Cognitive and Neuropsychiatric Symptom Differences in Early Stages of Alzheimer’s Disease: Kuopio ALSOVA Study
Background/Aim: Alzheimer’s disease (AD) causes impairment in memory and other cognitive functions as well as neuropsychiatric symptoms and limitations in the activities of daily living (ADL). The aim of this study was to examine whether demographic variables, dementia severity, ADL and neuropsychia...
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2012-05-01
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Series: | Dementia and Geriatric Cognitive Disorders Extra |
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Online Access: | http://www.karger.com/Article/FullText/338231 |
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doaj-81389980acee404880c460f4a5b404a22020-11-25T03:18:47ZengKarger PublishersDementia and Geriatric Cognitive Disorders Extra1664-54642012-05-012120921810.1159/000338231338231Cognitive and Neuropsychiatric Symptom Differences in Early Stages of Alzheimer’s Disease: Kuopio ALSOVA StudyIlona HallikainenAnne M. KoivistoTeemu PaajanenAsta HiltunenPertti KarppiMatti VanhanenTarja VälimäkiSanna-Kaisa HerukkaHilkka SoininenTuomo HänninenBackground/Aim: Alzheimer’s disease (AD) causes impairment in memory and other cognitive functions as well as neuropsychiatric symptoms and limitations in the activities of daily living (ADL). The aim of this study was to examine whether demographic variables, dementia severity, ADL and neuropsychiatric symptoms are associated with cognition in very mild or mild AD. Methods: We analyzed the baseline data of 236 patients with very mild or mild AD participating in a prospective AD follow-up study (ALSOVA). The Consortium to Establish a Registry for Alzheimer’s Disease neuropsychological battery total score was used in the evaluation of the global cognitive performance. Results: Cognition was associated with dementia severity and ADL but not with neuropsychiatric symptoms. ADL functions were associated with both cognitive performance and neuropsychiatric symptoms. Conclusion: Even patients with very mild or mild AD may exhibit neuropsychiatric symptoms not related to cognitive impairment. The results of this study emphasize the importance of taking a multidimensional approach to the diagnostic and prognostic evaluation of AD patients already in the early stages of the disease.http://www.karger.com/Article/FullText/338231Alzheimer’s diseaseDementiaMemoryNeuropsychiatric symptomsNeuropsychological tests |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ilona Hallikainen Anne M. Koivisto Teemu Paajanen Asta Hiltunen Pertti Karppi Matti Vanhanen Tarja Välimäki Sanna-Kaisa Herukka Hilkka Soininen Tuomo Hänninen |
spellingShingle |
Ilona Hallikainen Anne M. Koivisto Teemu Paajanen Asta Hiltunen Pertti Karppi Matti Vanhanen Tarja Välimäki Sanna-Kaisa Herukka Hilkka Soininen Tuomo Hänninen Cognitive and Neuropsychiatric Symptom Differences in Early Stages of Alzheimer’s Disease: Kuopio ALSOVA Study Dementia and Geriatric Cognitive Disorders Extra Alzheimer’s disease Dementia Memory Neuropsychiatric symptoms Neuropsychological tests |
author_facet |
Ilona Hallikainen Anne M. Koivisto Teemu Paajanen Asta Hiltunen Pertti Karppi Matti Vanhanen Tarja Välimäki Sanna-Kaisa Herukka Hilkka Soininen Tuomo Hänninen |
author_sort |
Ilona Hallikainen |
title |
Cognitive and Neuropsychiatric Symptom Differences in Early Stages of Alzheimer’s Disease: Kuopio ALSOVA Study |
title_short |
Cognitive and Neuropsychiatric Symptom Differences in Early Stages of Alzheimer’s Disease: Kuopio ALSOVA Study |
title_full |
Cognitive and Neuropsychiatric Symptom Differences in Early Stages of Alzheimer’s Disease: Kuopio ALSOVA Study |
title_fullStr |
Cognitive and Neuropsychiatric Symptom Differences in Early Stages of Alzheimer’s Disease: Kuopio ALSOVA Study |
title_full_unstemmed |
Cognitive and Neuropsychiatric Symptom Differences in Early Stages of Alzheimer’s Disease: Kuopio ALSOVA Study |
title_sort |
cognitive and neuropsychiatric symptom differences in early stages of alzheimer’s disease: kuopio alsova study |
publisher |
Karger Publishers |
series |
Dementia and Geriatric Cognitive Disorders Extra |
issn |
1664-5464 |
publishDate |
2012-05-01 |
description |
Background/Aim: Alzheimer’s disease (AD) causes impairment in memory and other cognitive functions as well as neuropsychiatric symptoms and limitations in the activities of daily living (ADL). The aim of this study was to examine whether demographic variables, dementia severity, ADL and neuropsychiatric symptoms are associated with cognition in very mild or mild AD. Methods: We analyzed the baseline data of 236 patients with very mild or mild AD participating in a prospective AD follow-up study (ALSOVA). The Consortium to Establish a Registry for Alzheimer’s Disease neuropsychological battery total score was used in the evaluation of the global cognitive performance. Results: Cognition was associated with dementia severity and ADL but not with neuropsychiatric symptoms. ADL functions were associated with both cognitive performance and neuropsychiatric symptoms. Conclusion: Even patients with very mild or mild AD may exhibit neuropsychiatric symptoms not related to cognitive impairment. The results of this study emphasize the importance of taking a multidimensional approach to the diagnostic and prognostic evaluation of AD patients already in the early stages of the disease. |
topic |
Alzheimer’s disease Dementia Memory Neuropsychiatric symptoms Neuropsychological tests |
url |
http://www.karger.com/Article/FullText/338231 |
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