Association of angiotensin-converting enzyme insertion/deletion (ACE I/D) and angiotensinogen (AGT M235T) polymorphisms with the risk of obesity in a Tunisian population
Objective: This study aims to determine whether genetic variants in ACE I/D and AGT M235T are associated with overweight-obesity and body mass index (BMI) in a Tunisian population. Methods: We designed an age- and sex-matched case-control study. The height and weight were measured and BMI was calcul...
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Series: | Journal of the Renin-Angiotensin-Aldosterone System |
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doaj-815a7c8a5ebe401c85dab641317072db2021-05-02T23:29:56ZengHindawi - SAGE PublishingJournal of the Renin-Angiotensin-Aldosterone System1752-89762020-04-012110.1177/1470320320907820Association of angiotensin-converting enzyme insertion/deletion (ACE I/D) and angiotensinogen (AGT M235T) polymorphisms with the risk of obesity in a Tunisian populationWided Khamlaoui0Sounira Mehri1Sonia Hammami2Roberto Elosua3Mohamed Hammami4Biochemistry Laboratory, LR12ES05 “Nutrition-Functional Foods and Vascular Health”, Faculty of Medicine, University of Monastir, TunisiaBiochemistry Laboratory, LR12ES05 “Nutrition-Functional Foods and Vascular Health”, Faculty of Medicine, University of Monastir, TunisiaDepartment of Internal Medicine, CHU F. Bourguiba, TunisiaCardiovascular Epidemiology and Genetics, Institut Hospital del Mar d’Investigacions Mèdiques, SpainBiochemistry Laboratory, LR12ES05 “Nutrition-Functional Foods and Vascular Health”, Faculty of Medicine, University of Monastir, TunisiaObjective: This study aims to determine whether genetic variants in ACE I/D and AGT M235T are associated with overweight-obesity and body mass index (BMI) in a Tunisian population. Methods: We designed an age- and sex-matched case-control study. The height and weight were measured and BMI was calculated. A total of 259 overweight-obese patients and 369 healthy controls were genotyped for the ACE I/D and AGT M235T genes using polymerase chain reaction and restriction fragment length polymorphism. Results: ACE I/D and AGT M235T genes were associated with BMI, waist circumference and overweight-obesity (p⩽0.001). In an additive model, the I and the M alleles in ACE and AGT variants, respectively, were associated with a lower BMI: –1.45 and −2.29 units, respectively. ACE I/D genotypes were associated with dyslipidemia; AGT M235T genotypes with dyslipidemia and total cholesterol. Conclusion: These data suggest that variations in ACE I/D and AGT M235T affect the risk of overweight-obesity, BMI and dyslipidemia, and could point to a key molecular pathway of metabolic syndrome and its related comorbidities.https://doi.org/10.1177/1470320320907820 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Wided Khamlaoui Sounira Mehri Sonia Hammami Roberto Elosua Mohamed Hammami |
spellingShingle |
Wided Khamlaoui Sounira Mehri Sonia Hammami Roberto Elosua Mohamed Hammami Association of angiotensin-converting enzyme insertion/deletion (ACE I/D) and angiotensinogen (AGT M235T) polymorphisms with the risk of obesity in a Tunisian population Journal of the Renin-Angiotensin-Aldosterone System |
author_facet |
Wided Khamlaoui Sounira Mehri Sonia Hammami Roberto Elosua Mohamed Hammami |
author_sort |
Wided Khamlaoui |
title |
Association of angiotensin-converting enzyme insertion/deletion (ACE I/D) and angiotensinogen (AGT M235T) polymorphisms with the risk of obesity in a Tunisian population |
title_short |
Association of angiotensin-converting enzyme insertion/deletion (ACE I/D) and angiotensinogen (AGT M235T) polymorphisms with the risk of obesity in a Tunisian population |
title_full |
Association of angiotensin-converting enzyme insertion/deletion (ACE I/D) and angiotensinogen (AGT M235T) polymorphisms with the risk of obesity in a Tunisian population |
title_fullStr |
Association of angiotensin-converting enzyme insertion/deletion (ACE I/D) and angiotensinogen (AGT M235T) polymorphisms with the risk of obesity in a Tunisian population |
title_full_unstemmed |
Association of angiotensin-converting enzyme insertion/deletion (ACE I/D) and angiotensinogen (AGT M235T) polymorphisms with the risk of obesity in a Tunisian population |
title_sort |
association of angiotensin-converting enzyme insertion/deletion (ace i/d) and angiotensinogen (agt m235t) polymorphisms with the risk of obesity in a tunisian population |
publisher |
Hindawi - SAGE Publishing |
series |
Journal of the Renin-Angiotensin-Aldosterone System |
issn |
1752-8976 |
publishDate |
2020-04-01 |
description |
Objective: This study aims to determine whether genetic variants in ACE I/D and AGT M235T are associated with overweight-obesity and body mass index (BMI) in a Tunisian population. Methods: We designed an age- and sex-matched case-control study. The height and weight were measured and BMI was calculated. A total of 259 overweight-obese patients and 369 healthy controls were genotyped for the ACE I/D and AGT M235T genes using polymerase chain reaction and restriction fragment length polymorphism. Results: ACE I/D and AGT M235T genes were associated with BMI, waist circumference and overweight-obesity (p⩽0.001). In an additive model, the I and the M alleles in ACE and AGT variants, respectively, were associated with a lower BMI: –1.45 and −2.29 units, respectively. ACE I/D genotypes were associated with dyslipidemia; AGT M235T genotypes with dyslipidemia and total cholesterol. Conclusion: These data suggest that variations in ACE I/D and AGT M235T affect the risk of overweight-obesity, BMI and dyslipidemia, and could point to a key molecular pathway of metabolic syndrome and its related comorbidities. |
url |
https://doi.org/10.1177/1470320320907820 |
work_keys_str_mv |
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