Pulmonary vascular complications in portal hypertension and liver disease: A concise review
Chronic liver disease and/or portal hypertension may be associated with one of the two pulmonary vascular complications: portopulmonary hypertension and hepatopulmonary syndrome. These pulmonary vascular disorders are notoriously underdiagnosed; however, they have a substantial negative impact on su...
Main Authors: | , , , , , |
---|---|
Format: | Article |
Language: | Spanish |
Published: |
Elsevier
2013-01-01
|
Series: | Revista de Gastroenterología de México |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S037509061200136X |
id |
doaj-8159e1326b4346b6b1b95a7400232eae |
---|---|
record_format |
Article |
spelling |
doaj-8159e1326b4346b6b1b95a7400232eae2020-11-25T00:12:39ZspaElsevierRevista de Gastroenterología de México0375-09062013-01-01781354410.1016/j.rgmx.2012.10.004Pulmonary vascular complications in portal hypertension and liver disease: A concise reviewM. Porres-Aguilar0J.F. Gallegos-Orozco1H. Garcia2J. Aguirre3R.U. Macias-Rodriguez4A. Torre-Delgadillo5Department of Internal Medicine, Division of Hospital Medicine, Texas Tech University Health Sciences Center/Paul L. Foster School of Medicine, El Paso, TX, USADivision of Gastroenterology and Hepatology, University of Utah School of Medicine, Salt Lake City, UT, USAEl Paso Respiratory and Sleep Consultants, El Paso, TX, USADepartment of Gastroenterology, Liver Unit; Instituto Nacional de Ciencias Médicas y Nutricion “Salvador Zubiran”, Mexico City, MexicoDepartment of Gastroenterology, Liver Unit; Instituto Nacional de Ciencias Médicas y Nutricion “Salvador Zubiran”, Mexico City, MexicoDepartment of Gastroenterology, Liver Unit; Instituto Nacional de Ciencias Médicas y Nutricion “Salvador Zubiran”, Mexico City, MexicoChronic liver disease and/or portal hypertension may be associated with one of the two pulmonary vascular complications: portopulmonary hypertension and hepatopulmonary syndrome. These pulmonary vascular disorders are notoriously underdiagnosed; however, they have a substantial negative impact on survival and require special attention in order to understand their diagnostic approach and to select the best therapeutic options. Portopulmonary hypertension results from excessive vasoconstriction, vascular remodeling, and proliferative and thrombotic events within the pulmonary circulation that lead to progressive right ventricular failure and ultimately to death. On the other hand, abnormal intrapulmonary vascular dilations, profound hypoxemia, and a wide alveolar-arterial gradient are the hallmarks of the hepatopulmonary syndrome, resulting in difficult-to-treat hypoxemia. The aim of this review is to summarize the latest pathophysiologic concepts, diagnostic approach, therapy, and prognosis of portopulmonary hypertension and hepatopulmonary syndrome, as well as to discuss the role of liver transplantation as a definitive therapy in selected patients with these conditions.http://www.sciencedirect.com/science/article/pii/S037509061200136XLiver diseasePortal hypertensionPulmonary hypertensionPortopulmonary hypertensionHepatopulmonary syndromeLiver transplantation |
collection |
DOAJ |
language |
Spanish |
format |
Article |
sources |
DOAJ |
author |
M. Porres-Aguilar J.F. Gallegos-Orozco H. Garcia J. Aguirre R.U. Macias-Rodriguez A. Torre-Delgadillo |
spellingShingle |
M. Porres-Aguilar J.F. Gallegos-Orozco H. Garcia J. Aguirre R.U. Macias-Rodriguez A. Torre-Delgadillo Pulmonary vascular complications in portal hypertension and liver disease: A concise review Revista de Gastroenterología de México Liver disease Portal hypertension Pulmonary hypertension Portopulmonary hypertension Hepatopulmonary syndrome Liver transplantation |
author_facet |
M. Porres-Aguilar J.F. Gallegos-Orozco H. Garcia J. Aguirre R.U. Macias-Rodriguez A. Torre-Delgadillo |
author_sort |
M. Porres-Aguilar |
title |
Pulmonary vascular complications in portal hypertension and liver disease: A concise review |
title_short |
Pulmonary vascular complications in portal hypertension and liver disease: A concise review |
title_full |
Pulmonary vascular complications in portal hypertension and liver disease: A concise review |
title_fullStr |
Pulmonary vascular complications in portal hypertension and liver disease: A concise review |
title_full_unstemmed |
Pulmonary vascular complications in portal hypertension and liver disease: A concise review |
title_sort |
pulmonary vascular complications in portal hypertension and liver disease: a concise review |
publisher |
Elsevier |
series |
Revista de Gastroenterología de México |
issn |
0375-0906 |
publishDate |
2013-01-01 |
description |
Chronic liver disease and/or portal hypertension may be associated with one of the two pulmonary vascular complications: portopulmonary hypertension and hepatopulmonary syndrome. These pulmonary vascular disorders are notoriously underdiagnosed; however, they have a substantial negative impact on survival and require special attention in order to understand their diagnostic approach and to select the best therapeutic options. Portopulmonary hypertension results from excessive vasoconstriction, vascular remodeling, and proliferative and thrombotic events within the pulmonary circulation that lead to progressive right ventricular failure and ultimately to death. On the other hand, abnormal intrapulmonary vascular dilations, profound hypoxemia, and a wide alveolar-arterial gradient are the hallmarks of the hepatopulmonary syndrome, resulting in difficult-to-treat hypoxemia. The aim of this review is to summarize the latest pathophysiologic concepts, diagnostic approach, therapy, and prognosis of portopulmonary hypertension and hepatopulmonary syndrome, as well as to discuss the role of liver transplantation as a definitive therapy in selected patients with these conditions. |
topic |
Liver disease Portal hypertension Pulmonary hypertension Portopulmonary hypertension Hepatopulmonary syndrome Liver transplantation |
url |
http://www.sciencedirect.com/science/article/pii/S037509061200136X |
work_keys_str_mv |
AT mporresaguilar pulmonaryvascularcomplicationsinportalhypertensionandliverdiseaseaconcisereview AT jfgallegosorozco pulmonaryvascularcomplicationsinportalhypertensionandliverdiseaseaconcisereview AT hgarcia pulmonaryvascularcomplicationsinportalhypertensionandliverdiseaseaconcisereview AT jaguirre pulmonaryvascularcomplicationsinportalhypertensionandliverdiseaseaconcisereview AT rumaciasrodriguez pulmonaryvascularcomplicationsinportalhypertensionandliverdiseaseaconcisereview AT atorredelgadillo pulmonaryvascularcomplicationsinportalhypertensionandliverdiseaseaconcisereview |
_version_ |
1725398381633732608 |