SET8 suppression mediates high glucose-induced vascular endothelial inflammation via the upregulation of PTEN
Diabetes: Protein modulators of vascular inflammation High glucose levels in patients with diabetes trigger vascular inflammation by affecting the expression of key proteins in blood vessel linings. Elevated glucose causes inflammation of the endothelium, a thin layer of cells that lines blood and l...
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doaj-811552601d6c461dbbfdaf7786b94c532021-10-10T11:50:36ZengNature Publishing GroupExperimental and Molecular Medicine1226-36132092-64132020-10-0152101715172910.1038/s12276-020-00509-3SET8 suppression mediates high glucose-induced vascular endothelial inflammation via the upregulation of PTENXuefang Shen0Xiangyuan Chen1Jing Wang2Jing Liu3Zhiyao Wang4Qing Hua5Qichao Wu6Yanguang Su7Huanzhong He8Yuqin Hu9Zhipeng Meng10Wanxia Xiong11Minmin Zhu12Department of Anaesthesiology, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan UniversityDepartment of Anaesthesiology, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan UniversityDepartment of Anaesthesiology, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan UniversityDepartment of Anaesthesiology, Huzhou Central Hospital, Affiliated Central Hospital of HuZhou UniversityDepartment of Anesthesia, Zhongshan Hospital, Fudan UniversityDepartment of Anaesthesiology, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan UniversityDepartment of Anaesthesiology, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan UniversityDepartment of Anaesthesiology, Huzhou Maternal & Child Health Care HospitalDepartment of Anaesthesiology, Huzhou Maternal & Child Health Care HospitalDepartment of Anaesthesiology, Huzhou Maternal & Child Health Care HospitalDepartment of Anaesthesiology, Huzhou Central Hospital, Affiliated Central Hospital of HuZhou UniversityDepartment of Anesthesia, Zhongshan Hospital, Fudan UniversityDepartment of Anaesthesiology, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan UniversityDiabetes: Protein modulators of vascular inflammation High glucose levels in patients with diabetes trigger vascular inflammation by affecting the expression of key proteins in blood vessel linings. Elevated glucose causes inflammation of the endothelium, a thin layer of cells that lines blood and lymph vessels, leading to cardiovascular complications. The phosphatase and tensin homolog protein (PTEN) contributes to endothelial inflammation, but the precise mechanisms are unclear. Xuefang Shen at Fudan University in Shanghai, China, and co-workers demonstrated that elevated glucose increases PTEN expression, with increased levels of the protein found in peripheral blood cells of diabetic patients and aortic tissues of diabetic rats. In further experiments on rats, the researchers found that glucose also suppressed another protein called SET8, which contributed to increased PTEN levels. This suggests that SET8 is involved in PTEN modulation, and that both proteins influence vascular inflammation.https://doi.org/10.1038/s12276-020-00509-3 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Xuefang Shen Xiangyuan Chen Jing Wang Jing Liu Zhiyao Wang Qing Hua Qichao Wu Yanguang Su Huanzhong He Yuqin Hu Zhipeng Meng Wanxia Xiong Minmin Zhu |
spellingShingle |
Xuefang Shen Xiangyuan Chen Jing Wang Jing Liu Zhiyao Wang Qing Hua Qichao Wu Yanguang Su Huanzhong He Yuqin Hu Zhipeng Meng Wanxia Xiong Minmin Zhu SET8 suppression mediates high glucose-induced vascular endothelial inflammation via the upregulation of PTEN Experimental and Molecular Medicine |
author_facet |
Xuefang Shen Xiangyuan Chen Jing Wang Jing Liu Zhiyao Wang Qing Hua Qichao Wu Yanguang Su Huanzhong He Yuqin Hu Zhipeng Meng Wanxia Xiong Minmin Zhu |
author_sort |
Xuefang Shen |
title |
SET8 suppression mediates high glucose-induced vascular endothelial inflammation via the upregulation of PTEN |
title_short |
SET8 suppression mediates high glucose-induced vascular endothelial inflammation via the upregulation of PTEN |
title_full |
SET8 suppression mediates high glucose-induced vascular endothelial inflammation via the upregulation of PTEN |
title_fullStr |
SET8 suppression mediates high glucose-induced vascular endothelial inflammation via the upregulation of PTEN |
title_full_unstemmed |
SET8 suppression mediates high glucose-induced vascular endothelial inflammation via the upregulation of PTEN |
title_sort |
set8 suppression mediates high glucose-induced vascular endothelial inflammation via the upregulation of pten |
publisher |
Nature Publishing Group |
series |
Experimental and Molecular Medicine |
issn |
1226-3613 2092-6413 |
publishDate |
2020-10-01 |
description |
Diabetes: Protein modulators of vascular inflammation High glucose levels in patients with diabetes trigger vascular inflammation by affecting the expression of key proteins in blood vessel linings. Elevated glucose causes inflammation of the endothelium, a thin layer of cells that lines blood and lymph vessels, leading to cardiovascular complications. The phosphatase and tensin homolog protein (PTEN) contributes to endothelial inflammation, but the precise mechanisms are unclear. Xuefang Shen at Fudan University in Shanghai, China, and co-workers demonstrated that elevated glucose increases PTEN expression, with increased levels of the protein found in peripheral blood cells of diabetic patients and aortic tissues of diabetic rats. In further experiments on rats, the researchers found that glucose also suppressed another protein called SET8, which contributed to increased PTEN levels. This suggests that SET8 is involved in PTEN modulation, and that both proteins influence vascular inflammation. |
url |
https://doi.org/10.1038/s12276-020-00509-3 |
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