Effect of Garlic (Allium sativum L.) Bulb Skin Extract on Urea and Creatinine Levels in Alloxan-Induced Hyperglycemia Wistar Rat
Background: Garlic bulb skin extract contains flavonoid, alkaloid, saponin, quinone and polyphenol. Garlic bulb skin is a waste of garlic bulb which has not been optimally used so far for medical purpose. Objective: to discover the influence of garlic (Allium sativum L.) bulb skin extract on urea an...
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Universitas Sultan Agung Semarang
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doaj-814fab4db969465fb2dfd44d876ad31d2020-11-24T21:00:34ZengUniversitas Sultan Agung SemarangSains Medika2085-15452339-093X2016-06-0171252910.26532/sainsmed.v7i1.11681034Effect of Garlic (Allium sativum L.) Bulb Skin Extract on Urea and Creatinine Levels in Alloxan-Induced Hyperglycemia Wistar RatAbdur Rosyid0Rina Wijayanti1Nuzlil Laily Nur Azizah2Pharmacy Department, Medical Faculty, Sultan Agung Islamic University Semarang Jl. Kaligawe KM 4 Semarang 50012 Telp (+6224) 6583584 Fax (+6224) 6594366 Semarang *Corresponding author email : rosyidabdur46@gmail.comPharmacy Department, Medical Faculty, Sultan Agung Islamic University Semarang Jl. Kaligawe KM 4 Semarang 50012 Telp (+6224) 6583584 Fax (+6224) 6594366 SemarangPharmacy Department, Medical Faculty, Sultan Agung Islamic University Semarang Jl. Kaligawe KM 4 Semarang 50012 Telp (+6224) 6583584 Fax (+6224) 6594366 SemarangBackground: Garlic bulb skin extract contains flavonoid, alkaloid, saponin, quinone and polyphenol. Garlic bulb skin is a waste of garlic bulb which has not been optimally used so far for medical purpose. Objective: to discover the influence of garlic (Allium sativum L.) bulb skin extract on urea and creatinine levels in alloxan-induced hyperglycemia wistar rat. Methods: Experimental research using post-test control group design and its statistic analysis using Kruskal Wallis followed with Mann Witney test. The hyperglychemia rat is made by inducing alloxan at a single dose of 160 mg/kg bodyweight (BW) intraperitoneally. The garlic bulb skin extract doses used are 200mg/200gBW, 400mg/200gBW, and 800mg/200gBW for 14 days. The blood is sampled through vena orbitalis which is tested for its urea and creatinine levels. Results: The urea test in hyperglychemia rat administered with 200mg/200gBB garlic bulb skin extract (average urea level 88.87 mg/dL) has no differencce from the negative group (p>0.05), while the 400mg/200gBB and 800mg/200gBB doses (average urea levels 41.86 mg/dL and 41.96 mg/dL) show significant difference (p<0.05). The creatinine test shows significant influence (p<0.05) in extract dose of 400mg/200gBB (average creatinine level 1.16 mg/dL). Conclusion: it can be concluded that garlic bulb skin extract may have some influence in reducing urea level at 400mg/200gBB and 800mg/200gBB doses and creatinine level at 400mg/200gBB dose.http://jurnal.unissula.ac.id/index.php/sainsmedika/article/view/1168Garlic bulb skinhyperglycemiaurea and creatinine levels. |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Abdur Rosyid Rina Wijayanti Nuzlil Laily Nur Azizah |
spellingShingle |
Abdur Rosyid Rina Wijayanti Nuzlil Laily Nur Azizah Effect of Garlic (Allium sativum L.) Bulb Skin Extract on Urea and Creatinine Levels in Alloxan-Induced Hyperglycemia Wistar Rat Sains Medika Garlic bulb skin hyperglycemia urea and creatinine levels. |
author_facet |
Abdur Rosyid Rina Wijayanti Nuzlil Laily Nur Azizah |
author_sort |
Abdur Rosyid |
title |
Effect of Garlic (Allium sativum L.) Bulb Skin Extract on Urea and Creatinine Levels in Alloxan-Induced Hyperglycemia Wistar Rat |
title_short |
Effect of Garlic (Allium sativum L.) Bulb Skin Extract on Urea and Creatinine Levels in Alloxan-Induced Hyperglycemia Wistar Rat |
title_full |
Effect of Garlic (Allium sativum L.) Bulb Skin Extract on Urea and Creatinine Levels in Alloxan-Induced Hyperglycemia Wistar Rat |
title_fullStr |
Effect of Garlic (Allium sativum L.) Bulb Skin Extract on Urea and Creatinine Levels in Alloxan-Induced Hyperglycemia Wistar Rat |
title_full_unstemmed |
Effect of Garlic (Allium sativum L.) Bulb Skin Extract on Urea and Creatinine Levels in Alloxan-Induced Hyperglycemia Wistar Rat |
title_sort |
effect of garlic (allium sativum l.) bulb skin extract on urea and creatinine levels in alloxan-induced hyperglycemia wistar rat |
publisher |
Universitas Sultan Agung Semarang |
series |
Sains Medika |
issn |
2085-1545 2339-093X |
publishDate |
2016-06-01 |
description |
Background: Garlic bulb skin extract contains flavonoid, alkaloid, saponin, quinone and polyphenol. Garlic bulb skin is a waste of garlic bulb which has not been optimally used so far for medical purpose. Objective: to discover the influence of garlic (Allium sativum L.) bulb skin extract on urea and creatinine levels in alloxan-induced hyperglycemia wistar rat.
Methods: Experimental research using post-test control group design and its statistic analysis using Kruskal Wallis followed with Mann Witney test. The hyperglychemia rat is made by inducing alloxan at a single dose of 160 mg/kg bodyweight (BW) intraperitoneally. The garlic bulb skin extract doses used are 200mg/200gBW, 400mg/200gBW, and 800mg/200gBW for 14 days. The blood is sampled through vena orbitalis which is tested for its urea and creatinine levels.
Results: The urea test in hyperglychemia rat administered with 200mg/200gBB garlic bulb skin extract (average urea level 88.87 mg/dL) has no differencce from the negative group (p>0.05), while the 400mg/200gBB and 800mg/200gBB doses (average urea levels 41.86 mg/dL and 41.96 mg/dL) show significant difference (p<0.05). The creatinine test shows significant influence (p<0.05) in extract dose of 400mg/200gBB (average creatinine level 1.16 mg/dL).
Conclusion: it can be concluded that garlic bulb skin extract may have some influence in reducing urea level at 400mg/200gBB and 800mg/200gBB doses and creatinine level at 400mg/200gBB dose. |
topic |
Garlic bulb skin hyperglycemia urea and creatinine levels. |
url |
http://jurnal.unissula.ac.id/index.php/sainsmedika/article/view/1168 |
work_keys_str_mv |
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