Structural characterization of two metastable ATP-bound states of P-glycoprotein.
ATP Binding Cassette (ABC) transporters couple the binding and hydrolysis of ATP to the transport of substrate molecules across the membrane. The mechanism by which ATP binding and/or hydrolysis drives the conformational changes associated with substrate transport has not yet been characterized full...
Main Authors: | Megan L O'Mara, Alan E Mark |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2014-01-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3954865?pdf=render |
Similar Items
-
Association of Protein Disulfide Isomerase and ATP Synthase β Subunit with Membrane-Bound P-Glycoprotein
by: Zhang, Yifeng
Published: (2014) -
The reliability of molecular dynamics simulations of the multidrug transporter P-glycoprotein in a membrane environment.
by: Karmen Condic-Jurkic, et al.
Published: (2018-01-01) -
Metastability for scalar conservation laws in a bounded domain
by: Mascia Corrado, et al.
Published: (2014-09-01) -
Dynamics, Conformational Transition and Drug Interactions of P-glycoprotein upon ATP Binding
by: Hui-Hsuan Tu, et al.
Published: (2005) -
The Two-Step Clustering Approach for Metastable States Learning
by: Hangjin Jiang, et al.
Published: (2021-06-01)