Collectin CL-LK Is a Novel Soluble Pattern Recognition Receptor for Mycobacterium tuberculosis.
Understanding the molecular components of immune recognition of the tuberculosis (TB) bacillus, Mycobacterium tuberculosis, can help designing novel strategies to combat TB. Here, we identify collectin CL-LK as a novel soluble C-type lectin able to bind M. tuberculosis, and characterize mycobacteria...
Main Authors: | , , , , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2015-01-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC4501752?pdf=render |
id |
doaj-8152964fa72949a1be1c199f8cf0faea |
---|---|
record_format |
Article |
spelling |
doaj-8152964fa72949a1be1c199f8cf0faea2020-11-24T21:55:12ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01107e013269210.1371/journal.pone.0132692Collectin CL-LK Is a Novel Soluble Pattern Recognition Receptor for Mycobacterium tuberculosis.Anthony TroegelerGeanncarlo Lugo-VillarinoSøren HansenVoahangy RasolofoMaiken Lumby HenriksenKenichiro MoriKatsuki OhtaniCarine DuvalIngrid MercierAlan BénardJérome NigouDenis HudrisierNobutaka WakamiyaOlivier NeyrollesUnderstanding the molecular components of immune recognition of the tuberculosis (TB) bacillus, Mycobacterium tuberculosis, can help designing novel strategies to combat TB. Here, we identify collectin CL-LK as a novel soluble C-type lectin able to bind M. tuberculosis, and characterize mycobacterial mannose-capped lipoarabinomannan as a primary ligand for CL-LK. Mice deficient in CL-K1, one of the CL-LK subunits, do not display altered susceptibility to M. tuberculosis. However, we found that the amount of CL-LK in the serum of patients with active TB is reduced, compared to that in controls, and correlates inversely to the magnitude of the immune response to the pathogen. These findings indicate that CL-LK might be of interest for future diagnostic and treatment monitoring purposes.http://europepmc.org/articles/PMC4501752?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Anthony Troegeler Geanncarlo Lugo-Villarino Søren Hansen Voahangy Rasolofo Maiken Lumby Henriksen Kenichiro Mori Katsuki Ohtani Carine Duval Ingrid Mercier Alan Bénard Jérome Nigou Denis Hudrisier Nobutaka Wakamiya Olivier Neyrolles |
spellingShingle |
Anthony Troegeler Geanncarlo Lugo-Villarino Søren Hansen Voahangy Rasolofo Maiken Lumby Henriksen Kenichiro Mori Katsuki Ohtani Carine Duval Ingrid Mercier Alan Bénard Jérome Nigou Denis Hudrisier Nobutaka Wakamiya Olivier Neyrolles Collectin CL-LK Is a Novel Soluble Pattern Recognition Receptor for Mycobacterium tuberculosis. PLoS ONE |
author_facet |
Anthony Troegeler Geanncarlo Lugo-Villarino Søren Hansen Voahangy Rasolofo Maiken Lumby Henriksen Kenichiro Mori Katsuki Ohtani Carine Duval Ingrid Mercier Alan Bénard Jérome Nigou Denis Hudrisier Nobutaka Wakamiya Olivier Neyrolles |
author_sort |
Anthony Troegeler |
title |
Collectin CL-LK Is a Novel Soluble Pattern Recognition Receptor for Mycobacterium tuberculosis. |
title_short |
Collectin CL-LK Is a Novel Soluble Pattern Recognition Receptor for Mycobacterium tuberculosis. |
title_full |
Collectin CL-LK Is a Novel Soluble Pattern Recognition Receptor for Mycobacterium tuberculosis. |
title_fullStr |
Collectin CL-LK Is a Novel Soluble Pattern Recognition Receptor for Mycobacterium tuberculosis. |
title_full_unstemmed |
Collectin CL-LK Is a Novel Soluble Pattern Recognition Receptor for Mycobacterium tuberculosis. |
title_sort |
collectin cl-lk is a novel soluble pattern recognition receptor for mycobacterium tuberculosis. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2015-01-01 |
description |
Understanding the molecular components of immune recognition of the tuberculosis (TB) bacillus, Mycobacterium tuberculosis, can help designing novel strategies to combat TB. Here, we identify collectin CL-LK as a novel soluble C-type lectin able to bind M. tuberculosis, and characterize mycobacterial mannose-capped lipoarabinomannan as a primary ligand for CL-LK. Mice deficient in CL-K1, one of the CL-LK subunits, do not display altered susceptibility to M. tuberculosis. However, we found that the amount of CL-LK in the serum of patients with active TB is reduced, compared to that in controls, and correlates inversely to the magnitude of the immune response to the pathogen. These findings indicate that CL-LK might be of interest for future diagnostic and treatment monitoring purposes. |
url |
http://europepmc.org/articles/PMC4501752?pdf=render |
work_keys_str_mv |
AT anthonytroegeler collectincllkisanovelsolublepatternrecognitionreceptorformycobacteriumtuberculosis AT geanncarlolugovillarino collectincllkisanovelsolublepatternrecognitionreceptorformycobacteriumtuberculosis AT sørenhansen collectincllkisanovelsolublepatternrecognitionreceptorformycobacteriumtuberculosis AT voahangyrasolofo collectincllkisanovelsolublepatternrecognitionreceptorformycobacteriumtuberculosis AT maikenlumbyhenriksen collectincllkisanovelsolublepatternrecognitionreceptorformycobacteriumtuberculosis AT kenichiromori collectincllkisanovelsolublepatternrecognitionreceptorformycobacteriumtuberculosis AT katsukiohtani collectincllkisanovelsolublepatternrecognitionreceptorformycobacteriumtuberculosis AT carineduval collectincllkisanovelsolublepatternrecognitionreceptorformycobacteriumtuberculosis AT ingridmercier collectincllkisanovelsolublepatternrecognitionreceptorformycobacteriumtuberculosis AT alanbenard collectincllkisanovelsolublepatternrecognitionreceptorformycobacteriumtuberculosis AT jeromenigou collectincllkisanovelsolublepatternrecognitionreceptorformycobacteriumtuberculosis AT denishudrisier collectincllkisanovelsolublepatternrecognitionreceptorformycobacteriumtuberculosis AT nobutakawakamiya collectincllkisanovelsolublepatternrecognitionreceptorformycobacteriumtuberculosis AT olivierneyrolles collectincllkisanovelsolublepatternrecognitionreceptorformycobacteriumtuberculosis |
_version_ |
1725864114689933312 |