Relationship between retinal blood flow and cytokines in central retinal vein occlusion
Abstract Background We evaluated the relationship between retinal blood flow and aqueous humor levels of cytokines/growth factors in patients with central retinal vein occlusion (CRVO). Methods In an observational study, 64 eyes of 64 CRVO patients were examined before anti-vascular endothelial grow...
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doaj-8169104abb0e44728c81f44104ea878e2020-11-25T03:26:19ZengBMCBMC Ophthalmology1471-24152020-06-012011810.1186/s12886-020-01486-xRelationship between retinal blood flow and cytokines in central retinal vein occlusionHidetaka Noma0Kanako Yasuda1Tatsuya Mimura2Akemi Ofusa3Masahiko Shimura4Department of Ophthalmology, Hachioji Medical Center, Tokyo Medical UniversityDepartment of Ophthalmology, Hachioji Medical Center, Tokyo Medical UniversityDepartment of Ophthalmology, Teikyo University School of MedicineDepartment of Ophthalmology, Hachioji Medical Center, Tokyo Medical UniversityDepartment of Ophthalmology, Hachioji Medical Center, Tokyo Medical UniversityAbstract Background We evaluated the relationship between retinal blood flow and aqueous humor levels of cytokines/growth factors in patients with central retinal vein occlusion (CRVO). Methods In an observational study, 64 eyes of 64 CRVO patients were examined before anti-vascular endothelial growth factor (VEGF) therapy. Blood flow was assessed in large vessels around and at the optic disk by determining the mean blur rate using laser speckle flowgraphy. Aqueous humor samples were obtained from the patients during anti-VEGF therapy and levels of the following molecules were measured by the suspension array method: soluble VEGF receptor (sVEGFR)-1, sVEGFR-2, VEGF, plancental growth factor (PlGF), platelet-derived growth factor (PDGF)-AA, soluble intercellular adhesion molecule (sICAM)-1, monocyte chemotactic protein (MCP)-1, interleukin (IL)-6, IL-8, IL-12(p70), and IL-13. Results The mean blur rate of the affected eye was significantly lower than that of the unaffected eye. The mean blur rate showed a significant negative correlation with the log-transformed aqueous humor levels of PlGF, sICAM-1, and IL-8, but not VEGF. Conclusions These findings suggest that retinal blood flow velocity might be more strongly correlated with inflammatory factors than VEGF in patients with nonischemic CRVO and macular edema.http://link.springer.com/article/10.1186/s12886-020-01486-xCentral retinal vein occlusionLaser speckle flowgraphyRetinal blood flowPlacental growth factorSoluble intercellular adhesion molecule-1Interleukin-8 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hidetaka Noma Kanako Yasuda Tatsuya Mimura Akemi Ofusa Masahiko Shimura |
spellingShingle |
Hidetaka Noma Kanako Yasuda Tatsuya Mimura Akemi Ofusa Masahiko Shimura Relationship between retinal blood flow and cytokines in central retinal vein occlusion BMC Ophthalmology Central retinal vein occlusion Laser speckle flowgraphy Retinal blood flow Placental growth factor Soluble intercellular adhesion molecule-1 Interleukin-8 |
author_facet |
Hidetaka Noma Kanako Yasuda Tatsuya Mimura Akemi Ofusa Masahiko Shimura |
author_sort |
Hidetaka Noma |
title |
Relationship between retinal blood flow and cytokines in central retinal vein occlusion |
title_short |
Relationship between retinal blood flow and cytokines in central retinal vein occlusion |
title_full |
Relationship between retinal blood flow and cytokines in central retinal vein occlusion |
title_fullStr |
Relationship between retinal blood flow and cytokines in central retinal vein occlusion |
title_full_unstemmed |
Relationship between retinal blood flow and cytokines in central retinal vein occlusion |
title_sort |
relationship between retinal blood flow and cytokines in central retinal vein occlusion |
publisher |
BMC |
series |
BMC Ophthalmology |
issn |
1471-2415 |
publishDate |
2020-06-01 |
description |
Abstract Background We evaluated the relationship between retinal blood flow and aqueous humor levels of cytokines/growth factors in patients with central retinal vein occlusion (CRVO). Methods In an observational study, 64 eyes of 64 CRVO patients were examined before anti-vascular endothelial growth factor (VEGF) therapy. Blood flow was assessed in large vessels around and at the optic disk by determining the mean blur rate using laser speckle flowgraphy. Aqueous humor samples were obtained from the patients during anti-VEGF therapy and levels of the following molecules were measured by the suspension array method: soluble VEGF receptor (sVEGFR)-1, sVEGFR-2, VEGF, plancental growth factor (PlGF), platelet-derived growth factor (PDGF)-AA, soluble intercellular adhesion molecule (sICAM)-1, monocyte chemotactic protein (MCP)-1, interleukin (IL)-6, IL-8, IL-12(p70), and IL-13. Results The mean blur rate of the affected eye was significantly lower than that of the unaffected eye. The mean blur rate showed a significant negative correlation with the log-transformed aqueous humor levels of PlGF, sICAM-1, and IL-8, but not VEGF. Conclusions These findings suggest that retinal blood flow velocity might be more strongly correlated with inflammatory factors than VEGF in patients with nonischemic CRVO and macular edema. |
topic |
Central retinal vein occlusion Laser speckle flowgraphy Retinal blood flow Placental growth factor Soluble intercellular adhesion molecule-1 Interleukin-8 |
url |
http://link.springer.com/article/10.1186/s12886-020-01486-x |
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