The role of telomere-binding modulators in pluripotent stem cells
Abstract Pluripotent stem cells (PSCs) such as embryonic stem cells (ESCs), ESCs derived by somatic cell nuclear transfer (ntESCs), and induced pluripotent stem cells (iPSCs) have unlimited capacity for self-renewal and pluripotency and can give rise to all types of somatic cells. In order to mainta...
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doaj-813877c83e004438b37ac47cf9940bc42020-11-25T03:05:51ZengSpringerOpenProtein & Cell1674-800X1674-80182019-07-01111607010.1007/s13238-019-0651-yThe role of telomere-binding modulators in pluripotent stem cellsFeng Li0Yuanlong Ge1Dan Liu2Zhou Songyang3State Key Laboratory of Oncology in South China, Cancer Center, Collaborative Innovation Center for Cancer Medicine, and Key Laboratory of Gene Engineering of the Ministry of Education, School of Life Sciences, Sun Yat-sen UniversityState Key Laboratory of Oncology in South China, Cancer Center, Collaborative Innovation Center for Cancer Medicine, and Key Laboratory of Gene Engineering of the Ministry of Education, School of Life Sciences, Sun Yat-sen UniversityVerna and Marrs Department of Biochemistry and Molecular Biology, Baylor College of MedicineState Key Laboratory of Oncology in South China, Cancer Center, Collaborative Innovation Center for Cancer Medicine, and Key Laboratory of Gene Engineering of the Ministry of Education, School of Life Sciences, Sun Yat-sen UniversityAbstract Pluripotent stem cells (PSCs) such as embryonic stem cells (ESCs), ESCs derived by somatic cell nuclear transfer (ntESCs), and induced pluripotent stem cells (iPSCs) have unlimited capacity for self-renewal and pluripotency and can give rise to all types of somatic cells. In order to maintain their self-renewal and pluripotency, PSCs need to preserve their telomere length and homeostasis. In recent years, increasing studies have shown that telomere reprogramming is essential for stem cell pluripotency maintenance and its induced pluripotency process. Telomere-associated proteins are not only required for telomere maintenance in both stem cells, their extra-telomeric functions have also been found to be critical as well. Here, we will discuss how telomeres and telomere-associated factors participate and regulate the maintenance of stem cell pluripotency.http://link.springer.com/article/10.1007/s13238-019-0651-ytelomerepluripotent stem cellstelomeraseALTshelterin/telosome complex |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Feng Li Yuanlong Ge Dan Liu Zhou Songyang |
spellingShingle |
Feng Li Yuanlong Ge Dan Liu Zhou Songyang The role of telomere-binding modulators in pluripotent stem cells Protein & Cell telomere pluripotent stem cells telomerase ALT shelterin/telosome complex |
author_facet |
Feng Li Yuanlong Ge Dan Liu Zhou Songyang |
author_sort |
Feng Li |
title |
The role of telomere-binding modulators in pluripotent stem cells |
title_short |
The role of telomere-binding modulators in pluripotent stem cells |
title_full |
The role of telomere-binding modulators in pluripotent stem cells |
title_fullStr |
The role of telomere-binding modulators in pluripotent stem cells |
title_full_unstemmed |
The role of telomere-binding modulators in pluripotent stem cells |
title_sort |
role of telomere-binding modulators in pluripotent stem cells |
publisher |
SpringerOpen |
series |
Protein & Cell |
issn |
1674-800X 1674-8018 |
publishDate |
2019-07-01 |
description |
Abstract Pluripotent stem cells (PSCs) such as embryonic stem cells (ESCs), ESCs derived by somatic cell nuclear transfer (ntESCs), and induced pluripotent stem cells (iPSCs) have unlimited capacity for self-renewal and pluripotency and can give rise to all types of somatic cells. In order to maintain their self-renewal and pluripotency, PSCs need to preserve their telomere length and homeostasis. In recent years, increasing studies have shown that telomere reprogramming is essential for stem cell pluripotency maintenance and its induced pluripotency process. Telomere-associated proteins are not only required for telomere maintenance in both stem cells, their extra-telomeric functions have also been found to be critical as well. Here, we will discuss how telomeres and telomere-associated factors participate and regulate the maintenance of stem cell pluripotency. |
topic |
telomere pluripotent stem cells telomerase ALT shelterin/telosome complex |
url |
http://link.springer.com/article/10.1007/s13238-019-0651-y |
work_keys_str_mv |
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