Regulatory T cells control toxicity in a humanized model of IL-2 therapy
High dose IL-2 is a viable treatment option for cancer immune therapy, but the underlying mechanism for the accompanying undesirable morbidity is unclear. Here the authors show, using human immune system mouse models, that regulatory T cells and their functions on effector T cells are essential modu...
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Online Access: | https://doi.org/10.1038/s41467-017-01570-9 |
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doaj-80f477ac6ea64fb69ea9a165783a23112021-05-11T07:02:29ZengNature Publishing GroupNature Communications2041-17232017-11-018111210.1038/s41467-017-01570-9Regulatory T cells control toxicity in a humanized model of IL-2 therapyYan Li0Helene Strick-Marchand1Ai Ing Lim2Jiazi Ren3Guillemette Masse-Ranson4Dan Li5Gregory Jouvion6Lars Rogge7Sophie Lucas8Bin Li9James P. Di Santo10Institut Pasteur, Innate Immunity Unit, Immunology DepartmentInstitut Pasteur, Innate Immunity Unit, Immunology DepartmentInstitut Pasteur, Innate Immunity Unit, Immunology DepartmentKey Laboratory of Molecular Virology and Immunology, CAS Center for Excellence in Molecular Cell Science, Unit of Molecular Immunology, Institut Pasteur of Shanghai, Shanghai Institutes for Biological Sciences, Chinese Academy of SciencesInstitut Pasteur, Innate Immunity Unit, Immunology DepartmentKey Laboratory of Molecular Virology and Immunology, CAS Center for Excellence in Molecular Cell Science, Unit of Molecular Immunology, Institut Pasteur of Shanghai, Shanghai Institutes for Biological Sciences, Chinese Academy of SciencesInstitut Pasteur, Human Histopathology and Animal Models UnitInstitut Pasteur, Immunoregulation Unit, Immunology Departmentde Duve Institute, Université Catholique de Louvain, and WELBIOKey Laboratory of Molecular Virology and Immunology, CAS Center for Excellence in Molecular Cell Science, Unit of Molecular Immunology, Institut Pasteur of Shanghai, Shanghai Institutes for Biological Sciences, Chinese Academy of SciencesInstitut Pasteur, Innate Immunity Unit, Immunology DepartmentHigh dose IL-2 is a viable treatment option for cancer immune therapy, but the underlying mechanism for the accompanying undesirable morbidity is unclear. Here the authors show, using human immune system mouse models, that regulatory T cells and their functions on effector T cells are essential modulators of the related pathogenesis.https://doi.org/10.1038/s41467-017-01570-9 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yan Li Helene Strick-Marchand Ai Ing Lim Jiazi Ren Guillemette Masse-Ranson Dan Li Gregory Jouvion Lars Rogge Sophie Lucas Bin Li James P. Di Santo |
spellingShingle |
Yan Li Helene Strick-Marchand Ai Ing Lim Jiazi Ren Guillemette Masse-Ranson Dan Li Gregory Jouvion Lars Rogge Sophie Lucas Bin Li James P. Di Santo Regulatory T cells control toxicity in a humanized model of IL-2 therapy Nature Communications |
author_facet |
Yan Li Helene Strick-Marchand Ai Ing Lim Jiazi Ren Guillemette Masse-Ranson Dan Li Gregory Jouvion Lars Rogge Sophie Lucas Bin Li James P. Di Santo |
author_sort |
Yan Li |
title |
Regulatory T cells control toxicity in a humanized model of IL-2 therapy |
title_short |
Regulatory T cells control toxicity in a humanized model of IL-2 therapy |
title_full |
Regulatory T cells control toxicity in a humanized model of IL-2 therapy |
title_fullStr |
Regulatory T cells control toxicity in a humanized model of IL-2 therapy |
title_full_unstemmed |
Regulatory T cells control toxicity in a humanized model of IL-2 therapy |
title_sort |
regulatory t cells control toxicity in a humanized model of il-2 therapy |
publisher |
Nature Publishing Group |
series |
Nature Communications |
issn |
2041-1723 |
publishDate |
2017-11-01 |
description |
High dose IL-2 is a viable treatment option for cancer immune therapy, but the underlying mechanism for the accompanying undesirable morbidity is unclear. Here the authors show, using human immune system mouse models, that regulatory T cells and their functions on effector T cells are essential modulators of the related pathogenesis. |
url |
https://doi.org/10.1038/s41467-017-01570-9 |
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