Aberrant MicroRNAs in Pancreatic Cancer: Researches and Clinical Implications

Aberrant MicroRNAs in Pancreatic Cancer: Researches and Clinical Implications

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy with a high rate of mortality and poor prognosis. Numerous studies have proved that microRNA (miRNA) may play a vital role in a wide range of malignancies, including PDAC, and dysregulated miRNAs, including circulating miRNAs, are a...

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Main Authors: Tao Sun, Xiangyu Kong, Yiqi Du, Zhaoshen Li
Format: Article
Language:English
Published: Hindawi Limited 2014-01-01
Series:Gastroenterology Research and Practice
Online Access:http://dx.doi.org/10.1155/2014/386561
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spelling doaj-818f8205b1ad4958a10473c21272189e2020-11-24T21:40:23ZengHindawi LimitedGastroenterology Research and Practice1687-61211687-630X2014-01-01201410.1155/2014/386561386561Aberrant MicroRNAs in Pancreatic Cancer: Researches and Clinical ImplicationsTao Sun0Xiangyu Kong1Yiqi Du2Zhaoshen Li3Department of Gastroenterology, Changhai Hospital, Second Military Medical University, 168 Changhai Road, Shanghai 200433, ChinaDepartment of Gastroenterology, Changhai Hospital, Second Military Medical University, 168 Changhai Road, Shanghai 200433, ChinaDepartment of Gastroenterology, Changhai Hospital, Second Military Medical University, 168 Changhai Road, Shanghai 200433, ChinaDepartment of Gastroenterology, Changhai Hospital, Second Military Medical University, 168 Changhai Road, Shanghai 200433, ChinaPancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy with a high rate of mortality and poor prognosis. Numerous studies have proved that microRNA (miRNA) may play a vital role in a wide range of malignancies, including PDAC, and dysregulated miRNAs, including circulating miRNAs, are associated with PDAC proliferation, invasion, chemosensitivity, and radiosensitivity, as well as prognosis. Greater understanding of the roles of miRNAs in PDAC could provide insights into this disease and identify potential diagnostic markers and therapeutic targets. The current review focuses on recent advances with respect to the roles of miRNAs in PDAC and their practical value.http://dx.doi.org/10.1155/2014/386561
collection DOAJ
language English
format Article
sources DOAJ
author Tao Sun
Xiangyu Kong
Yiqi Du
Zhaoshen Li
spellingShingle Tao Sun
Xiangyu Kong
Yiqi Du
Zhaoshen Li
Aberrant MicroRNAs in Pancreatic Cancer: Researches and Clinical Implications
Gastroenterology Research and Practice
author_facet Tao Sun
Xiangyu Kong
Yiqi Du
Zhaoshen Li
author_sort Tao Sun
title Aberrant MicroRNAs in Pancreatic Cancer: Researches and Clinical Implications
title_short Aberrant MicroRNAs in Pancreatic Cancer: Researches and Clinical Implications
title_full Aberrant MicroRNAs in Pancreatic Cancer: Researches and Clinical Implications
title_fullStr Aberrant MicroRNAs in Pancreatic Cancer: Researches and Clinical Implications
title_full_unstemmed Aberrant MicroRNAs in Pancreatic Cancer: Researches and Clinical Implications
title_sort aberrant micrornas in pancreatic cancer: researches and clinical implications
publisher Hindawi Limited
series Gastroenterology Research and Practice
issn 1687-6121
1687-630X
publishDate 2014-01-01
description Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy with a high rate of mortality and poor prognosis. Numerous studies have proved that microRNA (miRNA) may play a vital role in a wide range of malignancies, including PDAC, and dysregulated miRNAs, including circulating miRNAs, are associated with PDAC proliferation, invasion, chemosensitivity, and radiosensitivity, as well as prognosis. Greater understanding of the roles of miRNAs in PDAC could provide insights into this disease and identify potential diagnostic markers and therapeutic targets. The current review focuses on recent advances with respect to the roles of miRNAs in PDAC and their practical value.
url http://dx.doi.org/10.1155/2014/386561
work_keys_str_mv AT taosun aberrantmicrornasinpancreaticcancerresearchesandclinicalimplications
AT xiangyukong aberrantmicrornasinpancreaticcancerresearchesandclinicalimplications
AT yiqidu aberrantmicrornasinpancreaticcancerresearchesandclinicalimplications
AT zhaoshenli aberrantmicrornasinpancreaticcancerresearchesandclinicalimplications
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