Retrotransposon-induced mosaicism in the neural genome
Over the past decade, major discoveries in retrotransposon biology have depicted the neural genome as a dynamic structure during life. In particular, the retrotransposon LINE-1 (L1) has been shown to be transcribed and mobilized in the brain. Retrotransposition in the developing brain, as well as du...
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2018-07-01
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doaj-80fed19c06db4271a4119b11ecf6e8552020-11-25T03:55:47ZengThe Royal SocietyOpen Biology2046-24412018-07-018710.1098/rsob.180074180074Retrotransposon-induced mosaicism in the neural genomeGabriela O. BodeaEleanor G. Z. McKelveyGeoffrey J. FaulknerOver the past decade, major discoveries in retrotransposon biology have depicted the neural genome as a dynamic structure during life. In particular, the retrotransposon LINE-1 (L1) has been shown to be transcribed and mobilized in the brain. Retrotransposition in the developing brain, as well as during adult neurogenesis, provides a milieu in which neural diversity can arise. Dysregulation of retrotransposon activity may also contribute to neurological disease. Here, we review recent reports of retrotransposon activity in the brain, and discuss the temporal nature of retrotransposition and its regulation in neural cells in response to stimuli. We also put forward hypotheses regarding the significance of retrotransposons for brain development and neurological function, and consider the potential implications of this phenomenon for neuropsychiatric and neurodegenerative conditions.https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.180074retrotransposonline-1neuronneurogenesismosaicism |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Gabriela O. Bodea Eleanor G. Z. McKelvey Geoffrey J. Faulkner |
spellingShingle |
Gabriela O. Bodea Eleanor G. Z. McKelvey Geoffrey J. Faulkner Retrotransposon-induced mosaicism in the neural genome Open Biology retrotransposon line-1 neuron neurogenesis mosaicism |
author_facet |
Gabriela O. Bodea Eleanor G. Z. McKelvey Geoffrey J. Faulkner |
author_sort |
Gabriela O. Bodea |
title |
Retrotransposon-induced mosaicism in the neural genome |
title_short |
Retrotransposon-induced mosaicism in the neural genome |
title_full |
Retrotransposon-induced mosaicism in the neural genome |
title_fullStr |
Retrotransposon-induced mosaicism in the neural genome |
title_full_unstemmed |
Retrotransposon-induced mosaicism in the neural genome |
title_sort |
retrotransposon-induced mosaicism in the neural genome |
publisher |
The Royal Society |
series |
Open Biology |
issn |
2046-2441 |
publishDate |
2018-07-01 |
description |
Over the past decade, major discoveries in retrotransposon biology have depicted the neural genome as a dynamic structure during life. In particular, the retrotransposon LINE-1 (L1) has been shown to be transcribed and mobilized in the brain. Retrotransposition in the developing brain, as well as during adult neurogenesis, provides a milieu in which neural diversity can arise. Dysregulation of retrotransposon activity may also contribute to neurological disease. Here, we review recent reports of retrotransposon activity in the brain, and discuss the temporal nature of retrotransposition and its regulation in neural cells in response to stimuli. We also put forward hypotheses regarding the significance of retrotransposons for brain development and neurological function, and consider the potential implications of this phenomenon for neuropsychiatric and neurodegenerative conditions. |
topic |
retrotransposon line-1 neuron neurogenesis mosaicism |
url |
https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.180074 |
work_keys_str_mv |
AT gabrielaobodea retrotransposoninducedmosaicismintheneuralgenome AT eleanorgzmckelvey retrotransposoninducedmosaicismintheneuralgenome AT geoffreyjfaulkner retrotransposoninducedmosaicismintheneuralgenome |
_version_ |
1724468113136680960 |