Relationship between serum cardiac troponin T level and cardiopulmonary function in stable chronic obstructive pulmonary disease
Kumiko Hattori, Takeo Ishii, Takashi Motegi, Yuji Kusunoki, Akihiko Gemma, Kozui Kida Department of Pulmonary Medicine and Oncology; Respiratory Care Clinic, Nippon Medical School, Tokyo, Japan Background: High-sensitivity cardiac troponin T (hs-cTnT) in serum is a useful marker of acute myocardia...
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doaj-80e34c6b105e4bf492a00bd0f87534512020-11-24T23:36:45ZengDove Medical PressInternational Journal of COPD1178-20052015-02-012015Issue 130932020380Relationship between serum cardiac troponin T level and cardiopulmonary function in stable chronic obstructive pulmonary diseaseHattori KIshii TMotegi TKusunoki YGemma AKida K Kumiko Hattori, Takeo Ishii, Takashi Motegi, Yuji Kusunoki, Akihiko Gemma, Kozui Kida Department of Pulmonary Medicine and Oncology; Respiratory Care Clinic, Nippon Medical School, Tokyo, Japan Background: High-sensitivity cardiac troponin T (hs-cTnT) in serum is a useful marker of acute myocardial injury, yet information is limited in patients with chronic obstructive pulmonary disease. We aimed to explore the association between hs-cTnT levels and cardiac and pulmonary dysfunction in patients with stable chronic obstructive pulmonary disease and at-risk individuals. Methods: We examined community-dwelling adults with/without chronic obstructive pulmonary disease, with a life-long smoking history, current symptoms of dyspnea during exertion, prolonged coughing, and/or sputum. Serum hs-cTnT concentrations were measured, and subjects underwent pulmonary function tests, high-resolution computed tomography of the chest, an echocardiogram, and a 6-minute walking test. Results: Eighty-six stable patients were identified (mean age 65.5 years; predicted forced expiratory volume in 1 second [FEV1% predicted] 75.0%). Their overall mean hs-cTnT level was 0.008 ng/mL. Logarithmically transformed hs-cTnT levels significantly and positively correlated with age, smoking index, serum high-sensitivity C-reactive protein levels, right ventricle systolic pressure, low attenuation area percentage, and brain natriuretic peptide levels (range r=0.231–0.534, P=0.000 to P=0.042). Further, logarithmically transformed hs-cTnT values significantly and negatively correlated with forced vital capacity, FEV1% predicted, diffusion capacity, arterial oxygen tension, and 6-minute walking distance (range r= -0.482 to -0.377, P=0.000 to P=0.002). Multivariate analyses showed that hs-cTnT values varied independently according to the following three parameters: high-sensitivity C-reactive protein levels (B=0.157, ß=0.450, t=3.571, P=0.001), age (B=0.008, ß=0.352, t=2.789, P=0.009), and right ventricular systolic pressure (B=0.008, ß=0.280, t=2.202, P=0.035). Conclusion: Even in patients with stable chronic obstructive pulmonary disease, the serum troponin T concentration was controlled by at least three major factors, ie, systemic inflammation, advancing age, and right cardiac overload. Keywords: chronic obstructive pulmonary disease, troponin T, C-reactive protein, aginghttp://www.dovepress.com/relationship-between-serum-cardiac-troponin-t-level-and-cardiopulmonar-peer-reviewed-article-COPD |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hattori K Ishii T Motegi T Kusunoki Y Gemma A Kida K |
spellingShingle |
Hattori K Ishii T Motegi T Kusunoki Y Gemma A Kida K Relationship between serum cardiac troponin T level and cardiopulmonary function in stable chronic obstructive pulmonary disease International Journal of COPD |
author_facet |
Hattori K Ishii T Motegi T Kusunoki Y Gemma A Kida K |
author_sort |
Hattori K |
title |
Relationship between serum cardiac troponin T level and cardiopulmonary function in stable chronic obstructive pulmonary disease |
title_short |
Relationship between serum cardiac troponin T level and cardiopulmonary function in stable chronic obstructive pulmonary disease |
title_full |
Relationship between serum cardiac troponin T level and cardiopulmonary function in stable chronic obstructive pulmonary disease |
title_fullStr |
Relationship between serum cardiac troponin T level and cardiopulmonary function in stable chronic obstructive pulmonary disease |
title_full_unstemmed |
Relationship between serum cardiac troponin T level and cardiopulmonary function in stable chronic obstructive pulmonary disease |
title_sort |
relationship between serum cardiac troponin t level and cardiopulmonary function in stable chronic obstructive pulmonary disease |
publisher |
Dove Medical Press |
series |
International Journal of COPD |
issn |
1178-2005 |
publishDate |
2015-02-01 |
description |
Kumiko Hattori, Takeo Ishii, Takashi Motegi, Yuji Kusunoki, Akihiko Gemma, Kozui Kida Department of Pulmonary Medicine and Oncology; Respiratory Care Clinic, Nippon Medical School, Tokyo, Japan Background: High-sensitivity cardiac troponin T (hs-cTnT) in serum is a useful marker of acute myocardial injury, yet information is limited in patients with chronic obstructive pulmonary disease. We aimed to explore the association between hs-cTnT levels and cardiac and pulmonary dysfunction in patients with stable chronic obstructive pulmonary disease and at-risk individuals. Methods: We examined community-dwelling adults with/without chronic obstructive pulmonary disease, with a life-long smoking history, current symptoms of dyspnea during exertion, prolonged coughing, and/or sputum. Serum hs-cTnT concentrations were measured, and subjects underwent pulmonary function tests, high-resolution computed tomography of the chest, an echocardiogram, and a 6-minute walking test. Results: Eighty-six stable patients were identified (mean age 65.5 years; predicted forced expiratory volume in 1 second [FEV1% predicted] 75.0%). Their overall mean hs-cTnT level was 0.008 ng/mL. Logarithmically transformed hs-cTnT levels significantly and positively correlated with age, smoking index, serum high-sensitivity C-reactive protein levels, right ventricle systolic pressure, low attenuation area percentage, and brain natriuretic peptide levels (range r=0.231–0.534, P=0.000 to P=0.042). Further, logarithmically transformed hs-cTnT values significantly and negatively correlated with forced vital capacity, FEV1% predicted, diffusion capacity, arterial oxygen tension, and 6-minute walking distance (range r= -0.482 to -0.377, P=0.000 to P=0.002). Multivariate analyses showed that hs-cTnT values varied independently according to the following three parameters: high-sensitivity C-reactive protein levels (B=0.157, ß=0.450, t=3.571, P=0.001), age (B=0.008, ß=0.352, t=2.789, P=0.009), and right ventricular systolic pressure (B=0.008, ß=0.280, t=2.202, P=0.035). Conclusion: Even in patients with stable chronic obstructive pulmonary disease, the serum troponin T concentration was controlled by at least three major factors, ie, systemic inflammation, advancing age, and right cardiac overload. Keywords: chronic obstructive pulmonary disease, troponin T, C-reactive protein, aging |
url |
http://www.dovepress.com/relationship-between-serum-cardiac-troponin-t-level-and-cardiopulmonar-peer-reviewed-article-COPD |
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