The microRNA-127-3p directly targeting Vamp2 in C2C12 myoblasts

• Main Authors: Jie Li, Gaofu Wang, Jing Jiang, Lin Fu, Peng Zhou, Hangxing Ren
• Format: Article
• Language: English
• Published: Taylor & Francis Group 2018-09-01
• Series: Animal Cells and Systems
• Subjects: Myogenesis; miR-127-3p; Vamp2; C2C12
• Online Access: http://dx.doi.org/10.1080/19768354.2018.1512520
• ISSN: 1976-8354; 2151-2485

MicroRNAs (miRNAs) have been reported that can regulate skeletal muscle growth and development. Previously, we demonstrated that miR-127-3p were differently expressed in skeletal muscle and muscle cells. However, the molecular mechanism of miR-127-3p regulation of skeletal myogenesis are not well elucidated. In this study, we transfected miR-127-3p into C2C12 cells, and found miR-127-3p induces myogenesis by targeting Vamp2. Moreover, the regulatory mechanism of Vamp2 in myoblasts proliferation and differentiation was further confirmed. In conclusion, our data providedevidences that miR-127-3p reciprocally regulated myoblasts proliferation and differentiation through directly targeting Vamp2.