Renin Promotes STAT4 Phosphorylation to Induce IL-17 Production in Keratinocytes of Oral Lichen Planus
Summary: Interleukin-17 (IL-17) is highly expressed in the epithelial layer of oral lichen planus (OLP), but the underlying mechanism for IL-17 overexpression remains unknown. Here, we identify renin that is induced by NF-κB pathway contributes to the increase of IL-17 in human oral keratinocytes (H...
Main Authors: | Xuejun Ge, Hanting Xie, Tivoli Nguyen, Bin Zhao, Jing Xu, Jie Du |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2020-04-01
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Series: | iScience |
Online Access: | http://www.sciencedirect.com/science/article/pii/S258900422030167X |
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