Ophthalmology, the First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, ChinaDepartment of Ophthalmology, Dongxiang People’s Hospital, Fuzhou 344000, Jiangxi Province, ChinaDepartment of Radiology, the First Affiliated Hospital of Nanchang University, Jiangxi Province Medical Imaging Research Institute, Nanchang 330006, Jiangxi Province, ChinaDepartment of Ophthalmology, the First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, ChinaDepartment of Ophthalmology, the First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, ChinaSecond Department of Respiratory Disease, Jiangxi Provincial People’s Hospital, Nanchang 330006, Jiangxi Province, ChinaDepartment of Ophthalmology, the First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, ChinaAIM: To investigate the functional networks underlying the brain-activity changes of patients with high myopia using the voxel-wise degree centrality (DC) method. METHODS: In total, 38 patients with high myopia (HM) (17 males and 21 females), whose binocular refractive diopter were -6.00 to -7.00 D, and 38 healthy controls (17 males and 21 females), closely matched in age, sex, and education levels, participated in the study. Spontaneous brain activities were evaluated using the voxel-wise DC method. The receiver operating characteristic curve was measured to distinguish patients with HM from healthy controls. Correlation analysis was used to explore the relationship between the observed mean DC values of the different brain areas and the behavioral performance. RESULTS: Compared with healthy controls, HM patients had significantly decreased DC values in the right inferior frontal gyrus/insula, right middle frontal gyrus, and right supramarginal/inferior parietal lobule (P<0.05). In contrast, HM patients had significantly increased DC values in the right cerebellum posterior lobe, left precentral gyrus/postcentral gyrus, and right middle cingulate gyrus (P<0.05). However, no relationship was found between the observed mean DC values of the different brain areas and the behavioral performance (P>0.05). CONCLUSION: HM is associated with abnormalities in many brain regions, which may indicate the neural mechanisms of HM. The altered DC values may be used as a useful biomarker for the brain activity changes in HM patients.http://www.ijo.cn/en_publish/2018/11/20181113.pdfhigh myopiadegree centralityfunctional magnetic resonance imagingresting state |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yu-Xiang Hu Jun-Rong He Bo Yang Xin Huang Yu-Ping Li Fu-Qing Zhou Xiao-Xuan Xu Yu-Lin Zhong Jun Wang Xiao-Rong Wu |
spellingShingle |
Yu-Xiang Hu Jun-Rong He Bo Yang Xin Huang Yu-Ping Li Fu-Qing Zhou Xiao-Xuan Xu Yu-Lin Zhong Jun Wang Xiao-Rong Wu Abnormal resting-state functional network centrality in patients with high myopia: evidence from a voxel-wise degree centrality analysis International Journal of Ophthalmology high myopia degree centrality functional magnetic resonance imaging resting state |
author_facet |
Yu-Xiang Hu Jun-Rong He Bo Yang Xin Huang Yu-Ping Li Fu-Qing Zhou Xiao-Xuan Xu Yu-Lin Zhong Jun Wang Xiao-Rong Wu |
author_sort |
Yu-Xiang Hu |
title |
Abnormal resting-state functional network centrality in patients with high myopia: evidence from a voxel-wise degree centrality analysis |
title_short |
Abnormal resting-state functional network centrality in patients with high myopia: evidence from a voxel-wise degree centrality analysis |
title_full |
Abnormal resting-state functional network centrality in patients with high myopia: evidence from a voxel-wise degree centrality analysis |
title_fullStr |
Abnormal resting-state functional network centrality in patients with high myopia: evidence from a voxel-wise degree centrality analysis |
title_full_unstemmed |
Abnormal resting-state functional network centrality in patients with high myopia: evidence from a voxel-wise degree centrality analysis |
title_sort |
abnormal resting-state functional network centrality in patients with high myopia: evidence from a voxel-wise degree centrality analysis |
publisher |
Press of International Journal of Ophthalmology (IJO PRESS) |
series |
International Journal of Ophthalmology |
issn |
2222-3959 2227-4898 |
publishDate |
2018-11-01 |
description |
AIM: To investigate the functional networks underlying the brain-activity changes of patients with high myopia using the voxel-wise degree centrality (DC) method.
METHODS: In total, 38 patients with high myopia (HM) (17 males and 21 females), whose binocular refractive diopter were -6.00 to -7.00 D, and 38 healthy controls (17 males and 21 females), closely matched in age, sex, and education levels, participated in the study. Spontaneous brain activities were evaluated using the voxel-wise DC method. The receiver operating characteristic curve was measured to distinguish patients with HM from healthy controls. Correlation analysis was used to explore the relationship between the observed mean DC values of the different brain areas and the behavioral performance.
RESULTS: Compared with healthy controls, HM patients had significantly decreased DC values in the right inferior frontal gyrus/insula, right middle frontal gyrus, and right supramarginal/inferior parietal lobule (P<0.05). In contrast, HM patients had significantly increased DC values in the right cerebellum posterior lobe, left precentral gyrus/postcentral gyrus, and right middle cingulate gyrus (P<0.05). However, no relationship was found between the observed mean DC values of the different brain areas and the behavioral performance (P>0.05).
CONCLUSION: HM is associated with abnormalities in many brain regions, which may indicate the neural mechanisms of HM. The altered DC values may be used as a useful biomarker for the brain activity changes in HM patients. |
topic |
high myopia degree centrality functional magnetic resonance imaging resting state |
url |
http://www.ijo.cn/en_publish/2018/11/20181113.pdf |
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