Cycling hypoxia selects for constitutive HIF stabilization
Abstract Tumors experience temporal and spatial fluctuations in oxygenation. Hypoxia inducible transcription factors (HIF-α) respond to low levels of oxygen and induce re-supply oxygen. HIF-α stabilization is typically facultative, induced by hypoxia and reduced by normoxia. In some cancers, HIF-α s...
Main Authors: | Mariyah Pressley, Jill A. Gallaher, Joel S. Brown, Michal R. Tomaszewski, Punit Borad, Mehdi Damaghi, Robert J. Gillies, Christopher J. Whelan |
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Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2021-03-01
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Series: | Scientific Reports |
Online Access: | https://doi.org/10.1038/s41598-021-85184-8 |
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