NT-proBNP in Isolated Diastolic Dysfunction

• Main Authors: Kenan İltümür, Aziz Karabulut, Nizamettin Toprak
• Format: Article
• Language: English
• Published: Dicle University Medical School 2005-01-01
• Series: Dicle Medical Journal
• Subjects: Diastolic Dysfunction; NT-proBNP
• Online Access: http://4181.indexcopernicus.com/fulltxt.php?ICID=888063
• ISSN: 1300-2945; 1308-9889

B-type natriuretic peptide (BNP) is a neurohormone secreted mainly in the cardiac ventricles in response to volume expansion and pressure overload. This peptide, which is diagnostic and prognostic, has been known as a diagnosis toll in distinguishing diagnosis of dispnea.This study aimed the search of the relation between NT-proBNP and diastolic parameters in hypertensive patients whose systolic dysfunction does not develop.This study included 31 healthy individuals (18 M, age; 44 9) and 51 hypertensive patients (29 M, age; 48  9) who had hypertension diagnosis for the first time and were free of cardiovascular disease. NT-proBNP was measured with immünoassey method. Tissue doppler was also measured in addition to the standard echocardiography. In hypertensive group plasma NT-proBNP level was significantly higher than control group. (56 44 and 32  22 p=0,003). Left ventricular ejection fraction (LVEF) was normal in both groups (p>0,05). However, in 23 (45%) of the hipertensive patients diastolic dysfunction (DDF) was found. At the same time left ventricular mass index (LVMI) of the patients had increased. It was found that NT-proBNP was significantly higher in patients with left ventricular DDF than those without (66,1 44,3 ve 38,4  33,2 p=0,003). There was a significant correlation between NT-proBNP and LVMI (r=0,32 p=0,003) and diastolic function parameters (for mitral E/A; r= -0,3 p=0,006 and for mitral tissue E/A ; r= -0,22 p<0,05).As a result, in isolated diastolic dysfunction NT-proBNP level increases. Especially the correlation between NT-proBNP and LVMI and DDF can reflect the increase of afterload in hypertension.