Quetiapine-induced Priapism Requiring Frequent Emergency Admissions: A Case Report
Priapism, a rare but well-known adverse reaction of first and second generation anti-psychotics, has been hypothesized to be associated with blockade of alpha 1 receptors. However, genetic abnormalities or heritability of affected cytochrome P450 alleles has not been ruled out as a causal mechanism....
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doaj-81153237cf28478da077a4141ef735392020-11-24T23:16:18ZengElsevierUrology Case Reports2214-44202015-01-01311210.1016/j.eucr.2014.09.003Quetiapine-induced Priapism Requiring Frequent Emergency Admissions: A Case ReportJon C. JacksonChasity L. TorrencePriapism, a rare but well-known adverse reaction of first and second generation anti-psychotics, has been hypothesized to be associated with blockade of alpha 1 receptors. However, genetic abnormalities or heritability of affected cytochrome P450 alleles has not been ruled out as a causal mechanism. A case is presented with three episodes of priapism within 17 days while taking standard FDA (Food and Drug Administration) approved doses of quetiapine. Cytochrome P450 3A4 genotype testing was performed and resulted with normal enzymatic activity. This case further eliminates enzymatic metabolism as a possible cause of priapism, thus strengthening the alpha one receptor blockade hypothesis.http://www.sciencedirect.com/science/article/pii/S2214442014001387PriapismQuetiapineAntipsychotic agents |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jon C. Jackson Chasity L. Torrence |
spellingShingle |
Jon C. Jackson Chasity L. Torrence Quetiapine-induced Priapism Requiring Frequent Emergency Admissions: A Case Report Urology Case Reports Priapism Quetiapine Antipsychotic agents |
author_facet |
Jon C. Jackson Chasity L. Torrence |
author_sort |
Jon C. Jackson |
title |
Quetiapine-induced Priapism Requiring Frequent Emergency Admissions: A Case Report |
title_short |
Quetiapine-induced Priapism Requiring Frequent Emergency Admissions: A Case Report |
title_full |
Quetiapine-induced Priapism Requiring Frequent Emergency Admissions: A Case Report |
title_fullStr |
Quetiapine-induced Priapism Requiring Frequent Emergency Admissions: A Case Report |
title_full_unstemmed |
Quetiapine-induced Priapism Requiring Frequent Emergency Admissions: A Case Report |
title_sort |
quetiapine-induced priapism requiring frequent emergency admissions: a case report |
publisher |
Elsevier |
series |
Urology Case Reports |
issn |
2214-4420 |
publishDate |
2015-01-01 |
description |
Priapism, a rare but well-known adverse reaction of first and second generation anti-psychotics, has been hypothesized to be associated with blockade of alpha 1 receptors. However, genetic abnormalities or heritability of affected cytochrome P450 alleles has not been ruled out as a causal mechanism. A case is presented with three episodes of priapism within 17 days while taking standard FDA (Food and Drug Administration) approved doses of quetiapine. Cytochrome P450 3A4 genotype testing was performed and resulted with normal enzymatic activity. This case further eliminates enzymatic metabolism as a possible cause of priapism, thus strengthening the alpha one receptor blockade hypothesis. |
topic |
Priapism Quetiapine Antipsychotic agents |
url |
http://www.sciencedirect.com/science/article/pii/S2214442014001387 |
work_keys_str_mv |
AT joncjackson quetiapineinducedpriapismrequiringfrequentemergencyadmissionsacasereport AT chasityltorrence quetiapineinducedpriapismrequiringfrequentemergencyadmissionsacasereport |
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