Salvage Radiosurgery for Selected Patients with Recurrent Malignant Gliomas
Purpose. To analyse the survival after salvage radiosurgery and to identify prognostic factors. Methods. We retrospectively reviewed 87 consecutive patients, with recurrent high-grade glioma, that underwent stereotactic radiosurgery between 1997 and 2010. We evaluated the survival after initial diag...
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doaj-8187e2ad3fdc4ae691c9331aa8e117822020-11-24T20:56:58ZengHindawi LimitedBioMed Research International2314-61332314-61412014-01-01201410.1155/2014/657953657953Salvage Radiosurgery for Selected Patients with Recurrent Malignant GliomasMiguel Martínez-Carrillo0Isabel Tovar-Martín1Mercedes Zurita-Herrera2Rosario Del Moral-Ávila3Rosario Guerrero-Tejada4Enrique Saura-Rojas5Juan Luis Osorio-Ceballos6Juan Pedro Arrebola-Moreno7José Expósito-Hernández8Radiation Oncology Department, Virgen de las Nieves University Hospital, 18014 Granada, SpainRadiation Oncology Department, Virgen de las Nieves University Hospital, 18014 Granada, SpainRadiation Oncology Department, Virgen de las Nieves University Hospital, 18014 Granada, SpainRadiation Oncology Department, Virgen de las Nieves University Hospital, 18014 Granada, SpainRadiation Oncology Department, Virgen de las Nieves University Hospital, 18014 Granada, SpainNeurosurgery Department, Virgen de las Nieves University Hospital, 18014 Granada, SpainMedical Physics Department, Virgen de las Nieves University Hospital, 18014 Granada, SpainRadiation Oncology Department, Virgen de las Nieves University Hospital, 18014 Granada, SpainRadiation Oncology Department, Virgen de las Nieves University Hospital, 18014 Granada, SpainPurpose. To analyse the survival after salvage radiosurgery and to identify prognostic factors. Methods. We retrospectively reviewed 87 consecutive patients, with recurrent high-grade glioma, that underwent stereotactic radiosurgery between 1997 and 2010. We evaluated the survival after initial diagnosis and after reirradiation. The prognostic factors were analysed by bivariate and multivariate Cox regression model. Results. The median age was 48 years old. The primary histology included anaplastic astrocytoma (47%) and glioblastoma (53%). A margin dose of 18 Gy was administered in the majority of cases (74%). The median survival after initial diagnosis was 21 months (39 months for anaplastic astrocytoma and 18.5 months for glioblastoma) and after reirradiation it was 10 months (17 months for anaplastic astrocytoma and 7.5 months for glioblastoma). In the bivariate analyses, the prognostic factors significantly associated with survival after reirradiation were age, tumour and treatment volume at recurrence, recursive partitioning analyses classification, Karnofsky performance score, histology, and margin to the planning target volume. Only the last four showed significant association in the multivariate analyses. Conclusion. stereotactic radiosurgery is a safe and may be an effective treatment option for selected patients diagnosed with recurrent high-grade glioma. The identified prognostic factors could help individualise the treatment.http://dx.doi.org/10.1155/2014/657953 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Miguel Martínez-Carrillo Isabel Tovar-Martín Mercedes Zurita-Herrera Rosario Del Moral-Ávila Rosario Guerrero-Tejada Enrique Saura-Rojas Juan Luis Osorio-Ceballos Juan Pedro Arrebola-Moreno José Expósito-Hernández |
spellingShingle |
Miguel Martínez-Carrillo Isabel Tovar-Martín Mercedes Zurita-Herrera Rosario Del Moral-Ávila Rosario Guerrero-Tejada Enrique Saura-Rojas Juan Luis Osorio-Ceballos Juan Pedro Arrebola-Moreno José Expósito-Hernández Salvage Radiosurgery for Selected Patients with Recurrent Malignant Gliomas BioMed Research International |
author_facet |
Miguel Martínez-Carrillo Isabel Tovar-Martín Mercedes Zurita-Herrera Rosario Del Moral-Ávila Rosario Guerrero-Tejada Enrique Saura-Rojas Juan Luis Osorio-Ceballos Juan Pedro Arrebola-Moreno José Expósito-Hernández |
author_sort |
Miguel Martínez-Carrillo |
title |
Salvage Radiosurgery for Selected Patients with Recurrent Malignant Gliomas |
title_short |
Salvage Radiosurgery for Selected Patients with Recurrent Malignant Gliomas |
title_full |
Salvage Radiosurgery for Selected Patients with Recurrent Malignant Gliomas |
title_fullStr |
Salvage Radiosurgery for Selected Patients with Recurrent Malignant Gliomas |
title_full_unstemmed |
Salvage Radiosurgery for Selected Patients with Recurrent Malignant Gliomas |
title_sort |
salvage radiosurgery for selected patients with recurrent malignant gliomas |
publisher |
Hindawi Limited |
series |
BioMed Research International |
issn |
2314-6133 2314-6141 |
publishDate |
2014-01-01 |
description |
Purpose. To analyse the survival after salvage radiosurgery and to identify prognostic factors. Methods. We retrospectively reviewed 87 consecutive patients, with recurrent high-grade glioma, that underwent stereotactic radiosurgery between 1997 and 2010. We evaluated the survival after initial diagnosis and after reirradiation. The prognostic factors were analysed by bivariate and multivariate Cox regression model. Results. The median age was 48 years old. The primary histology included anaplastic astrocytoma (47%) and glioblastoma (53%). A margin dose of 18 Gy was administered in the majority of cases (74%). The median survival after initial diagnosis was 21 months (39 months for anaplastic astrocytoma and 18.5 months for glioblastoma) and after reirradiation it was 10 months (17 months for anaplastic astrocytoma and 7.5 months for glioblastoma). In the bivariate analyses, the prognostic factors significantly associated with survival after reirradiation were age, tumour and treatment volume at recurrence, recursive partitioning analyses classification, Karnofsky performance score, histology, and margin to the planning target volume. Only the last four showed significant association in the multivariate analyses. Conclusion. stereotactic radiosurgery is a safe and may be an effective treatment option for selected patients diagnosed with recurrent high-grade glioma. The identified prognostic factors could help individualise the treatment. |
url |
http://dx.doi.org/10.1155/2014/657953 |
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