On the Use of Hair Analysis for Assessing Arsenic Intoxication
Correlations between the concentrations of arsenic in scalp hair and in drinking water as well as in blood and/or urine have been reported. These correlations clearly show exposure–absorption–excretion relationships. In addition, arsenic metabolites such as monomethylarsonic acid...
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doaj-810f3ec396064c6b8f5a61d3967ab6c82020-11-24T23:56:51ZengMDPI AGInternational Journal of Environmental Research and Public Health1660-46012019-03-0116697710.3390/ijerph16060977ijerph16060977On the Use of Hair Analysis for Assessing Arsenic IntoxicationSidney A. Katz0Chemistry Faculty, Rutgers University, Camden, NJ 08102, USACorrelations between the concentrations of arsenic in scalp hair and in drinking water as well as in blood and/or urine have been reported. These correlations clearly show exposure–absorption–excretion relationships. In addition, arsenic metabolites such as monomethylarsonic acid and dimethylarsinic acid have been identified and quantified in these tissues and fluids, leaving little doubt that elevated levels of arsenic in the hair can reflect systemic arsenic intoxication. Consequently, hair analysis has potential merit as a screening procedure for poisoning by arsenic. However, questions regarding the exogenous versus the endogenous deposition of arsenic in the hair, and uncertainties about the normal level of arsenic in the hair remain unresolved. Pending their resolution, the determination of arsenic in hair should remain a screening tool, and clinical signs and symptoms should be employed to complete the diagnosis of arsenic poisoning.http://www.mdpi.com/1660-4601/16/6/977hair analysisarsenic intoxicationarsenicADMEarsenic methylation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sidney A. Katz |
spellingShingle |
Sidney A. Katz On the Use of Hair Analysis for Assessing Arsenic Intoxication International Journal of Environmental Research and Public Health hair analysis arsenic intoxication arsenic ADME arsenic methylation |
author_facet |
Sidney A. Katz |
author_sort |
Sidney A. Katz |
title |
On the Use of Hair Analysis for Assessing Arsenic Intoxication |
title_short |
On the Use of Hair Analysis for Assessing Arsenic Intoxication |
title_full |
On the Use of Hair Analysis for Assessing Arsenic Intoxication |
title_fullStr |
On the Use of Hair Analysis for Assessing Arsenic Intoxication |
title_full_unstemmed |
On the Use of Hair Analysis for Assessing Arsenic Intoxication |
title_sort |
on the use of hair analysis for assessing arsenic intoxication |
publisher |
MDPI AG |
series |
International Journal of Environmental Research and Public Health |
issn |
1660-4601 |
publishDate |
2019-03-01 |
description |
Correlations between the concentrations of arsenic in scalp hair and in drinking water as well as in blood and/or urine have been reported. These correlations clearly show exposure–absorption–excretion relationships. In addition, arsenic metabolites such as monomethylarsonic acid and dimethylarsinic acid have been identified and quantified in these tissues and fluids, leaving little doubt that elevated levels of arsenic in the hair can reflect systemic arsenic intoxication. Consequently, hair analysis has potential merit as a screening procedure for poisoning by arsenic. However, questions regarding the exogenous versus the endogenous deposition of arsenic in the hair, and uncertainties about the normal level of arsenic in the hair remain unresolved. Pending their resolution, the determination of arsenic in hair should remain a screening tool, and clinical signs and symptoms should be employed to complete the diagnosis of arsenic poisoning. |
topic |
hair analysis arsenic intoxication arsenic ADME arsenic methylation |
url |
http://www.mdpi.com/1660-4601/16/6/977 |
work_keys_str_mv |
AT sidneyakatz ontheuseofhairanalysisforassessingarsenicintoxication |
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1725456184207474688 |