Poly-ion complex (PIC) formation of heparin and polyamines: PIC with tetrakis (3-aminopropyl) ammonium allows sustained release of heparin
Physical mixtures of cationic polymers and heparin have been developed to overcome the limitations of unfractionated heparin. In this study, we found that heparin associates with natural polyamines in water, resulting in the generation of a poly-ion complex (PIC). PIC formation (or stability) was in...
Main Authors: | Daichi Ito, Dan Ge, Noriyuki Kogure, Hitomi Manaka, Yusuke Terui, Hiromitsu Takayama, Robert J. Linhardt, Toshihiko Toida, Kyohei Higashi |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2020-10-01
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Series: | Heliyon |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844020320119 |
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