Regulatory T cells control toxicity in a humanized model of IL-2 therapy
High dose IL-2 is a viable treatment option for cancer immune therapy, but the underlying mechanism for the accompanying undesirable morbidity is unclear. Here the authors show, using human immune system mouse models, that regulatory T cells and their functions on effector T cells are essential modu...
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Bibliographic Details
Main Authors: |
Yan Li,
Helene Strick-Marchand,
Ai Ing Lim,
Jiazi Ren,
Guillemette Masse-Ranson,
Dan Li,
Gregory Jouvion,
Lars Rogge,
Sophie Lucas,
Bin Li,
James P. Di Santo |
Format: | Article
|
Language: | English |
Published: |
Nature Publishing Group
2017-11-01
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Series: | Nature Communications
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Online Access: | https://doi.org/10.1038/s41467-017-01570-9
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