Fetuin-A deficiency protects mice from Experimental Autoimmune Encephalomyelitis (EAE) and correlates with altered innate immune response.

Fetuin-A deficiency protects mice from Experimental Autoimmune Encephalomyelitis (EAE) and correlates with altered innate immune response.

Fetuin-A is a biomarker of disease activity in multiple sclerosis. Our aim was to investigate whether Fetuin-A plays a direct role in the neuroinflammatory response in the mouse EAE model. Peak Fetuin-A expression in the CNS and in peripheral lymphoid tissue correlated with peak EAE disease activity...

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Main Authors: Violaine K Harris, Lena Bell, Ruth-Anne Langan, John Tuddenham, Mark Landy, Saud A Sadiq
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5384772?pdf=render
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spelling doaj-81a6f98d833c40d3903f8254c1edd9012020-11-25T01:35:58ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01124e017557510.1371/journal.pone.0175575Fetuin-A deficiency protects mice from Experimental Autoimmune Encephalomyelitis (EAE) and correlates with altered innate immune response.Violaine K HarrisLena BellRuth-Anne LanganJohn TuddenhamMark LandySaud A SadiqFetuin-A is a biomarker of disease activity in multiple sclerosis. Our aim was to investigate whether Fetuin-A plays a direct role in the neuroinflammatory response in the mouse EAE model. Peak Fetuin-A expression in the CNS and in peripheral lymphoid tissue correlated with peak EAE disease activity. Fetuin-A-deficient mice showed reduced EAE severity associated with an accumulation of splenic monocyte and dendritic cell populations, increased IL-12p40, ASC1, and IL-1β expression, and an increase in T regulatory cells. The upregulation of Fetuin-A in LPS-stimulated dendritic cells and microglia further supports an intrinsic role of Fetuin-A in regulating innate immune activation during EAE.http://europepmc.org/articles/PMC5384772?pdf=render
collection DOAJ
language English
format Article
sources DOAJ
author Violaine K Harris
Lena Bell
Ruth-Anne Langan
John Tuddenham
Mark Landy
Saud A Sadiq
spellingShingle Violaine K Harris
Lena Bell
Ruth-Anne Langan
John Tuddenham
Mark Landy
Saud A Sadiq
Fetuin-A deficiency protects mice from Experimental Autoimmune Encephalomyelitis (EAE) and correlates with altered innate immune response.
PLoS ONE
author_facet Violaine K Harris
Lena Bell
Ruth-Anne Langan
John Tuddenham
Mark Landy
Saud A Sadiq
author_sort Violaine K Harris
title Fetuin-A deficiency protects mice from Experimental Autoimmune Encephalomyelitis (EAE) and correlates with altered innate immune response.
title_short Fetuin-A deficiency protects mice from Experimental Autoimmune Encephalomyelitis (EAE) and correlates with altered innate immune response.
title_full Fetuin-A deficiency protects mice from Experimental Autoimmune Encephalomyelitis (EAE) and correlates with altered innate immune response.
title_fullStr Fetuin-A deficiency protects mice from Experimental Autoimmune Encephalomyelitis (EAE) and correlates with altered innate immune response.
title_full_unstemmed Fetuin-A deficiency protects mice from Experimental Autoimmune Encephalomyelitis (EAE) and correlates with altered innate immune response.
title_sort fetuin-a deficiency protects mice from experimental autoimmune encephalomyelitis (eae) and correlates with altered innate immune response.
publisher Public Library of Science (PLoS)
series PLoS ONE
issn 1932-6203
publishDate 2017-01-01
description Fetuin-A is a biomarker of disease activity in multiple sclerosis. Our aim was to investigate whether Fetuin-A plays a direct role in the neuroinflammatory response in the mouse EAE model. Peak Fetuin-A expression in the CNS and in peripheral lymphoid tissue correlated with peak EAE disease activity. Fetuin-A-deficient mice showed reduced EAE severity associated with an accumulation of splenic monocyte and dendritic cell populations, increased IL-12p40, ASC1, and IL-1β expression, and an increase in T regulatory cells. The upregulation of Fetuin-A in LPS-stimulated dendritic cells and microglia further supports an intrinsic role of Fetuin-A in regulating innate immune activation during EAE.
url http://europepmc.org/articles/PMC5384772?pdf=render
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AT lenabell fetuinadeficiencyprotectsmicefromexperimentalautoimmuneencephalomyelitiseaeandcorrelateswithalteredinnateimmuneresponse
AT ruthannelangan fetuinadeficiencyprotectsmicefromexperimentalautoimmuneencephalomyelitiseaeandcorrelateswithalteredinnateimmuneresponse
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AT marklandy fetuinadeficiencyprotectsmicefromexperimentalautoimmuneencephalomyelitiseaeandcorrelateswithalteredinnateimmuneresponse
AT saudasadiq fetuinadeficiencyprotectsmicefromexperimentalautoimmuneencephalomyelitiseaeandcorrelateswithalteredinnateimmuneresponse
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