Genetic causes of nonsyndromic forms of azoospermia and severe oligozoospermia in infertility men
Spermatogenesis is a complex biological process of male germ cells differentiation and maturation involving more than 2300 genes in the human. Until recently, only a small part of them was investigated in severe pathozoospermia and male infertility. During the last years clinical utilisation of geno...
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doaj-818fc07d81164b45945ff67e925e58bf2021-07-29T09:03:55ZrusABV-pressAndrologiâ i Genitalʹnaâ Hirurgiâ2070-97812019-06-01202162810.17650/2070-9781-2019-20-2-16-28319Genetic causes of nonsyndromic forms of azoospermia and severe oligozoospermia in infertility menO. A. Solovova0V. B. Chernykh1Research Centre for Medical GeneticsResearch Centre for Medical Genetics; Pirogov Russian National Research Medical UniversitySpermatogenesis is a complex biological process of male germ cells differentiation and maturation involving more than 2300 genes in the human. Until recently, only a small part of them was investigated in severe pathozoospermia and male infertility. During the last years clinical utilisation of genomic data obtained by technologies, such as whole exome sequencing and array comparative genomic hybridization, has significantly expanded the opportunities of genomic and cytogenomic analysis, the detecting of multiple pathogenic mutations/variants and copy number variations related to different genetic syndromes and inherited disorders, including male and female infertility. This review provides an update on the genetics of male infertility, presenting a number of genes which related to non-syndromal male infertility as-sotiated with azoospermia and severe oligozoospermia.https://agx.abvpress.ru/jour/article/view/348male infertilitygene mutationsazoospermiaoligozoospermiaspermatogenesismale germ cellsmeiosis |
collection |
DOAJ |
language |
Russian |
format |
Article |
sources |
DOAJ |
author |
O. A. Solovova V. B. Chernykh |
spellingShingle |
O. A. Solovova V. B. Chernykh Genetic causes of nonsyndromic forms of azoospermia and severe oligozoospermia in infertility men Andrologiâ i Genitalʹnaâ Hirurgiâ male infertility gene mutations azoospermia oligozoospermia spermatogenesis male germ cells meiosis |
author_facet |
O. A. Solovova V. B. Chernykh |
author_sort |
O. A. Solovova |
title |
Genetic causes of nonsyndromic forms of azoospermia and severe oligozoospermia in infertility men |
title_short |
Genetic causes of nonsyndromic forms of azoospermia and severe oligozoospermia in infertility men |
title_full |
Genetic causes of nonsyndromic forms of azoospermia and severe oligozoospermia in infertility men |
title_fullStr |
Genetic causes of nonsyndromic forms of azoospermia and severe oligozoospermia in infertility men |
title_full_unstemmed |
Genetic causes of nonsyndromic forms of azoospermia and severe oligozoospermia in infertility men |
title_sort |
genetic causes of nonsyndromic forms of azoospermia and severe oligozoospermia in infertility men |
publisher |
ABV-press |
series |
Andrologiâ i Genitalʹnaâ Hirurgiâ |
issn |
2070-9781 |
publishDate |
2019-06-01 |
description |
Spermatogenesis is a complex biological process of male germ cells differentiation and maturation involving more than 2300 genes in the human. Until recently, only a small part of them was investigated in severe pathozoospermia and male infertility. During the last years clinical utilisation of genomic data obtained by technologies, such as whole exome sequencing and array comparative genomic hybridization, has significantly expanded the opportunities of genomic and cytogenomic analysis, the detecting of multiple pathogenic mutations/variants and copy number variations related to different genetic syndromes and inherited disorders, including male and female infertility. This review provides an update on the genetics of male infertility, presenting a number of genes which related to non-syndromal male infertility as-sotiated with azoospermia and severe oligozoospermia. |
topic |
male infertility gene mutations azoospermia oligozoospermia spermatogenesis male germ cells meiosis |
url |
https://agx.abvpress.ru/jour/article/view/348 |
work_keys_str_mv |
AT oasolovova geneticcausesofnonsyndromicformsofazoospermiaandsevereoligozoospermiaininfertilitymen AT vbchernykh geneticcausesofnonsyndromicformsofazoospermiaandsevereoligozoospermiaininfertilitymen |
_version_ |
1721249400973426688 |