Peritonitis in children on peritoneal dialysis: 12 years of tertiary center experience
Background and Objective: Peritoneal dialysis (PD) associated peritonitis is the most common cause of morbidity, mortality, and treatment failure in patients undergoing PD. We aimed to identify the incidence, pathogens, antibiotic susceptibility, and the outcome of peritoneal dialysis (PD)-associate...
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doaj-80fb88e00d8046eca9bf2df0bc5060f22021-08-06T04:22:12ZengElsevierInternational Journal of Pediatrics and Adolescent Medicine2352-64672021-12-0184229235Peritonitis in children on peritoneal dialysis: 12 years of tertiary center experienceSaeed M. AlZabli0Mohammed A. Alsuhaibani1Meshail A. BinThunian2Dayel A. Alshahrani3Abdulkarim Al anazi4Sibi Varghese5Vernice Rose6Khawla A. Rahim7Pediatric Nephrology Section, Children Specialized Hospital, King Fahad Medical City, Riyadh, 12231, Saudi Arabia; Corresponding author. Pediatric Nephrologist Pediatric Nephrology Section, Children Hospital, King Fahad Medical City, PO Box: 59046, Dabab Street, 11525, Riyadh, Saudi Arabia.Department of Pediatrics, College of Medicine, Qassim University, Qassim, 51452, Saudi ArabiaGeneral Pediatric Section, Children Specialized Hospital, King Fahad Medical City, Riyadh, 12231, Saudi ArabiaGeneral Pediatric Section, Children Specialized Hospital, King Fahad Medical City, Riyadh, 12231, Saudi ArabiaPediatric Nephrology Section, Children Specialized Hospital, King Fahad Medical City, Riyadh, 12231, Saudi ArabiaPediatric Nephrology Section, Children Specialized Hospital, King Fahad Medical City, Riyadh, 12231, Saudi ArabiaPediatric Nephrology Section, Children Specialized Hospital, King Fahad Medical City, Riyadh, 12231, Saudi ArabiaPediatric Nephrology Section, Children Specialized Hospital, King Fahad Medical City, Riyadh, 12231, Saudi ArabiaBackground and Objective: Peritoneal dialysis (PD) associated peritonitis is the most common cause of morbidity, mortality, and treatment failure in patients undergoing PD. We aimed to identify the incidence, pathogens, antibiotic susceptibility, and the outcome of peritoneal dialysis (PD)-associated peritonitis in children. Methods: Data from medical records of children who underwent PD between 2007 and 2018 in King Fahad Medical City were retrospectively collected. All children aged <14 years undergoing chronic PD were included. The demographic characteristics of patients, peritonitis rates, and clinical outcomes were collected. Results: In total, 131 children [boys, 68 (51.9%)] underwent automated PD for 305 years. The most common age group was 6–12 years (61 patients, 46.6%). A total of 74.0% of patients were new to dialysis; 25.2% were transferred from hemodialysis. Peritonitis incidence was 0.6 episodes/patient-year. Gram-positive and -negative organisms were identified in 50.1% and 22% episodes, respectively, whereas cultures remained negative in 20.5% episodes. Coagulase-negative Staphylococcus was the most common isolated organism (22.1%), followed by methicillin-sensitive S. aureus (11.1%). Peritonitis was resolved in 153 (73.6%) episodes, whereas 52 (25.0%) episodes required removal through the catheter. The multivariate logistic regression analysis found the exit site infection to be a risk factor for catheter removal. Three (1.4%) episodes caused death due to peritonitis complicated by septic shock. Conclusions: Our data showed that the most common organisms causing peritonitis were similar to those reported in the previous international registry. The rate of peritonitis was high, but markedly improved in the past two years.http://www.sciencedirect.com/science/article/pii/S2352646720300776PeritonitisPeritoneal dialysisExit site infectionOutcome |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Saeed M. AlZabli Mohammed A. Alsuhaibani Meshail A. BinThunian Dayel A. Alshahrani Abdulkarim Al anazi Sibi Varghese Vernice Rose Khawla A. Rahim |
spellingShingle |
Saeed M. AlZabli Mohammed A. Alsuhaibani Meshail A. BinThunian Dayel A. Alshahrani Abdulkarim Al anazi Sibi Varghese Vernice Rose Khawla A. Rahim Peritonitis in children on peritoneal dialysis: 12 years of tertiary center experience International Journal of Pediatrics and Adolescent Medicine Peritonitis Peritoneal dialysis Exit site infection Outcome |
author_facet |
Saeed M. AlZabli Mohammed A. Alsuhaibani Meshail A. BinThunian Dayel A. Alshahrani Abdulkarim Al anazi Sibi Varghese Vernice Rose Khawla A. Rahim |
author_sort |
Saeed M. AlZabli |
title |
Peritonitis in children on peritoneal dialysis: 12 years of tertiary center experience |
title_short |
Peritonitis in children on peritoneal dialysis: 12 years of tertiary center experience |
title_full |
Peritonitis in children on peritoneal dialysis: 12 years of tertiary center experience |
title_fullStr |
Peritonitis in children on peritoneal dialysis: 12 years of tertiary center experience |
title_full_unstemmed |
Peritonitis in children on peritoneal dialysis: 12 years of tertiary center experience |
title_sort |
peritonitis in children on peritoneal dialysis: 12 years of tertiary center experience |
publisher |
Elsevier |
series |
International Journal of Pediatrics and Adolescent Medicine |
issn |
2352-6467 |
publishDate |
2021-12-01 |
description |
Background and Objective: Peritoneal dialysis (PD) associated peritonitis is the most common cause of morbidity, mortality, and treatment failure in patients undergoing PD. We aimed to identify the incidence, pathogens, antibiotic susceptibility, and the outcome of peritoneal dialysis (PD)-associated peritonitis in children. Methods: Data from medical records of children who underwent PD between 2007 and 2018 in King Fahad Medical City were retrospectively collected. All children aged <14 years undergoing chronic PD were included. The demographic characteristics of patients, peritonitis rates, and clinical outcomes were collected. Results: In total, 131 children [boys, 68 (51.9%)] underwent automated PD for 305 years. The most common age group was 6–12 years (61 patients, 46.6%). A total of 74.0% of patients were new to dialysis; 25.2% were transferred from hemodialysis. Peritonitis incidence was 0.6 episodes/patient-year. Gram-positive and -negative organisms were identified in 50.1% and 22% episodes, respectively, whereas cultures remained negative in 20.5% episodes. Coagulase-negative Staphylococcus was the most common isolated organism (22.1%), followed by methicillin-sensitive S. aureus (11.1%). Peritonitis was resolved in 153 (73.6%) episodes, whereas 52 (25.0%) episodes required removal through the catheter. The multivariate logistic regression analysis found the exit site infection to be a risk factor for catheter removal. Three (1.4%) episodes caused death due to peritonitis complicated by septic shock. Conclusions: Our data showed that the most common organisms causing peritonitis were similar to those reported in the previous international registry. The rate of peritonitis was high, but markedly improved in the past two years. |
topic |
Peritonitis Peritoneal dialysis Exit site infection Outcome |
url |
http://www.sciencedirect.com/science/article/pii/S2352646720300776 |
work_keys_str_mv |
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