Pathological Features of New Animal Models for Primary Biliary Cirrhosis
Primary biliary cirrhosis (PBC) is an autoimmune liver disease characterized by immune mediated biliary damage and frequent appearance of autoantibodies against mitochondrial enzymes. There is almost no useful animal model that is globally recognized and routinely used, however, several unique anima...
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2012-01-01
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Series: | International Journal of Hepatology |
Online Access: | http://dx.doi.org/10.1155/2012/403954 |
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doaj-8192651afb7847209fe584eb08e9e8622020-11-24T22:39:49ZengHindawi LimitedInternational Journal of Hepatology2090-34482090-34562012-01-01201210.1155/2012/403954403954Pathological Features of New Animal Models for Primary Biliary CirrhosisKoichi Tsuneyama0Yuki Moritoki1Kentaro Kikuchi2Yasuni Nakanuma3Department of Diagnostic Pathology, Graduate School of Medicine and Pharmaceutical Science, University of Toyama, 2630 Sugitani, Toyama 930-0194, JapanDepartment of Infection, Allergy, Clinical Immunology and Laboratory Medicine, Graduate School of Medicine, Akita University, Hondo, Akita 010-8543, JapanFourth Department of Internal Medicine, Mizonokuchi Hospital, Teikyo University School of Medicine, Takatsu-ku, Kawasaki 213-8507, JapanDepartment of Human Pathology, Graduate School of Medicine, Kanazawa University, Kanazawa 920-8640, JapanPrimary biliary cirrhosis (PBC) is an autoimmune liver disease characterized by immune mediated biliary damage and frequent appearance of autoantibodies against mitochondrial enzymes. There is almost no useful animal model that is globally recognized and routinely used, however, several unique animal models manifested the characteristic clinical and pathological features of human PBC within the last 5 years. Herein, we compare the pathological features of previously reported and newly introduced novel animal models of PBC. Knowledge and understanding of the strengths and the limitations of each animal model have led to the development of promising therapies and novel tools to characterize these clinical conditions. Moreover, suitability of the model for the intended purpose should be confirmed by further research and analysis.http://dx.doi.org/10.1155/2012/403954 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Koichi Tsuneyama Yuki Moritoki Kentaro Kikuchi Yasuni Nakanuma |
spellingShingle |
Koichi Tsuneyama Yuki Moritoki Kentaro Kikuchi Yasuni Nakanuma Pathological Features of New Animal Models for Primary Biliary Cirrhosis International Journal of Hepatology |
author_facet |
Koichi Tsuneyama Yuki Moritoki Kentaro Kikuchi Yasuni Nakanuma |
author_sort |
Koichi Tsuneyama |
title |
Pathological Features of New Animal Models for Primary Biliary Cirrhosis |
title_short |
Pathological Features of New Animal Models for Primary Biliary Cirrhosis |
title_full |
Pathological Features of New Animal Models for Primary Biliary Cirrhosis |
title_fullStr |
Pathological Features of New Animal Models for Primary Biliary Cirrhosis |
title_full_unstemmed |
Pathological Features of New Animal Models for Primary Biliary Cirrhosis |
title_sort |
pathological features of new animal models for primary biliary cirrhosis |
publisher |
Hindawi Limited |
series |
International Journal of Hepatology |
issn |
2090-3448 2090-3456 |
publishDate |
2012-01-01 |
description |
Primary biliary cirrhosis (PBC) is an autoimmune liver disease characterized by immune mediated biliary damage and frequent appearance of autoantibodies against mitochondrial enzymes. There is almost no useful animal model that is globally recognized and routinely used, however, several unique animal models manifested the characteristic clinical and pathological features of human PBC within the last 5 years. Herein, we compare the pathological features of previously reported and newly introduced novel animal models of PBC. Knowledge and understanding of the strengths and the limitations of each animal model have led to the development of promising therapies and novel tools to characterize these clinical conditions. Moreover, suitability of the model for the intended purpose should be confirmed by further research and analysis. |
url |
http://dx.doi.org/10.1155/2012/403954 |
work_keys_str_mv |
AT koichitsuneyama pathologicalfeaturesofnewanimalmodelsforprimarybiliarycirrhosis AT yukimoritoki pathologicalfeaturesofnewanimalmodelsforprimarybiliarycirrhosis AT kentarokikuchi pathologicalfeaturesofnewanimalmodelsforprimarybiliarycirrhosis AT yasuninakanuma pathologicalfeaturesofnewanimalmodelsforprimarybiliarycirrhosis |
_version_ |
1725707409531338752 |