Seroprevalence of hepatitis virus infection in men who have sex with men aged 18–40 years in Taiwan
Men who have sex with men (MSM) are at increased risk for hepatitis A virus (HAV), hepatitis B virus (HBV), and hepatitis C virus (HCV) infections than the general population. Comparisons of the seroprevalence rates of these hepatitis viruses between HIV-positive and HIV-negative MSM are rarely perf...
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doaj-818c5a4e7ff941cd89648123ccd3bee62020-11-24T22:59:15ZengElsevierJournal of the Formosan Medical Association0929-66462012-08-01111843143810.1016/j.jfma.2011.06.022Seroprevalence of hepatitis virus infection in men who have sex with men aged 18–40 years in TaiwanYu-Tzu Tseng0Hsin-Yun Sun1Sui-Yuan Chang2Cheng-Hsin Wu3Wen-Chun Liu4Pei-Ying Wu5Ching-Lan Lu6Chia-Yin Hsieh7Chien-Ching Hung8Department of Traumatology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, TaiwanDepartment of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, TaiwanDepartment of Laboratory Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, TaiwanDepartment of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, TaiwanDepartment of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, TaiwanDepartment of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, TaiwanDepartment of Internal Medicine, National Taiwan University Hospital Hsin-Chu Branch, Hsin-Chu, TaiwanDepartment of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, TaiwanDepartment of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, TaiwanMen who have sex with men (MSM) are at increased risk for hepatitis A virus (HAV), hepatitis B virus (HBV), and hepatitis C virus (HCV) infections than the general population. Comparisons of the seroprevalence rates of these hepatitis viruses between HIV-positive and HIV-negative MSM are rarely performed in Taiwan. Methods: Between January 2009 and June 2010, data on the serologies for HAV, HBV, and HCV were collected from two groups of patients: HIV-negative MSM, aged 18–40 years, who sought voluntary counseling and testing (VCT) for HIV infection, and HIV-positive MSM of the same age group who sought HIV care at the National Taiwan University Hospital. Both groups of patients were also tested for syphilis. Results: During the 18-month study period, 690 HIV-negative MSM and 438 HIV-positive MSM were enrolled and tested for anti-HAV antibody, HBV surface antigen (HBsAg), hepatitis B core antibody (anti-HBc antibody), and anti-HCV antibody. HIV-positive MSM were older than HIV-negative MSM (30.5 ± 5.4 vs. 25.8 ± 4.7 years, p < 0.01). For HIV-positive MSM, the mean CD4 lymphocyte count was 477.6 ± 230.0 cells/μL and 46% of them had undetectable plasma HIV RNA load (< 40 copies/mL by reverse transcription-polymerase chain reaction assay). The overall seroprevalence rates of HAV, HBsAg, and HCV in HIV-positive MSM were 15.1%, 16.4%, and 5.5%, respectively, while in HIV-negative MSM, they were 7.4%, 6.2%, and 0.4%, respectively. In the multivariate analysis, age was significantly associated with seropositivity for HAV (OR [per one age group increase]: 1.96; 95% CI: 1.6–2.5), HBsAg (OR: 2.02; 95% CI: 1.6–2.6), anti-HBc (OR: 2.68; 95% CI: 2.3–3.2), anti-HCV (OR: 1.67; 95% CI: 1.0–2.7), and anti-HBs (OR: 1.25; 95% CI: 1.0–1.5). HIV infection was associated with seropositivity for HBsAg (OR: 1.73; 95% CI: 1.1–2.7), anti-HBc (OR: 2.44; 95% CI: 1.8–3.3), HCV (OR: 8.91; 95% CI: 2.5–31.4), and syphilis (OR: 11.21; 95% CI: 6.7–18.9). Conclusion: HIV-positive MSM have a higher seroprevalence rate of HBV and HCV infection than HIV-negative MSM in Taiwan. Vaccination and safe-sex counseling should be provided to prevent the transmission of hepatitis viruses among MSM who may be engaged in high-risk behaviors.http://www.sciencedirect.com/science/article/pii/S092966461200068Xhepatitis A virushepatitis B virushepatitis C virusHIV infectionmale homosexualmen who have sex with menseroprevalence |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yu-Tzu Tseng Hsin-Yun Sun Sui-Yuan Chang Cheng-Hsin Wu Wen-Chun Liu Pei-Ying Wu Ching-Lan Lu Chia-Yin Hsieh Chien-Ching Hung |
spellingShingle |
Yu-Tzu Tseng Hsin-Yun Sun Sui-Yuan Chang Cheng-Hsin Wu Wen-Chun Liu Pei-Ying Wu Ching-Lan Lu Chia-Yin Hsieh Chien-Ching Hung Seroprevalence of hepatitis virus infection in men who have sex with men aged 18–40 years in Taiwan Journal of the Formosan Medical Association hepatitis A virus hepatitis B virus hepatitis C virus HIV infection male homosexual men who have sex with men seroprevalence |
author_facet |
Yu-Tzu Tseng Hsin-Yun Sun Sui-Yuan Chang Cheng-Hsin Wu Wen-Chun Liu Pei-Ying Wu Ching-Lan Lu Chia-Yin Hsieh Chien-Ching Hung |
author_sort |
Yu-Tzu Tseng |
title |
Seroprevalence of hepatitis virus infection in men who have sex with men aged 18–40 years in Taiwan |
title_short |
Seroprevalence of hepatitis virus infection in men who have sex with men aged 18–40 years in Taiwan |
title_full |
Seroprevalence of hepatitis virus infection in men who have sex with men aged 18–40 years in Taiwan |
title_fullStr |
Seroprevalence of hepatitis virus infection in men who have sex with men aged 18–40 years in Taiwan |
title_full_unstemmed |
Seroprevalence of hepatitis virus infection in men who have sex with men aged 18–40 years in Taiwan |
title_sort |
seroprevalence of hepatitis virus infection in men who have sex with men aged 18–40 years in taiwan |
publisher |
Elsevier |
series |
Journal of the Formosan Medical Association |
issn |
0929-6646 |
publishDate |
2012-08-01 |
description |
Men who have sex with men (MSM) are at increased risk for hepatitis A virus (HAV), hepatitis B virus (HBV), and hepatitis C virus (HCV) infections than the general population. Comparisons of the seroprevalence rates of these hepatitis viruses between HIV-positive and HIV-negative MSM are rarely performed in Taiwan.
Methods: Between January 2009 and June 2010, data on the serologies for HAV, HBV, and HCV were collected from two groups of patients: HIV-negative MSM, aged 18–40 years, who sought voluntary counseling and testing (VCT) for HIV infection, and HIV-positive MSM of the same age group who sought HIV care at the National Taiwan University Hospital. Both groups of patients were also tested for syphilis.
Results: During the 18-month study period, 690 HIV-negative MSM and 438 HIV-positive MSM were enrolled and tested for anti-HAV antibody, HBV surface antigen (HBsAg), hepatitis B core antibody (anti-HBc antibody), and anti-HCV antibody. HIV-positive MSM were older than HIV-negative MSM (30.5 ± 5.4 vs. 25.8 ± 4.7 years, p < 0.01). For HIV-positive MSM, the mean CD4 lymphocyte count was 477.6 ± 230.0 cells/μL and 46% of them had undetectable plasma HIV RNA load (< 40 copies/mL by reverse transcription-polymerase chain reaction assay). The overall seroprevalence rates of HAV, HBsAg, and HCV in HIV-positive MSM were 15.1%, 16.4%, and 5.5%, respectively, while in HIV-negative MSM, they were 7.4%, 6.2%, and 0.4%, respectively. In the multivariate analysis, age was significantly associated with seropositivity for HAV (OR [per one age group increase]: 1.96; 95% CI: 1.6–2.5), HBsAg (OR: 2.02; 95% CI: 1.6–2.6), anti-HBc (OR: 2.68; 95% CI: 2.3–3.2), anti-HCV (OR: 1.67; 95% CI: 1.0–2.7), and anti-HBs (OR: 1.25; 95% CI: 1.0–1.5). HIV infection was associated with seropositivity for HBsAg (OR: 1.73; 95% CI: 1.1–2.7), anti-HBc (OR: 2.44; 95% CI: 1.8–3.3), HCV (OR: 8.91; 95% CI: 2.5–31.4), and syphilis (OR: 11.21; 95% CI: 6.7–18.9).
Conclusion: HIV-positive MSM have a higher seroprevalence rate of HBV and HCV infection than HIV-negative MSM in Taiwan. Vaccination and safe-sex counseling should be provided to prevent the transmission of hepatitis viruses among MSM who may be engaged in high-risk behaviors. |
topic |
hepatitis A virus hepatitis B virus hepatitis C virus HIV infection male homosexual men who have sex with men seroprevalence |
url |
http://www.sciencedirect.com/science/article/pii/S092966461200068X |
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