Heterogeneity Matters: Different Regions of Glioblastoma Are Characterized by Distinctive Tumor-Supporting Pathways

Heterogeneity Matters: Different Regions of Glioblastoma Are Characterized by Distinctive Tumor-Supporting Pathways

The glioblastoma microenvironment plays a substantial role in glioma biology. However, few studies have investigated its spatial heterogeneity. Exploiting 5-ALA Fluorescence Guided Surgery (FGS), we were able to distinguish between the tumor core (ALA+), infiltrating area (ALA-PALE) and healthy tiss...

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Bibliographic Details
Main Authors: Ivana Manini, Federica Caponnetto, Emiliano Dalla, Tamara Ius, Giuseppe Maria Della Pepa, Enrico Pegolo, Anna Bartolini, Giuseppe La Rocca, Grazia Menna, Carla Di Loreto, Alessandro Olivi, Miran Skrap, Giovanni Sabatino, Daniela Cesselli
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Cancers
Subjects:
5-aminolevulinc acid
fluorescence guided surgery
glioma associated stem cells
glioblastoma microenvironment
tumor supporting signature
Online Access:https://www.mdpi.com/2072-6694/12/10/2960

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