Acute Changes in Mood Induced by Subthalamic Deep Brain Stimulation in Parkinson Disease Are Modulated by Psychiatric Diagnosis
Background: Deep brain stimulation of the subthalamic nucleus (STN DBS) reduces Parkinson disease (PD) motor symptoms but has unexplained, variable effects on mood. Objective: The study tested the hypothesis that pre-existing mood and/or anxiety disorders or increased symptom severity negatively aff...
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Elsevier
2014-09-01
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Series: | Brain Stimulation |
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Online Access: | http://www.sciencedirect.com/science/article/pii/S1935861X1400182X |
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doaj-81274378b2164ec487389d66c303d82d |
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Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sarah A. Eisenstein William B. Dewispelaere Meghan C. Campbell Heather M. Lugar Joel S. Perlmutter Kevin J. Black Tamara Hershey |
spellingShingle |
Sarah A. Eisenstein William B. Dewispelaere Meghan C. Campbell Heather M. Lugar Joel S. Perlmutter Kevin J. Black Tamara Hershey Acute Changes in Mood Induced by Subthalamic Deep Brain Stimulation in Parkinson Disease Are Modulated by Psychiatric Diagnosis Brain Stimulation Parkinson disease Subthalamic nucleus Deep brain stimulation Mood Mood disorder Anxiety disorder |
author_facet |
Sarah A. Eisenstein William B. Dewispelaere Meghan C. Campbell Heather M. Lugar Joel S. Perlmutter Kevin J. Black Tamara Hershey |
author_sort |
Sarah A. Eisenstein |
title |
Acute Changes in Mood Induced by Subthalamic Deep Brain Stimulation in Parkinson Disease Are Modulated by Psychiatric Diagnosis |
title_short |
Acute Changes in Mood Induced by Subthalamic Deep Brain Stimulation in Parkinson Disease Are Modulated by Psychiatric Diagnosis |
title_full |
Acute Changes in Mood Induced by Subthalamic Deep Brain Stimulation in Parkinson Disease Are Modulated by Psychiatric Diagnosis |
title_fullStr |
Acute Changes in Mood Induced by Subthalamic Deep Brain Stimulation in Parkinson Disease Are Modulated by Psychiatric Diagnosis |
title_full_unstemmed |
Acute Changes in Mood Induced by Subthalamic Deep Brain Stimulation in Parkinson Disease Are Modulated by Psychiatric Diagnosis |
title_sort |
acute changes in mood induced by subthalamic deep brain stimulation in parkinson disease are modulated by psychiatric diagnosis |
publisher |
Elsevier |
series |
Brain Stimulation |
issn |
1935-861X |
publishDate |
2014-09-01 |
description |
Background: Deep brain stimulation of the subthalamic nucleus (STN DBS) reduces Parkinson disease (PD) motor symptoms but has unexplained, variable effects on mood. Objective: The study tested the hypothesis that pre-existing mood and/or anxiety disorders or increased symptom severity negatively affects mood response to STN DBS. Methods: Thirty-eight PD participants with bilateral STN DBS and on PD medications were interviewed with Structured Clinical Interview for DSM-IV-TR Axis I Disorders (SCID) and completed Beck Depression Inventory (BDI) and Spielberger State Anxiety Inventory (SSAI) self-reports. Subsequently, during OFF and optimal ON (clinical settings) STN DBS conditions and while off PD medications, motor function was assessed with the United Parkinson Disease Rating Scale (UPDRS, part III), and participants rated their mood with Visual Analogue Scales (VAS), and again completed SSAI. VAS mood variables included anxiety, apathy, valence and emotional arousal. Results: STN DBS improved UPDRS scores and mood. Unexpectedly, PD participants diagnosed with current anxiety or mood disorders experienced greater STN DBS-induced improvement in mood than those diagnosed with remitted disorders or who were deemed as having never met threshold criteria for diagnosis. BDI and SSAI scores did not modulate mood response to STN DBS, indicating that clinical categorical diagnosis better differentiates mood response to STN DBS than self-rated symptom severity. SCID diagnosis, BDI and SSAI scores did not modulate motor response to STN DBS. Conclusions: PD participants diagnosed with current mood or anxiety disorders are more sensitive to STN DBS-induced effects on mood, possibly indicating altered basal ganglia circuitry in this group. |
topic |
Parkinson disease Subthalamic nucleus Deep brain stimulation Mood Mood disorder Anxiety disorder |
url |
http://www.sciencedirect.com/science/article/pii/S1935861X1400182X |
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doaj-81274378b2164ec487389d66c303d82d2021-03-18T04:37:54ZengElsevierBrain Stimulation1935-861X2014-09-0175701708Acute Changes in Mood Induced by Subthalamic Deep Brain Stimulation in Parkinson Disease Are Modulated by Psychiatric DiagnosisSarah A. Eisenstein0William B. Dewispelaere1Meghan C. Campbell2Heather M. Lugar3Joel S. Perlmutter4Kevin J. Black5Tamara Hershey6Department of Psychiatry, Washington University in St. Louis, St. Louis, MO, USACollege of Arts and Sciences, Washington University in St. Louis, St. Louis, MO, USADepartment of Neurology, Washington University in St. Louis, St. Louis, MO, USA; Department of Radiology, Washington University in St. Louis, St. Louis, MO, USADepartment of Psychiatry, Washington University in St. Louis, St. Louis, MO, USADepartment of Neurology, Washington University in St. Louis, St. Louis, MO, USA; Department of Radiology, Washington University in St. Louis, St. Louis, MO, USA; Department of Anatomy & Neurobiology, Washington University in St. Louis, St. Louis, MO, USA; Division of Biology and Biomedical Sciences, Washington University in St. Louis, St. Louis, MO, USA; Programs in Physical Therapy and Occupational Therapy, Washington University in St. Louis, St. Louis, MO, USADepartment of Psychiatry, Washington University in St. Louis, St. Louis, MO, USA; Department of Neurology, Washington University in St. Louis, St. Louis, MO, USA; Department of Radiology, Washington University in St. Louis, St. Louis, MO, USA; Department of Anatomy & Neurobiology, Washington University in St. Louis, St. Louis, MO, USA; Division of Biology and Biomedical Sciences, Washington University in St. Louis, St. Louis, MO, USADepartment of Psychiatry, Washington University in St. Louis, St. Louis, MO, USA; Department of Neurology, Washington University in St. Louis, St. Louis, MO, USA; Department of Radiology, Washington University in St. Louis, St. Louis, MO, USA; Division of Biology and Biomedical Sciences, Washington University in St. Louis, St. Louis, MO, USA; Corresponding author. Department of Psychiatry, Washington University in St. Louis, Campus Box 8134, 660 S. Euclid Avenue, St. Louis, MO 63110-1093, USA. Tel.: +1 314 362 5593.Background: Deep brain stimulation of the subthalamic nucleus (STN DBS) reduces Parkinson disease (PD) motor symptoms but has unexplained, variable effects on mood. Objective: The study tested the hypothesis that pre-existing mood and/or anxiety disorders or increased symptom severity negatively affects mood response to STN DBS. Methods: Thirty-eight PD participants with bilateral STN DBS and on PD medications were interviewed with Structured Clinical Interview for DSM-IV-TR Axis I Disorders (SCID) and completed Beck Depression Inventory (BDI) and Spielberger State Anxiety Inventory (SSAI) self-reports. Subsequently, during OFF and optimal ON (clinical settings) STN DBS conditions and while off PD medications, motor function was assessed with the United Parkinson Disease Rating Scale (UPDRS, part III), and participants rated their mood with Visual Analogue Scales (VAS), and again completed SSAI. VAS mood variables included anxiety, apathy, valence and emotional arousal. Results: STN DBS improved UPDRS scores and mood. Unexpectedly, PD participants diagnosed with current anxiety or mood disorders experienced greater STN DBS-induced improvement in mood than those diagnosed with remitted disorders or who were deemed as having never met threshold criteria for diagnosis. BDI and SSAI scores did not modulate mood response to STN DBS, indicating that clinical categorical diagnosis better differentiates mood response to STN DBS than self-rated symptom severity. SCID diagnosis, BDI and SSAI scores did not modulate motor response to STN DBS. Conclusions: PD participants diagnosed with current mood or anxiety disorders are more sensitive to STN DBS-induced effects on mood, possibly indicating altered basal ganglia circuitry in this group.http://www.sciencedirect.com/science/article/pii/S1935861X1400182XParkinson diseaseSubthalamic nucleusDeep brain stimulationMoodMood disorderAnxiety disorder |