Associations of per-/polyfluoroalkyl substances with glucocorticoids and progestogens in newborns
Background: Exposure to per-/polyfluoroalkyl substances (PFASs) can disrupt endocrine hormones in humans. Prior studies have focused on the harmful effects of the two traditional per-/polyfluoroalkyl substances (PFASs), perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA). Other PFASs,...
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Format: | Article |
Language: | English |
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Elsevier
2020-07-01
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Series: | Environment International |
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Online Access: | http://www.sciencedirect.com/science/article/pii/S0160412019328880 |
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doaj-81972f86b6b84b6b9bf4cb5068a56f9e |
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record_format |
Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hongxiu Liu Yitao Pan Shuna Jin Yuanyuan Li Liuqing Zhao Xiaojie Sun Qianqian Cui Bin Zhang Tongzhang Zheng Wei Xia Aifen Zhou Anna Maria Campana Jiayin Dai Shunqing Xu |
spellingShingle |
Hongxiu Liu Yitao Pan Shuna Jin Yuanyuan Li Liuqing Zhao Xiaojie Sun Qianqian Cui Bin Zhang Tongzhang Zheng Wei Xia Aifen Zhou Anna Maria Campana Jiayin Dai Shunqing Xu Associations of per-/polyfluoroalkyl substances with glucocorticoids and progestogens in newborns Environment International Per-/polyfluoroalkyl substances Glucocorticoids Progestogens Newborn |
author_facet |
Hongxiu Liu Yitao Pan Shuna Jin Yuanyuan Li Liuqing Zhao Xiaojie Sun Qianqian Cui Bin Zhang Tongzhang Zheng Wei Xia Aifen Zhou Anna Maria Campana Jiayin Dai Shunqing Xu |
author_sort |
Hongxiu Liu |
title |
Associations of per-/polyfluoroalkyl substances with glucocorticoids and progestogens in newborns |
title_short |
Associations of per-/polyfluoroalkyl substances with glucocorticoids and progestogens in newborns |
title_full |
Associations of per-/polyfluoroalkyl substances with glucocorticoids and progestogens in newborns |
title_fullStr |
Associations of per-/polyfluoroalkyl substances with glucocorticoids and progestogens in newborns |
title_full_unstemmed |
Associations of per-/polyfluoroalkyl substances with glucocorticoids and progestogens in newborns |
title_sort |
associations of per-/polyfluoroalkyl substances with glucocorticoids and progestogens in newborns |
publisher |
Elsevier |
series |
Environment International |
issn |
0160-4120 |
publishDate |
2020-07-01 |
description |
Background: Exposure to per-/polyfluoroalkyl substances (PFASs) can disrupt endocrine hormones in humans. Prior studies have focused on the harmful effects of the two traditional per-/polyfluoroalkyl substances (PFASs), perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA). Other PFASs, used as the replacements of PFOS and PFOA, are widely and increasingly detected in humans. Whether these replacements influence glucocorticoids and progestogens in newborns remains unknown. Objective: To investigate the associations between exposures of PFOS, PFOA and their replacements and glucocorticoids and progestogens in newborns. Methods: We measured the concentrations of 13 PFASs, 3 glucocorticoids (11-deoxycortisol, cortisol and cortisone) and 2 progestogens [progesterone, 17-hydroxyprogesterone (17OHP)] in the cord sera of 374 neonates in a birth cohort from Wuhan, China, between 2013 and 2014. We evaluated the associations of each PFAS with glucocorticoids and progestogens using multiple linear regression models, and multiple comparisons were additionally corrected via false discovery rates (FDR). Results: Out of the 13 PFASs, 9 were detected in over 95% of cord sera. The Chinese specific PFOS replacement − 6:2 chlorinated polyfluorinated ether sulfonate (6:2 Cl-PFESA, trade name F-53B) was positively associated with 13.13% change in cortisol in girls (95% CI = 4.47%, 22.52%, for each IQR increase in 6:2 Cl-PFESA). Seven PFASs had positive associations with the precursor of cortisol, namely 11-deoxycortisol (percent change ranged from 6.41% to 11.24%, for each IQR increase in PFASs). Perfluorobutane sulfonate (PFBS) in cord sera was positively associated with progesterone in the linear model, whereas PFOS and perfluorohexane sulfonate (PFHxS) levels were associated with progesterone in the quartile models. No PFASs were related to 17OHP or cortisone. Conclusions: In this study, PFOS, PFOA and/or their replacements were positively associated with progesterone, cortisol and 11-deoxycortisol in newborns. These results suggested that not only PFOS and PFOA, but also other PFASs have potential impacts on glucocorticoids and progestogens in newborns. |
topic |
Per-/polyfluoroalkyl substances Glucocorticoids Progestogens Newborn |
url |
http://www.sciencedirect.com/science/article/pii/S0160412019328880 |
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doaj-81972f86b6b84b6b9bf4cb5068a56f9e2020-11-25T02:49:28ZengElsevierEnvironment International0160-41202020-07-01140Associations of per-/polyfluoroalkyl substances with glucocorticoids and progestogens in newbornsHongxiu Liu0Yitao Pan1Shuna Jin2Yuanyuan Li3Liuqing Zhao4Xiaojie Sun5Qianqian Cui6Bin Zhang7Tongzhang Zheng8Wei Xia9Aifen Zhou10Anna Maria Campana11Jiayin Dai12Shunqing Xu13Key Laboratory of Environment and Health (HUST), Ministry of Education & Ministry of Environmental Protection, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, Hubei, PR China; State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, Hubei, PR ChinaKey Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, PR ChinaKey Laboratory of Environment and Health (HUST), Ministry of Education & Ministry of Environmental Protection, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, Hubei, PR China; State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, Hubei, PR ChinaKey Laboratory of Environment and Health (HUST), Ministry of Education & Ministry of Environmental Protection, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, Hubei, PR China; State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, Hubei, PR ChinaKey Laboratory of Environment and Health (HUST), Ministry of Education & Ministry of Environmental Protection, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, Hubei, PR China; State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, Hubei, PR ChinaKey Laboratory of Environment and Health (HUST), Ministry of Education & Ministry of Environmental Protection, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, Hubei, PR China; State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, Hubei, PR ChinaKey Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, PR ChinaWomen and Children Medical and Healthcare Center of Wuhan, Wuhan 430000, Hubei, PR ChinaDepartment of Epidemiology, School of Public Health, Brown University, Providence, RI 02912, United StatesKey Laboratory of Environment and Health (HUST), Ministry of Education & Ministry of Environmental Protection, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, Hubei, PR China; State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, Hubei, PR ChinaWomen and Children Medical and Healthcare Center of Wuhan, Wuhan 430000, Hubei, PR ChinaNew York University, New York 10016, United StatesKey Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, PR China; Corresponding authors at: No. 13 HangKong Road, Wuhan, Hubei, PR China (S. Xu). No. 1, Beichen West Road, Chaoyang District, Beijing, PR China (J. Dai).Key Laboratory of Environment and Health (HUST), Ministry of Education & Ministry of Environmental Protection, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, Hubei, PR China; State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, Hubei, PR China; Corresponding authors at: No. 13 HangKong Road, Wuhan, Hubei, PR China (S. Xu). No. 1, Beichen West Road, Chaoyang District, Beijing, PR China (J. Dai).Background: Exposure to per-/polyfluoroalkyl substances (PFASs) can disrupt endocrine hormones in humans. Prior studies have focused on the harmful effects of the two traditional per-/polyfluoroalkyl substances (PFASs), perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA). Other PFASs, used as the replacements of PFOS and PFOA, are widely and increasingly detected in humans. Whether these replacements influence glucocorticoids and progestogens in newborns remains unknown. Objective: To investigate the associations between exposures of PFOS, PFOA and their replacements and glucocorticoids and progestogens in newborns. Methods: We measured the concentrations of 13 PFASs, 3 glucocorticoids (11-deoxycortisol, cortisol and cortisone) and 2 progestogens [progesterone, 17-hydroxyprogesterone (17OHP)] in the cord sera of 374 neonates in a birth cohort from Wuhan, China, between 2013 and 2014. We evaluated the associations of each PFAS with glucocorticoids and progestogens using multiple linear regression models, and multiple comparisons were additionally corrected via false discovery rates (FDR). Results: Out of the 13 PFASs, 9 were detected in over 95% of cord sera. The Chinese specific PFOS replacement − 6:2 chlorinated polyfluorinated ether sulfonate (6:2 Cl-PFESA, trade name F-53B) was positively associated with 13.13% change in cortisol in girls (95% CI = 4.47%, 22.52%, for each IQR increase in 6:2 Cl-PFESA). Seven PFASs had positive associations with the precursor of cortisol, namely 11-deoxycortisol (percent change ranged from 6.41% to 11.24%, for each IQR increase in PFASs). Perfluorobutane sulfonate (PFBS) in cord sera was positively associated with progesterone in the linear model, whereas PFOS and perfluorohexane sulfonate (PFHxS) levels were associated with progesterone in the quartile models. No PFASs were related to 17OHP or cortisone. Conclusions: In this study, PFOS, PFOA and/or their replacements were positively associated with progesterone, cortisol and 11-deoxycortisol in newborns. These results suggested that not only PFOS and PFOA, but also other PFASs have potential impacts on glucocorticoids and progestogens in newborns.http://www.sciencedirect.com/science/article/pii/S0160412019328880Per-/polyfluoroalkyl substancesGlucocorticoidsProgestogensNewborn |