Analysis of the concordance between the estimated values of creatinine clearance using the Cockcroft-Gault equation and the real value determined in patients from the Hospital Clínica Bíblica
Objective: to analyze the effect of the modifications in the Cockcroft-Gault equation for creatinine clearance rate determination (CrCl) and its concordance with the real value determined from 24-hours urine collection in a sample of Latin American patients hospitalized in San José de Costa Rica. Me...
Main Authors: | , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Grupo Aula Médica
2016-01-01
|
Series: | Farmacia Hospitalaria |
Subjects: | |
Online Access: | http://www.aulamedica.es/fh/pdf/8859.pdf |
id |
doaj-81bdeb282fbf4304ba114f4bdc5a7def |
---|---|
record_format |
Article |
spelling |
doaj-81bdeb282fbf4304ba114f4bdc5a7def2020-11-25T01:30:53ZengGrupo Aula MédicaFarmacia Hospitalaria1130-63432171-86952016-01-0140131310.7399/fh.2016.40.1.8859Analysis of the concordance between the estimated values of creatinine clearance using the Cockcroft-Gault equation and the real value determined in patients from the Hospital Clínica BíblicaJose Miguel Chaverri-Fernández0Esteban Zavaleta-Monestel1Jose Pablo Díaz-Madriz2Angie Ortiz-Ureña3Monica Ramírez-Hernández4Karina Trejos- Morales5Department of Pharmacology, Toxicology, and Drug Dependence of the School of Pharmacy, Universidad de Costa Rica. Clinical Pharmacist, Hospital Clínica Bíblica, San José.Head of Pharmacy at the Hospital Clínica Bíblica, San JoséClinical Pharmacist. Hospital Clínica Bíblica, San José.Department of Pharmacology, Toxicology and Drug Dependence of the School of Pharmacy, Universidad de Costa RicaIntern Students. University of Medical Sciences UCIMED-Hospital Clínica Bíblica. Costa RicaIntern Students. University of Medical Sciences UCIMED-Hospital Clínica Bíblica. Costa RicaObjective: to analyze the effect of the modifications in the Cockcroft-Gault equation for creatinine clearance rate determination (CrCl) and its concordance with the real value determined from 24-hours urine collection in a sample of Latin American patients hospitalized in San José de Costa Rica. Method: an observational, retrospective study, with patients submitted to a 24-hour urine collection test, and who met the inclusion criteria. The real and estimated values of creatinine clearance were determined, and their concordance was measured by applying the Intraclass Correlation Coefficient; a descriptive analysis of data was also conducted. Results: there were 507 subjects (61% men); their age was described (ME = 60 years SD = 17 years), as well as their height (ME = 1.66 m SD = 0.09 m), current weight (ME =75 kg SD = 15 kg), body mass index (ME = 27.3 kg/m2 SD = 4.76 kg/m2) and endogenous creatinine clearance rates (ME = 69.72 ml/min SD = 33 ml/min). The best concordance with the equation was obtained with current weight values and serum creatinine without rounding. Conclusions: the application of the Cockcroft-Gault equation that matches more closely the real value is the one that uses current weight and does not round creatinine values below 1 mg/dL. It is suggested to conduct a prospective analysis, determining other variables that could affect CrCl real measures, and to replicate this methodology in specific populations. *ME: Mean **SD: Standard Deviation http://www.aulamedica.es/fh/pdf/8859.pdfRenal clearanceCreatinineClinical Pharmacy UnitPharmacokinetics |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jose Miguel Chaverri-Fernández Esteban Zavaleta-Monestel Jose Pablo Díaz-Madriz Angie Ortiz-Ureña Monica Ramírez-Hernández Karina Trejos- Morales |
spellingShingle |
Jose Miguel Chaverri-Fernández Esteban Zavaleta-Monestel Jose Pablo Díaz-Madriz Angie Ortiz-Ureña Monica Ramírez-Hernández Karina Trejos- Morales Analysis of the concordance between the estimated values of creatinine clearance using the Cockcroft-Gault equation and the real value determined in patients from the Hospital Clínica Bíblica Farmacia Hospitalaria Renal clearance Creatinine Clinical Pharmacy Unit Pharmacokinetics |
author_facet |
Jose Miguel Chaverri-Fernández Esteban Zavaleta-Monestel Jose Pablo Díaz-Madriz Angie Ortiz-Ureña Monica Ramírez-Hernández Karina Trejos- Morales |
author_sort |
Jose Miguel Chaverri-Fernández |
title |
Analysis of the concordance between the estimated values of creatinine clearance using the Cockcroft-Gault equation and the real value determined in patients from the Hospital Clínica Bíblica |
title_short |
Analysis of the concordance between the estimated values of creatinine clearance using the Cockcroft-Gault equation and the real value determined in patients from the Hospital Clínica Bíblica |
title_full |
Analysis of the concordance between the estimated values of creatinine clearance using the Cockcroft-Gault equation and the real value determined in patients from the Hospital Clínica Bíblica |
title_fullStr |
Analysis of the concordance between the estimated values of creatinine clearance using the Cockcroft-Gault equation and the real value determined in patients from the Hospital Clínica Bíblica |
title_full_unstemmed |
Analysis of the concordance between the estimated values of creatinine clearance using the Cockcroft-Gault equation and the real value determined in patients from the Hospital Clínica Bíblica |
title_sort |
analysis of the concordance between the estimated values of creatinine clearance using the cockcroft-gault equation and the real value determined in patients from the hospital clínica bíblica |
publisher |
Grupo Aula Médica |
series |
Farmacia Hospitalaria |
issn |
1130-6343 2171-8695 |
publishDate |
2016-01-01 |
description |
Objective: to analyze the effect of the modifications in the Cockcroft-Gault equation for creatinine clearance rate determination (CrCl) and its concordance with the real value determined from 24-hours urine collection in a sample of Latin American patients hospitalized in San José de Costa Rica. Method: an observational, retrospective study, with patients submitted to a 24-hour urine collection test, and who met the inclusion criteria. The real and estimated values of creatinine clearance were determined, and their concordance was measured by applying the Intraclass Correlation Coefficient; a descriptive analysis of data was also conducted. Results: there were 507 subjects (61% men); their age was described (ME = 60 years SD = 17 years), as well as their height (ME = 1.66 m SD = 0.09 m), current weight (ME =75 kg SD = 15 kg), body mass index (ME = 27.3 kg/m2 SD = 4.76 kg/m2) and endogenous creatinine clearance rates (ME = 69.72 ml/min SD = 33 ml/min). The best concordance with the equation was obtained with current weight values and serum creatinine without rounding. Conclusions: the
application of the Cockcroft-Gault equation that matches more closely the real value is the one that uses current weight and does not round creatinine values below 1 mg/dL. It is suggested to conduct a prospective analysis, determining other variables that could affect CrCl real measures, and to replicate this methodology in specific populations. *ME: Mean **SD: Standard Deviation
|
topic |
Renal clearance Creatinine Clinical Pharmacy Unit Pharmacokinetics |
url |
http://www.aulamedica.es/fh/pdf/8859.pdf |
work_keys_str_mv |
AT josemiguelchaverrifernandez analysisoftheconcordancebetweentheestimatedvaluesofcreatinineclearanceusingthecockcroftgaultequationandtherealvaluedeterminedinpatientsfromthehospitalclinicabiblica AT estebanzavaletamonestel analysisoftheconcordancebetweentheestimatedvaluesofcreatinineclearanceusingthecockcroftgaultequationandtherealvaluedeterminedinpatientsfromthehospitalclinicabiblica AT josepablodiazmadriz analysisoftheconcordancebetweentheestimatedvaluesofcreatinineclearanceusingthecockcroftgaultequationandtherealvaluedeterminedinpatientsfromthehospitalclinicabiblica AT angieortizurena analysisoftheconcordancebetweentheestimatedvaluesofcreatinineclearanceusingthecockcroftgaultequationandtherealvaluedeterminedinpatientsfromthehospitalclinicabiblica AT monicaramirezhernandez analysisoftheconcordancebetweentheestimatedvaluesofcreatinineclearanceusingthecockcroftgaultequationandtherealvaluedeterminedinpatientsfromthehospitalclinicabiblica AT karinatrejosmorales analysisoftheconcordancebetweentheestimatedvaluesofcreatinineclearanceusingthecockcroftgaultequationandtherealvaluedeterminedinpatientsfromthehospitalclinicabiblica |
_version_ |
1725089200862134272 |