Lipidomic Profiles of the Heart and Circulation in Response to Exercise versus Cardiac Pathology: A Resource of Potential Biomarkers and Drug Targets
Summary: Exercise-induced heart growth provides protection against cardiovascular disease, whereas disease-induced heart growth leads to heart failure. These distinct forms of growth are associated with different molecular profiles (e.g., mRNAs, non-coding RNAs, and proteins), and targeting differen...
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doaj-8141d5ca40064210923f96be04c475cf2020-11-24T21:54:59ZengElsevierCell Reports2211-12472018-09-01241027572772Lipidomic Profiles of the Heart and Circulation in Response to Exercise versus Cardiac Pathology: A Resource of Potential Biomarkers and Drug TargetsYow Keat Tham0Bianca C. Bernardo1Kevin Huynh2Jenny Y.Y. Ooi3Xiao Ming Gao4Helen Kiriazis5Corey Giles6Peter J. Meikle7Julie R. McMullen8Baker Heart and Diabetes Institute, Melbourne, VIC 3004, Australia; Department of Medicine, Monash University, Clayton, VIC 3800, AustraliaBaker Heart and Diabetes Institute, Melbourne, VIC 3004, Australia; Department of Diabetes, Central Clinical School, Monash University, Clayton, VIC 3800, Australia; Department of Paediatrics, University of Melbourne, Parkville, VIC 3052, AustraliaBaker Heart and Diabetes Institute, Melbourne, VIC 3004, Australia; Department of Medicine, Monash University, Clayton, VIC 3800, AustraliaBaker Heart and Diabetes Institute, Melbourne, VIC 3004, Australia; Department of Diabetes, Central Clinical School, Monash University, Clayton, VIC 3800, AustraliaBaker Heart and Diabetes Institute, Melbourne, VIC 3004, AustraliaBaker Heart and Diabetes Institute, Melbourne, VIC 3004, AustraliaBaker Heart and Diabetes Institute, Melbourne, VIC 3004, AustraliaBaker Heart and Diabetes Institute, Melbourne, VIC 3004, Australia; Department of Medicine, Monash University, Clayton, VIC 3800, Australia; Corresponding authorBaker Heart and Diabetes Institute, Melbourne, VIC 3004, Australia; Department of Medicine, Monash University, Clayton, VIC 3800, Australia; Department of Diabetes, Central Clinical School, Monash University, Clayton, VIC 3800, Australia; Department of Physiology, Monash University, Clayton, VIC 3800, Australia; Corresponding authorSummary: Exercise-induced heart growth provides protection against cardiovascular disease, whereas disease-induced heart growth leads to heart failure. These distinct forms of growth are associated with different molecular profiles (e.g., mRNAs, non-coding RNAs, and proteins), and targeting differentially regulated genes has therapeutic potential for heart failure. The effects of exercise on the cardiac and circulating lipidomes in comparison to disease are unclear. Lipidomic profiling was performed on hearts and plasma of mice subjected to swim endurance training or a cardiac disease model (moderate or severe pressure overload). Several sphingolipid species and phospholipids containing omega-3/6 fatty acids were distinctly altered in heart and/or plasma with exercise versus pressure overload. A subset of lipids was validated in an independent mouse model with heart failure and atrial fibrillation. This study highlights the adaptations that occur to lipid profiles in response to endurance training versus pathology and provides a resource to investigate potential therapeutic targets and biomarkers. : Tham et al. utilized a HPLC-ESI/MS/MS targeted lipidomics approach to show distinct remodeling of the cardiac and plasma lipidomes in response to exercise in comparison to heart disease stimuli. Differentially altered lipids were validated in a model with heart failure and atrial fibrillation and represent potential biomarkers and drug targets. Keywords: lipids, heart, exercise, physiological hypertrophy, pathological hypertrophy, atrial fibrillation, phospholipids, sphingolipids, biomarkers, treatmenthttp://www.sciencedirect.com/science/article/pii/S2211124718312713 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yow Keat Tham Bianca C. Bernardo Kevin Huynh Jenny Y.Y. Ooi Xiao Ming Gao Helen Kiriazis Corey Giles Peter J. Meikle Julie R. McMullen |
spellingShingle |
Yow Keat Tham Bianca C. Bernardo Kevin Huynh Jenny Y.Y. Ooi Xiao Ming Gao Helen Kiriazis Corey Giles Peter J. Meikle Julie R. McMullen Lipidomic Profiles of the Heart and Circulation in Response to Exercise versus Cardiac Pathology: A Resource of Potential Biomarkers and Drug Targets Cell Reports |
author_facet |
Yow Keat Tham Bianca C. Bernardo Kevin Huynh Jenny Y.Y. Ooi Xiao Ming Gao Helen Kiriazis Corey Giles Peter J. Meikle Julie R. McMullen |
author_sort |
Yow Keat Tham |
title |
Lipidomic Profiles of the Heart and Circulation in Response to Exercise versus Cardiac Pathology: A Resource of Potential Biomarkers and Drug Targets |
title_short |
Lipidomic Profiles of the Heart and Circulation in Response to Exercise versus Cardiac Pathology: A Resource of Potential Biomarkers and Drug Targets |
title_full |
Lipidomic Profiles of the Heart and Circulation in Response to Exercise versus Cardiac Pathology: A Resource of Potential Biomarkers and Drug Targets |
title_fullStr |
Lipidomic Profiles of the Heart and Circulation in Response to Exercise versus Cardiac Pathology: A Resource of Potential Biomarkers and Drug Targets |
title_full_unstemmed |
Lipidomic Profiles of the Heart and Circulation in Response to Exercise versus Cardiac Pathology: A Resource of Potential Biomarkers and Drug Targets |
title_sort |
lipidomic profiles of the heart and circulation in response to exercise versus cardiac pathology: a resource of potential biomarkers and drug targets |
publisher |
Elsevier |
series |
Cell Reports |
issn |
2211-1247 |
publishDate |
2018-09-01 |
description |
Summary: Exercise-induced heart growth provides protection against cardiovascular disease, whereas disease-induced heart growth leads to heart failure. These distinct forms of growth are associated with different molecular profiles (e.g., mRNAs, non-coding RNAs, and proteins), and targeting differentially regulated genes has therapeutic potential for heart failure. The effects of exercise on the cardiac and circulating lipidomes in comparison to disease are unclear. Lipidomic profiling was performed on hearts and plasma of mice subjected to swim endurance training or a cardiac disease model (moderate or severe pressure overload). Several sphingolipid species and phospholipids containing omega-3/6 fatty acids were distinctly altered in heart and/or plasma with exercise versus pressure overload. A subset of lipids was validated in an independent mouse model with heart failure and atrial fibrillation. This study highlights the adaptations that occur to lipid profiles in response to endurance training versus pathology and provides a resource to investigate potential therapeutic targets and biomarkers. : Tham et al. utilized a HPLC-ESI/MS/MS targeted lipidomics approach to show distinct remodeling of the cardiac and plasma lipidomes in response to exercise in comparison to heart disease stimuli. Differentially altered lipids were validated in a model with heart failure and atrial fibrillation and represent potential biomarkers and drug targets. Keywords: lipids, heart, exercise, physiological hypertrophy, pathological hypertrophy, atrial fibrillation, phospholipids, sphingolipids, biomarkers, treatment |
url |
http://www.sciencedirect.com/science/article/pii/S2211124718312713 |
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