Development of a Self-Emulsifying Drug Delivery System for Optimized Topical Delivery of Clofazimine

Development of a Self-Emulsifying Drug Delivery System for Optimized Topical Delivery of Clofazimine

A quality-by-design and characterization approach was followed to ensure development of self-emulsifying drug delivery systems (SEDDSs) destined for topical delivery of the highly lipophilic clofazimine. Solubility and water-titration experiments identified spontaneous emulsification capacity of dif...

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Bibliographic Details
Main Authors: Daniélle van Staden, Jeanetta du Plessis, Joe Viljoen
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Pharmaceutics
Subjects:
topical delivery
self-emulsifying drug delivery system (SEDDS)
clofazimine
penetration enhancers
pseudo-ternary phase diagrams
Online Access:https://www.mdpi.com/1999-4923/12/6/523

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